HIV gp 120 - CD4 (T-Helper) EBV gp350/220 - CD21 (B cells) Rhinoviruses VP1,3 - ICAM-1 (epithelium) Herpes - Takes the

inner Neucleur membrane not like usual plasma m FEVER + RASH same time = Parvo (B-19) slapped cheek (ss dna) CROSS PLACENTA Koilocytes = Papovirdae (circular ds dna) - BK/JC HPV [Condylomata acuminata (ge nital warts)] HPV = cervical cancer (E6 binds to p53, E7 binds to Rb) Laryngeal papillomas (HPV-6 and HPV-11) & HPV-16 and HPV-18 (associated with cer vical cancer) BK = glomerulonuphritis & JC = Progressive multifocal leukoencephalopathy *immun ocompr pts* Swimming pools and pink eye = Adenovirus (Acute Resp. Tract Infection) (40, 41 c auses Diarrhea) Gym, Orf, Monkey PoX = Poxovirdae = Small Pox (largest virus replicates in the c ytoplasm (ds DNA)) Orf = Pox virus of sheep and goats and Monkeypox = Prairie dogs *Molluscum Contagiosum* = wrestling Hepatitis B = Hepadnaviridae (partially DS) used a reverse transcriptase and RNA intermediate during replication - Type III hypersensitivity HERPES!!!! HSV-1: trigeminal ganglia --> Temporal Brain Virus replicates at site of initial infection Gingivostomatitis = Recurrent Stomatitis (cold sores, fever blisters) = Recurrent oral herpe s labialis Ocular Herpes Herpes Gladiatorum HSV-2: sacral ganglia Virus replicates at site of initial infection Herpetic Whitlow = HURTS Encephaltitis = HSV2- neonatal (NO localization) Post neonatal = HSV1 Te mporal BONE VZV: dorsal root ganglia Respiratory tract, Virus is shed from vesicular lesion Maculopapular to vesicular, to crusting scabs B cells: EBV = Primary target cell for EBV is the epithelial cell within the oro pharynx (Parotid G) Infectious mononucleosis (IM) = Enlarged Lymph NODES (you can see them m assive) Spleen does the same thing *bilateral lymphadenopathy* Atypical lymphoc ytes in BLOOD If you give patients with IM ampicillin 100% will develop rash (IMPORTAN T) ***heterophil-positive*** Burkitt s lymphoma (BL) = Africa and co-carcinogen is malaria Nasopharyngeal carcinoma = CHINA

Lymphoproliferative Disease = Usually occur in people with T cell immuno deficiency Hodgkin s Lymphoma White blood cells: CMV and HHV-6 CytoMegaloVirus = Primary infections of pregnant women place the fetus a t greatest risk ****100% of renal allograph patients convert to CMV seropositive and wit h late stage AIDs secrete CMV from multiple sites*** ***heterophil-negative*** + = mo no CMV infections represent the leading cause of mental retardation due to congenital infection HHV-6 --> Fever then RASH (Rash and Fever @ the same time = B19, slap) HHV-8 --> Kaposi s sarcoma cjd /ffi = Must have aspartic acid to asparagine mutation at codon 178 Second mutation at codon 129 determines disease If valine then familial (inheri ted) CJD If methionine then FFI Babesia microti = maltease cross/ ring stage and is transfered by black legged T ICK Enterobius vermicularis = Pinworm - Oral/Fecal autoinfection occurs Trichuris trichiura = Whip worm (football shaped with plugs @ end) bloody diarrh ea Paragonimus westermani = LUNG fluke (snail intermediate host) and (infection fro m raw crab/crayfish) Flat, leaf-shaped with opperculated eggs Aminoglycoside = Blocks binding of fmet-tRNA to ribosome Tetracycline Resistance = Action blocks binding of aminoacyl tRNAs (EFFLUX) Chloramphenicol = Action binds to 50S subunit, inhibits peptide bond formation Rifampin = Action binds to RNA polymerase, stops transcription Quinolones = inhibition of DNA gyrase, unable to pack DNA into cell Antifolates = interfere with bacterial synthesis of folic acid Sulfonamides = Competes with PABA as substrate Trimethoprim = Competitive inhibitor of dihydrofolate reductase Actinomyces = Sulfur Granules - Lymph messed up and puffy oral "Lumpy Jaw" B. fragilis = GI abscesses / Foul or putrid smelling odor Clostridium tetani - Tetani ***Trismus and Hydrophobia*** Looks like a "drumstick" - Prevents release of inhibitory transmitters " Lock Jaw" = Trismus Clostridium botulinum - Botulism With home canning, infant with honey "Floppy baby syndrome" - blocks rel ease of acetylcholine Clostridium difficile - Pseudomembranous colitis Antibiotic-associated GI diseases *Green Diarrhea* Clostridium perfringens - *BRONZE COLORED blisters* Amputees must consider! A = Gas gangrene, food poisoning (alpha toxin causes Gan Gangrene) C = Necrotizing enteritis Chlamydia trachomatis

Trachoma (A, B, Ba and C) Blindness, first exposure results in acute conjunctivitis which usually resolves then chronic leads to B Inclusion conjunctivitis (D-K) Not associated with permanent eye damage or chronicity Non-Gonococcal urethritis (D-K) STD. most common in US Lymphogranuloma venerum (LGV) (L1, L2, L2a, and L3) Extensive ulceration and blockage or regional lymph drainage ****MYCOPLASMA PNEMONIA!!!!!!!!!!***** NO FRIED EGG APPEREANCE, BUT THE OTHER O NES DO HAVE A FRIED EGG APPEREANCE Teen presents with nonpurulent otitis media and lower resp infection. Cold agglu tinins test is positive shift far away drift close