Mary Ann Timmerman, MS, MSBS Home: 855B Sandlake Drive ~ Mount Pleasant, SC 29464 Work: CVAMC ~ 109

Bee Street (116) ~ Charleston, SC 29401 Home (843) 216-0422 ~ Work (843) 789-7502 ~ mtb1d214@westpost.net QUALIFICATIONS PROFILE Clinical Trial Management ~ Biomedical Science ~ Epidemiology ~ Grant Writing & Administration Highly astute, versatile, and diligent professional offering a flexible and adap table background in clinical trial management, project coordination, statistical analysis, and grant writing/administration among all disease processes. Extensi ve educational training in studying Oncology, CVD, Diabetes, TBI, Hypertension, etc through a multitude of real-life clinical trial vignettes. Strong experience at the Medical University of South Carolina (MUSC), including successfully secu ring an independent NIH-NIAAA F31 grant. Concurrently manages all aspects of fou r pharmacological clinical trials. Praised for insight and capabilities in imple menting research protocols. Recipient of the prestigious MUSC Presidential Schol ar Award. Team-oriented work ethic with excellent multitasking and organizationa l abilities combined with strong interpersonal and communication skills. Availab le for travel and relocation. Additional expertise includes: *Pharmacological Clinical Trials *Statistical Analysis *Database design & Management *edc systems & genetics * Research Grants & Proposals *Subject Recruitment & Retention *Project Development & Management *Regulatory affairs & compliance EDUCATION Medical University of South Carolina, Charleston, SC Master of Science, BIOMEDICAL SCIENCE, Focus in Epidemiology/Research Administra tion, 12/2009 Virginia Polytechnic Institute & State University, Blacksburg, VA Master of Science, EXPERIMENTAL PSYCHOLOGY, Focus in Substance Abuse Research, 5 /1999 Lander University, Greenwood, SC Bachelor of Science - PSYCHOLOGY, Focus in Psychological Research, Magna cum Lau de, 5/1997 Piedmont Technical College, Greenwood, SC Associate of Science, HUMAN SERVICES, 12/1994 Associate of Science, BUSINESS AND SOCIAL MARKETING, 5/1985 AWARDS & GRANTS NIH-NIAAA F31 Grant, 2005 - 2007 Presidential Scholar, Medical University of South Carolina, 2005 Grantee, Anheuser-Busch Corporation, 1998-1999 Psi Chi Research Award, 1997 Outstanding Research Student Award, Lander University, Behavioral Science Divisi on, 1997 1st Place, South Carolina Psychological Association Psychology Bowl, 1996

PROFESSIONAL EXPERIENCE Charleston Research Institute/CVAMC/MUSC, Charleston, SC (2007 - Present) SENIOR CLINICAL TRIAL MANAGER Oversee numerous federal, VA Merit, and industry-sponsored pharmacological trial s, including regulatory and budget management. Hire and supervise research assis tants/coordinators. Devise recruitment and retention strategies, ensure protecti on of human subjects, formulate assessments and study procedures, and serve as a liaison to multiple sites. Manage databases, perform statistical analysis, and coordinate EDC systems. Prepare and submit grant submissions, adverse events rep orting, and manuscript preparation for PIs. Analyze and adhere to risk and compl iance issues. Key Achievements: Pursuing CRA designation, a national accreditation in research administration and assisting PI with completion of a genetics study. Department of Psychiatry and Behavioral Science, MUSC, Charleston, SC (2002 - 20 05) PROJECT COORDINATOR II Implemented NIH-funded and industry research studies on PTSD, substance abuse, a nd other comorbidities. Delivered key contributions as a grant writing assistant and primary statistical analyst for Kathleen T. Brady, MD, PhD on numerous stud ies. Subject assessments conducted and protocols implemented. Close relationship with the General Clinical Research Center on campus. Department of Psychiatry and Behavioral Science, MUSC, Charleston, SC (2000 - 20 02) STATISTICAL RESEARCH ANALYST III Spearheaded database design and management.Primary research coordinator on sever al studies. Served as a statistical analyst. Orchestrated project management as well as TELEFORM design and management. Center for Drug and Alcohol Programs, MUSC, Charleston, SC (1999 - 2000) MENTAL HEALTH COORDINATOR Conceptualized, developed, and executed an inpatient reward-based substance abus e program which was highly exalted by key physicians. Delivered substance abuse/ psychological counseling, including functioning as a group facilitator or indepe ndent counselor. ADDITIONAL EXPERIENCE Department of Medicine, Division of Biomedical Science, MUSC, Charleston, SC NIH/NIAAA F31 GRANT RECIPIENT, 2005-2007 Principle Investigator: "Social Capital and Alcohol-related mortalities, ER admi ssions, and treatment utilization among the counties of South Carolina" Drove research grant from NIH submission to closure which resulted in the develo pment of one of the most extensive alcohol-related databases in the state. Resul ted in three manuscripts for journal submission. Center for Applied Behavior Systems, Virginia Polytechnic Institute & State Univ ersity, Blacksburg, VA GRADUATE RESEARCH ASSISTANT, 1998-1999 Project Director Garnered an Anheuser-Busch grant to develop an alcohol intervention/prevention p rogram featuring a city-wide designated driver program for college students. Utilized SPSS, performed SAS data analysis, and coordinated large-scale database s (Access, Excel, etc.).

Supervised over 20 research assistants. Authored and published a master's thesis detailing findings. Taught a sophomore-level Research Methodology course. Department of Psychology, Virginia Polytechnic Institute & State University, Bla cksburg, VA Graduate Research Assistant, 8/1997-12/1997, Visual Perception Study Secondary Investigator working under Principal Investigator: Dr. Albert Prestrud e / Specialty: Sensory Perception. Contributed to a study on the aesthetic aspe cts of particular streams in eastern Tennessee under funding from Champion Paper .Organized field research, performed data analysis, and managed database. TECHNICAL SKILLS MS OFFICE [MS Word, Excel, Access, Outlook, Publisher] Word Perfect EDC PROGRAMS, INFORM, CLARIX, IVRS/IWR, SAS, SPSS, STATA, RedCAP, EGRIT, R, S-PL US, N-QUERY, DSMB COPY, MINITAB, TELEFORM AFFILIATIONS & INVOLVEMENT * * * * * * * American Statistical Association, 2002-Present Society for Epidemiological Research, 2003-Present Research Society on Alcoholism, 2003-Present Psi Chi National Honor Society for Psychology, 1995 -1997 Alpha Chi National Honor Society, 1996-1997 Lander University Psychology Club, 1996-1997 Psi Beta National Honor Society for Psychology, 1993-1995

COMMUNITY ACTIVITIES Volunteer, Sanders Clyde Elementary Lunch Buddy Program, 2004-2007 President, Lander University Psychology Club, 1996-1997 Vice President, Psi Beta National Honor Society for Psychology, 1993-1995 Volunteer, Hospice Day Camp for Children, Greenwood, SC, 1996-1997 Volunteer, Leathe Correctional Facility for Women, Greenwood, SC, 1993-1997 Group Facilitator, School Intervention Program, Calhoun Falls High School, 19941997 Board Member, Greenwood County Mental Health Association, 1994-1997 SELECTED PUBLICATIONS & PRESENTATIONS * Verduin M.L., Carter, R.E., Brady, K.T., Myrick, H., & Timmerman, M.A., (2005) . Health service utilization in comorbid bipolar and substance abuse disorders: a retrospective chart review. Psychiatric Services Apr; 56(4):475-80. * McRae, AL, Brady KT, Mellman TA, Sonne SC, Killeen TK, Timmerman MA, & BaylesDazet W. (2004). Comparison of nefazodone and sertraline for the treatment of po sttraumatic stress disorder. Depression and Anxiety, 19(3): 190-6. * Upadhyaya HP, Santa Ana E, Saladin ME, Spratt EG, Timmerman MA, Brady KT, McRa e AL, & Waldrop A. (2004). Trauma-specific factors and stress responding in como rbid PTSD and substance use disorder. Poster presentation: American Academy of C hild and Adolescent Psychiatry: Washington, DC. * Santa Ana, E.L., Saladin, M., Spratt, E., Brady, K.T., & Timmerman, M.A., (200 4). Physiological responses to stress in comorbid PTSD & alcohol-dependence. Pap er presentation: College of Problems in Drug Dependence: San Juan, Puerto Rico. * Timmerman, M.A., Geller, E.S., Glindemann, K.E., Fortnier, A. (2003). Do the d esignated drivers of college students stay sober? Journal of Safety Research 34( 2):127-33. [Master's Thesis Published] * Back, S.E., McRae, A.L., Brady, K.T., Anton, R.F., Randall, C. & Timmerman, M. A. (2002). Relationship between stress reactivity and subsequent alcohol use. Po

ster session: College on Problems of Drug Dependence. * Timmerman, M.A., Glindemann, K., Carter, N., & Geller, E.S. (1999). An evaluat ion of designated driver use: Does it lead to increased levels of passenger into xication? Paper presented at the Association of Applied Behavior Analysis Confer ence [May 1999]. Chicago, IL. * Timmerman, M.A., Grossman, B.M., Lea, B.N., & Booth, S. (1999). A field study of factors influencing the use of designated drivers in a community setting. Po ster presented at the Association of Applied Behavior Analysis Conference [May 1 999]. Chicago, IL. * Glindemann, K.E., Timmerman, M.A., & Clarke, S.W. (1998). Effects of peer inf luence and history of alcohol consumption on perceptions of normative alcohol us e. Published in Advances and Challenges in Prevention Science for the 21st Cent ury: Proceedings of the 6th Annual Meeting of the Society for Prevention Researc h. * Timmerman, M.A., (1997). Academic achievement, locus of control, & the imposto r phenomenon. Senior Honors Thesis, May 1997. RECENT GRANT EXPERIENCE Lead Research Coordinator VA/DOD (Investigator Initiated) A Randomized, Placebo-Controlled Trial of the Dopamine-*-Hydroxylase Inhibitor, Nepicastat, for the Treatment of PTSD in OIF/OEF Veterans. Goals: Proposed a multi-site, randomized, double-blind, placebo-controlled pilo t clinical trial of the dopamine-* -hydroxylase (DBH) inhibitor, nepicastat, for the treatment of PTSD in outpatients who have previously served in a combat zon e during Operation Iraqi Freedom & Operation Enduring Freedom. Repligen Corporation RG2417-03 A Phase II Randomized, Double-Blind, Placebo-Controlled, Flexible-Dose Study to Assess the Safety, Tolerability and Efficacy of RG2417 (Uridine) in the Treatmen t of Bipolar I Depression. Otsuka Pharmaceuticals I. A 38-week, Multicenter, Randomized, Double-blind, Active-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of an Intramuscular Depot Formul ation of Aripiprazole (OPC-14597) as Maintenance Treatment in Patients with Schi zophrenia. II. A 52-week, Multicenter, Open-label Study to Evaluate the Effectiveness of Ar ipiprazole Intramuscular Depot as Maintenance Treatment in Patients with Schizop hrenia. Statistical Analyst U.S. Department of Veterans Affairs, ORD, Clinical Science Service Clinical Research Merit A Placebo-Controlled Trial of Adjunctive Quetiapine for Refractory PTSD. Goals: Focused on improving prior methodologies by enrolling patients deemed re fractory to paroxetine after an initial 8-week prospective open-label trial. Ob jective is to evaluate the efficacy of this combination strategy on core PTSD sy mptoms, associated symptoms and comorbidities, sleep disturbances, cognitive fun ctioning, quality of life, and overall level of functioning. Sub-Investigator Pfizer Pharmaceuticals Ziprasidone Augmentation for Treatment-Resistant PTSD in Veterans of the Iraq-Ir

an Wars. Goals: A two-phase study which prospectively identified veterans' refractory to 8 weeks of treatment with an antidepressant which is FDA-approved for the treatm ent of DSM-IV PTSD in addition to augmenting treatment with ziprasidone or place bo for an additional 8 weeks. VETERANS AFFAIRS OFFICE OF RESEARCH & DEVELOPMENT MVP: Million Veteran Program Goals: To better understand how genetics affect health and illness in order to i mprove healthcare for Veterans. PROFESSIONAL REFERENCES KATHLEEN T. BRADY, MD, PHD - Distinguished Professor of Psychiatry; Director, Cl inical Neuroscience Division. Associate Dean for Clinical Research; Director, G eneral Clinical Research Center at MUSC. Contact Information: 843-792-5215: bradyk@musc.edu KATHRYNM.MAGRUDER, MPH, PHD -Chair of Institutional Review Board I; Professor, D epartment of Psychiatry & Behavioral Sciences, Military ScienceDivision. Departm ent of Medicine, Division of Biostatistics & Epidemiology, MUSC. Contact Information: 843.789.7280: magrudkm@musc.edu. Robert S. Woolson, PhD -Professor Emeritus of Biostatistics and Epidemiology, De partment of Medicine, MUSC. Contact Information: 843-876-1135: woolson@musc.edu. Adjunct Professor of Bios tatistics & Bioinformatics and Senior Statistical Consultant for Center for Heal th Services Research and Development for Primary Care, Duke University - skip.wo olson@duke.edu