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WORLD WATCH •

Working for a Sustainable Future

A New Racism
by Nadine Gordimer

Deceptive Promises of Cures for Disease


by Sarah Sexton

The New Eugenics


by Michael Dorsey

Views from Around the World


Biopirates and the Poor
by Vandana Shiva

What Human Genetic Modification Means for Women


by Judith Levine

In Defense of Nature, Human and Non-Human


by Francis Fukuyama

The Human Rights Perspective


by Rosario Isasi

The Genome as a Commons


Tom Athanasiou and Marcy Darnovsky

The War of Words and Images


by Brian Halweil

Why Environmentalists Should Be Concerned


by Bill McKibben

Human Engineering Timeline

Excerpted from July/August 2002 WORLD WATCH magazine


© 2002 Worldwatch Institute

For more information about Worldwatch


Institute and its programs and publications, please
visit our website at www.worldwatch.org
WI O R L D WAT C H
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Nadine Gordimer
A New
Racism
Just when we thought apartheid had been banished for good.

L ast spring World Watch interviewed South African


writer Nadine Gordimer on her concerns about
human genetic engineering.

World Watch: Last year, in Durban, you gave a speech


stant wish to discover. If you’re a writer, you are always
looking for the meaning of human life; your whole
writing life is a process of discovery, of solving the
mystery of human nature. So I can see that if you are
a scientist you have this urge to discover. But unfor-
at the U.N. conference on racism, and you suggested tunately, when you are brilliant and lucky enough to
that human engineering could be the new face of strike on something, it may be a Pandora’s box that
racism. Could you elaborate? you have opened, not the key to the world’s wisdom.
Nadine Gordimer: There are precedents for breeding I know that toward the end of his life, Alfred Nobel
that is politically manipulated. You only have to think had many doubts about his dynamite, and what it
of the Nazi German ideal, the blond blue-eyed German. would be used for.
There’s a very big distinction between the sort of WW: Let’s go back to the concerns you raised with
genetic engineering that could prevent certain dis- the United Nations, when you suggested that genetic
eases, and the possibility of breeding a different or engineering could lead to a “new racism.” How might
separate race of people. There’s always a good that can a genetic racism be manifested? Do you mean that
come out of it, but how do you control the evil? people might be manipulated to be more accepting of
WW: In some of your writing, you have pointed to the political regime?
the possibility of a two-tiered health care system in NG: Or even to have memories that block out cer-
which the rich or mostly light-skinned people have tain things.
access to the new genetic medicine, while the poor, WW: Such as…?
mostly dark-skinned people have not. NG: Well, for instance, it’s come through the Truth
NG: Yes. I was thinking particularly of my own Commission that there were plans to use drugs for
country [South Africa], and I was thinking specifically crowd control, to make people more docile. I think it’s
of AIDS. Now, among people who have money to possible you could torture somebody and then block
provide themselves with the drugs that are available to out the memory of that.
control HIV or AIDS itself, there’s a good chance to WW: Obviously we’re not talking about one tech-
go on living. But in the poor, mostly black majority of nology. As our knowledge of the genome and of neu-
our population, they simply cannot afford these drugs. rosciences expands, it opens up a whole range of
So AIDS is a death sentence for them. frightening scenarios—from crowd control to the
WW: So, you are saying that just as the anti- drugs that Aldous Huxley talked about, which could
retroviral drugs that help treat the symptoms of AIDS numb a whole society.
are only available to a small minority, any genetic NG: Yes, I suppose we have all tried in one way or
breakthrough that we are likely to see in the next few another to manipulate our consciousness—most of
decades is likely to be similarly priced and accessible us with cigarettes or alcohol or music. This is a per-
only to a few. sonal choice that you make, and you’re not forcing it
NG: We are looking at a terrible imbalance between upon other people. But if certain physical character-
the rich and the poor of the world. istics and mental attitudes can be genetically induced
WW: Sometimes we wonder whether scientists in some way, that becomes the superiority that leads
don’t simply do everything they can because that’s to some people being regarded as custodians of
what they are driven to do. If they are able to split the everybody else.
atom, they will split it. If they are able to make clones,
they will make them. Maybe it’s a part of our hubris
that we just rush forward and build whatever we can, Nadine Gordimer received the Nobel Prize in Literature
and inevitably we encounter consequences we haven’t for 1991. She has honorary degrees from Yale, Harvard,
foreseen. Columbia, and Cambridge Universities, and the University
NG: There is something wonderful about the con- of Cape Town and the Witwatersrand in South Africa.

WORLD•WATCH July/August 2002 17


Sarah Sexton
Deceptive Promises
Of Cures
For Disease
The great majority of the world’s diseases are caused by environmental,
not genetic, conditions. A frenzied search for genetic therapies
could steal resources from billions in order to serve only a few.

B
illions of public and private dollars are now being to select the best risks—people who tend to be healthy
poured into genetic research. Even some critics of anyway—and to reject those who have chronic ill-
new human genetic technologies seem to concede nesses or who cannot afford the insurance. The more
that these massive investments may be worthwhile. health care financing is based on insurance, the more
The Catholic theology professor David Tracy, for it will rely on assessments of individuals’ presumed
example, has said that “Opponents of human cloning risk of ill-health—something gene testing is poised to
(as I am) cannot afford to ignore the benefits that make enormously more complicated and supposedly
such cloning might provide for all humankind.” His accurate.
comment is easily extended to the drugs and tests that Even without widespread gene testing, about one
might be realized through the new technologies. But in six people in the United States does not have health
will the products of genetic research in fact be acces- insurance, while millions of others are underinsured.
sible to “all humankind”? With genetic screening becoming more widespread,
Probably not, because both the public and private that number will only grow, as more people are
health services that would disseminate the new drugs rejected by insurance companies or fail to keep up pre-
and procedures make cost-benefit decisions and value mium payments that will undoubtedly increase after
judgements about who should get what treatment. “susceptibilities” are discovered.
Many of the groups now considered to be the biggest Just as private health services and insurers leave out
potential beneficiaries of genetic research, such as the people who can’t pay, biotech research leaves out the
elderly and the seriously ill, are left by the wayside as illnesses from which those people suffer. Because large
treatments are rationed. In contrast, however, health numbers of the people who can’t pay suffer from trop-
services and insurance companies may vigorously pro- ical diseases, those diseases are largely ignored by
mote some products, such as prenatal and adult gene researchers. While pneumonia, diarrhea, tuberculosis,
testing, if they believe they might save the costs of and malaria account for more than one-fifth of the
supporting people in the long term. world’s disease burden, they receive less than 1 percent
Moreover, the increasing privatization of health of the funds devoted to health research. The private
care services around the world means that access to sector is not inclined to put its own money into
health care and medical products, including drugs and researching products for “financially non-solvent” peo-
tests, is increasingly based not on need but on ability ple, which is why it requires public subsidies to do so.
to pay, or to get health insurance. Private insurers tend Public funds for health care services are also in
short supply. The International Monetary Fund has
compelled many debt-ridden countries to cut back
Sarah Sexton works with The Corner House, a UK-based their public spending on health in order to be consid-
research group focusing on social and environmental justice ered eligible for loans. Those public health services
issues. She is the author of The Corner House briefing “If that still remain in these countries have been pushed
Cloning Is the Answer, What Was the Question? Power and into charging their patients “user fees.” The result?
Decision-Making in the Geneticisation of Health.” People simply use medical services less—and some-

18 WORLD•WATCH July/August 2002


cures for disease

times die of easily-treatable diseases such as tubercu- in so many parts of the world. The incidence of just
losis because they cannot afford the treatment. three leading killer diseases in the developing world—
The Philippine government now spends less than 3 malaria, diarrhea, and AIDS—would drop dramati-
percent of its budget on health—and nearly 30 percent cally if mosquito nets, clean water, and condoms were
on servicing its debt. Half of all hospital beds are now more accessible. Dr. Tikki Pang, Director of the
private, with most costs paid by patients. The insur- Research Policy & Cooperation Department at the
ance system covers only one-third of the population. World Health Organization (WHO), warns that the
Just 3 percent of the World Bank’s $1.8 billion poverty health of Africans and Asians could actually worsen as
alleviation program in the Philippines goes to fund a result of the rise of the genetic industry. While it may
health care. Of that, most be reassuring to think that sequencing the genes of the
is for projects related to parasite which causes malaria will lead to new drugs
women’s reproduction— and insecticides, it is likely, as Pang notes, that “any

NEW DRUGS MARKETED,


1975-1996

99 percent
1
pe
rc
en
t

Will genetic research be guided by need, or by ability to pay?


The increasing privatization of health care suggests the latter.
Despite the steep human and social costs of tropical disease
among the world’s poor nations, barely 1 percent of new drugs
marketed between 1975 and 1996 were aimed at malaria,
cholera, dengue fever, or other lethal maladies of the tropics.
Like pharmaceuticals, genetic technologies will be developed
mainly for the affluent.
Shehzad Noorani/ Peter Arnold, Inc.

in effect, “population management.” The World Bank such discoveries will be patented and only developed
lends more money to turn the former U.S. naval base at at prices unaffordable to those who need them most.”
Subic Bay into a “freeport” base for corporations such Similarly, studies have found that many people with
as Oriental Petroleum than it lends for Filipinos’ health. Parkinson’s disease have a history of exposure to pes-
A market-based approach to health and genetic ticides, herbicides, or industrial solvents. Yet these
research not only drives up the costs of health care, but studies have evoked little interest. Instead, media
also distracts attention from the factors that make peo- attention and legislation have been directed toward
ple ill in the first place. Spurred by the growing fasci- treatments such as customised individual tissue
nation with genes, it encourages policymakers and the replacements via human embryo cloning. In the case
public to see medicine primarily as a process of “fix- of diabetes, meanwhile, the WHO projects that inci-
ing” diseased individuals, and good health as some- dence of the disease will more than double by 2025,
thing to be bought and sold in the marketplace by with up to 300 million people affected. Obviously, we
individual consumers rather than as a political goal for cannot all suddenly be sprouting diabetes genes, and
society to work toward. even if the new research were able to pinpoint all indi-
More genetic research will do little or nothing to viduals genetically predisposed to the disease, this
alter the conditions in which people become suscepti- would do nothing to address the causes of its growing
ble to many diseases. A recent proposal to research the incidence.
gene for diarrhea, for example, ignores the social and In the area of human reproduction, the new
economic conditions that make diarrhea a child-killer genetic economy may focus on prenatal testing—while

WORLD•WATCH July/August 2002 19


the risks of the rush

neglecting the link between birth defects and, say, the and both consumers and policymakers will become
pesticides found in the fathers’ and mothers’ environ- more interested in trying to ensure that those children
ment, water, and food. Yet studying that link could who are allowed to be born are as “perfect” as possi-
have significant benefits for public health, if not for ble in the current society’s eyes.
biotech companies. European Union researchers, led But who determines who shall be born and who
by the London School of Medicine and Tropical not, and according to what criteria and what assump-
Hygiene, recently studied women living near 23 toxic tions? In the nineteenth century, no one suggested
landfill sites in Britain, Denmark, France, Belgium, that princesses of the royal families of Europe be ster-
and Italy. They found that the risk of having a baby ilized because they were carriers of the gene for hemo-
with a chromosomal abnormality such as Down’s philia. Rarely mentioned in discussions about the
increased by 40 percent for women who lived within supposed benefits for all humanity of the new genetic
two miles of a site. research is the power of dominant groups to decide
With cancer, as well, the rush to genetic solutions which diseases and conditions constitute “unaccept-
continues to dangerously divert public attention. A large able” health risks, and to determine who counts as a
majority of human cancers are influenced by carcino- “legitimate” mother.
gens in workplaces, houses, air, water, and food. The Most health inequalities cannot be attributed
overall incidence of cancer has been steadily rising in either to different genetic susceptibilities or to differ-
the industrialized world for the last 45 years—a rise that ences in medical care, and are only partially explained
cannot be explained by the increasing age of popula- by such health-related individual behavior as smok-
tions alone. In the United States, the overall age- ing, drinking, diet, and exercise. They are due rather
adjusted cancer death rate is 40 percent higher among to the effects of the different social and economic cir-
black men than white, and 20 percent higher among cumstances in which people live, including unem-
black women than white. “If you are a poor woman or ployment, poverty, poor housing, and pollution.
a black woman, your chances of contracting and dying “Much more important than the small differences
of either breast or cervical cancer are significantly higher medicine can make in survival from cancers and heart
than for other women,” says health activist April J.Tay- disease are differences in the incidence of these dis-
lor, who has worked on health issues related to black eases,” says British sociologist Richard Wilkinson, who
women for a number of years. “Many black families has long studied health inequalities within societies. All
live near toxic waste sites, have access to poor quality the broad categories of causes of death in developed
food and poor health care, and are living in immuno- countries—heart disease, respiratory illness, and can-
suppressing conditions that can cause gene mutations.” cer, all of which are main targets of biotech research—
Combining new genetic research with a market are related to income distribution. “To feel depressed,
approach to health thus exacerbates the racist aspects cheated, bitter, desperate, vulnerable, frightened,
of both. In the United States, for instance, many black angry, worried about debts or job and housing inse-
women have for decades been subjected to coercive curity; to feel devalued, useless, helpless, uncared for,
sterilization or contraception on the grounds that they hopeless, isolated, anxious, and a failure…. It is the
are “unfit” or too many or do not deserve to procre- chronic stress arising from these feelings which does
ate. Whether consciously or not, the products of the the damage,” says Wilkinson.
new genetic research are likely to be put into the serv- Even those few conditions clearly linked to single
ice of racist practice. Rutgers University legal scholar genes often cry out not so much for more genetic
Dorothy Roberts points out the danger that people research as for more attention to the environment of
will come to accept black women “being forcibly the sufferers. Consider sickle-cell disease. Chuck
implanted with Norplant or jailed because they gave Adams, a social worker in a children’s hospital in
birth to a child while addicted to drugs.” By the same Philadelphia who deals with the social problems faced
token, Roberts suggests, tests claiming that “certain by sickle-cell patients and their families, points out
children are genetically predisposed to crime” may that living in a cold, abandoned building without ade-
help justify, in the public eye, racist government pro- quate food must heavily affect those who have sickle-
grams of reproductive control. cell disease. “They just happen to have a chronic
Indeed, one of the biggest concerns associated genetic disorder,” he says, “but being poor was prob-
with the new genetic research is how neatly it rein- ably the first disorder that they had to deal with.”
forces discourses of eugenics and overpopulation. If Genetic research is yielding what is scientifically
the simple existence of 6 billion people (rather than and financially feasible, not necessarily what is needed
the actions of a small but privileged minority of those by sick people. Health for All, not Genes ’R R Us, needs
people) is believed to be destroying the planet, then to be placed at the center of public health research,
reducing those numbers becomes the top priority— policy, and funding.

20 WORLD•WATCH July/August 2002


Michael Dorsey
The
New
Eugenics
It used to be forced sterilization, and the experiments of
Dr. Mengele. Now it’s genetic technology and the free market.
The people who dream of creating a superior race are back.

O
n a not too distant hori-
zon, advances in human
biotechnology may
enable us to engineer the
specific genetic makeup
of our children. Only a few
months ago, the headline-
making Italian doctor Sev-
erino Antinori claimed to
have implanted cloned
embr yos in several
women. We are already at
the stage where we can
selectively terminate our
offspring if certain
genetic criteria are not
met. Soon it may be
possible to discern, and
ultimately select for or
against, individual
traits in our children.
It is at this junc-
ture that the promise
of biotechnology
ety

runs head-on into


ical Soci

the history and the


Philosoph

horrors of eugen-
ics—the quest for biological
American

“improvement” through reproductive control.


At the start of the 20th century, British scientist
Francis Galton coined the term eugenics, from the
Greek eugenes, for “well-born.” He later distinguished
two major kinds of eugenics, positive and negative. Michael Dorsey is Thurgood Marshall Fellow in
“Positive eugenics” was preferential breeding of so- Residence at Dartmouth College in New Hampshire.
called “superior individuals” in order to improve the He is a member of the board of directors of the Sierra
genetic stock of the human race. “Negative eugenics” Club.

WORLD•WATCH July/August 2002 21


the risks of the rush

meant discouraging or legally prohibiting reproduc- gies because people are free to
tion by individuals thought to have “inferior” genes choose them or not. The
and was to be “achieved by counseling or by steriliza- state is not involved. David
tion, either voluntary or enforced.”1* Galton, who was King, editor of the London-
Charles Darwin’s cousin, described eugenics as “the based GenEthics News, calls
science of improving stock…to give the more suitable this the emergence of lais-
races a better chance of prevailing speedily over the less sez-faire eugenics. Patients
suitable.”2 He founded the Eugenics Society in 1907 are given “non-directive”
“to spread eugenic teaching and bring human parent- genetic counseling, or
hood under the domination of eugenic ideals.”3 offered opportunities to
A popular social movement in support of such subject themselves or their
ideals had arisen in the late 19th century in the United potential children to myr-
States and Europe. This movement reached its zenith iad genetic tests, for a host
in the 1930s, but dissolved following World War II of illnesses. But as King
and the disclosure of the horrific eugenic practices of notes, such counseling is
the Nazis. Nonetheless, support for the genetic con- “eugenic both in purpose
trol of human beings did not disappear, and public and outcome, since the
endorsement of eugenic ideals continued to surface. aim is clearly to reduce
The 1962 Ciba Foundation conference, “Man and the number of births of
His Future,” is a case in point. Conference partici- children with congenital
pants, including many of the leading biotechnology and genetic disorders.”
researchers of that time, agreed that molecular biology In a 1997 survey pub-
would allow “mankind” to master evolution. Some lished in the Journal of
argued that genetic modification to encourage “posi- Contemporary Health
tive” inherited traits could be part of a broader strat- Law and Policy, re-
egy to establish a better future for humanity.4 searchers found that
A 1980 report by the European Commission’s 13 percent of English
Technology Forecasting Office provides another geneticists, 50 per-
example. The report boldly predicted: “The coming cent of Eastern and
twenty to thirty years will, it is thought, see two major Southern European
changes: the computerization of society (and)…the geneticists, and 100
biological revolution emanating from the boom of the percent of Chinese
‘life technologies.’…Within the relatively near future, and Indian geneti-
biotechnology could be used in a number of sectors: cists agreed with
we could control the development of the human the eugenic sug-
embryo, and, perhaps within twenty years, determine gestion that “an
its sex. We could prevent certain malfunctions.”5 important goal of
Some of these forecasts have since been realized, genetic counseling
and several have been exceeded.6 Sex determination is is to reduce the
not only possible, but in some places it is quite popu- number of dele-
lar—especially in cultures and nations where female terious genes in
children are “less desirable.” Prenatal diagnosis and the population.”
pre-implantation diagnosis make it possible to “select” These new
certain embryos prior to implanting them in a woman. methods of tar-
Some scientists and philosophers consider such geting and elim-
techniques to be an unmistakable reversion to eugenic inating debilitating diseases and various
practices. The trouble, they note, is that the logic of forms of inherited disabilities raise some important
eugenics—the rational management of a population ethical concerns. Few would argue against screening
for some “higher end”—is a logic readily amenable to embryos for major genetic disorders like Tay Sachs
other, far more sinister projects than those envisioned disease. But accepting the logic of eugenics in one
by “racist” and “non-racist” eugenicists, and perhaps context opens the door for justifying more controver-
by proponents of the new biotechnology. The Holo- sial practices: could parents begin to screen embryos
caust is but one case in point. for cosmetic traits like eye color? And what about
Some biotech proponents support these technolo- inheritable genetic modification, which would force
* Endnotes can be found on page 43. future generations to live with genetic alterations we

22 WORLD•WATCH July/August 2002


new eugenics

ogy, and Concentration (ETC).


A 2001 industry survey in Nature listed
361 biotech firms, more than three-quarters
of them based in the United States. These cor-
porations are, by their very nature, guided by
their bottom line. And yet, if financial consid-
erations are allowed to drive the development of
genetic technologies, we may see a rapid expan-
sion of laissez-faire eugenics.
Already, the industry almost exclusively aims
to bolster the health and well being of those who
can afford its services, in spite of using tens of mil-
lions of dollars in public monies to support basic
research. And industry lobby groups work hard to
discourage any and all forms of government regu-
lation. In the aftermath of an intense lobbying
effort in December 2001, the European Parliament
voted overwhelmingly (316 votes to 37) against
tighter restrictions on genetics and biotechnology.
A global public debate on the social implications
of biotechnologies for humanity is urgently over-
due. But few individual governments or international
agencies have stepped forward to provide leadership
for such an effort, and fewer still have called for
tighter controls and regulations. The World Health
Organization has done little to promote international
regulation of biotechnology, despite the fact that two
of its four main functions are “to give worldwide guid-
ance in the field of health” and “to develop and trans-
fer appropriate health technology, information, and
standards.” The U.N. General Assembly has embarked
on a process to obtain a global ban on reproductive
human cloning, but its passage is not assured.
Far from halting scientific progress, as some indus-
try groups claim, the imposition of moratoria or bans
on a couple of the most dangerous new human genetic
technologies could help strengthen the long-term via-
bility of basic and biomedical research by compelling
its supporters to more thoroughly consider—and
more forthrightly deal with—the social and moral
implications of their work.
ciety
ilosophical So

The 1927 Buck v. Bell decision (Oliver Wendell Holmes, Jr., wrote
the U.S. Supreme Court opinion excerpted here) centered on Emma
Buck, her daughter Carrie, and Carrie’s daughter Vivian. The first
American Ph

two women were labeled promiscuous, although Vivian was the


outcome of Carrie’s rape; all were judged “feebleminded” and
determine for them? paraded as justification for Virginia’s 1924 eugenic sterilization
In addition, targeting and eliminating those that law. One state expert testified that the Bucks were members of
might be born disabled also has deleterious implica- “the shiftless, ignorant, and worthless class of anti-social whites
tions for the living. “There is a growing voice in the of the South.” Vivian Buck turned out to be an honor-roll student.
disability movement arguing that this (type of) genetic More than 7,000 people were sterilized under Virginia’s program
research and testing fosters a climate of intolerance between 1924 and 1979. In May 2002 the state became the first of
toward people with disabilities,” according to the the 30 states that ran eugenics programs to apologize for the
Canada-based Advocacy Group on Erosion, Technol- forced sterilizations.

WORLD•WATCH July/August 2002 23


the risks of the rush

Views From
Around the World
Ethiopia slaughtered preemptively. It is this potential for geno-
cide based on genetic difference, which I have termed
Formally, the human genetic engineering project is “genetic genocide,” that makes species-altering
expected to identify our genetic peculiarities so that genetic engineering a potential weapon of mass
our ailment particularities can be precisely targeted. destruction, and makes the unaccountable genetic
But, as an African whose ancestors suffered for 500 engineer a potential bioterrorist.
years being targeted for slavery and being colonized, George J. Annas, Chair
and whose natural resources are now being plundered, Department of Health Law, Bioethics, and Human
I find it difficult to expect peculiarities to be used pos- Rights, Boston University School of Public Health
itively. When I recall that the North has apologized to
the Jews for the Holocaust and even through the Pope
to the Arabs for the Crusades, and that only in 2001
Malaysia
the North refused to apologize to Africans in Africa Potential abuse of technology related to reproductive
and the Diaspora for slavery and colonialism, I find it cloning of human beings not only raises moral, reli-
difficult to feel so positive. Given this, do I expect the gious, and ethical concerns but also poses risks [of]
human genome project to make life easier for the suf- developmental and bodily abnormalities to humans.
ferer of sickle cell anemia, or killing easier for the white Hasmy Agam
supremacist who is now a major political force in the Malaysian Ambassador, United Nations
North? I leave you to guess the answer.
Berehan Gebre Egziabher
General Manager,
India
Environmental Protection Agency, Ethiopia The final goal of reproductive engineering appears to
be the manufacture of a human being to suit exact
South Africa specifications of physical attributes, class, caste, color,
and sex. Who will decide these specifications? We have
While for privileged people it may seem that the bal- already seen how sex determination has resulted in
ance in the use of power flowing from scientific knowl- the elimination of many female fetuses. The powerless
edge and technological achievements has been in favor in any society will get more disempowered with the
of beneficence, different perceptions prevail among growth of such reproductive technologies.
those who have been marginalized. Close links Sadhana Arya, Nivedita Menon, and Jinee Lokaneeta
between science, technology, the military, money, and Saheli Women’s Resource Centre, Delhi University
those with global power, and the use of power and
secrecy to protect privilege, have undermined confi-
dence that there is any significant concern for the
North America
future of the people of Africa. Human genetic manipulation that affects indigenous
Soloman Benatar, M.D. peoples is an act of war on our children.
South Africa Dave Pratt, Dakota tribe

United States United Kingdom


Given the history of mankind, it is extremely unlikely All the developments in and around human genomics
that we will see the posthumans as equal in rights and stem from the mechanistic paradigm that still domi-
dignity to us, or that they will see us as equals. Instead, nates western science and the global society at large….
it is most likely either that we will see them as a threat The irony is that contemporary western science across
to us and thus seek to imprison or simply kill them the disciplines is rediscovering how nature is organic,
before they kill us, [or that] the posthuman will come dynamic, and interconnected. There are no linear
to see us (the garden variety human) as an inferior causal chains linking genes and the characteristics of
subspecies without human rights, to be enslaved or organisms, let alone the human condition. The dis-

24 WORLD•WATCH July/August 2002


Vandana Shiva
credited paradigm is perpetrated by a scientific estab-
lishment consciously or unconsciously serving the cor-
porate agenda, and making even the most unethical
applications seem compelling.
Mae-Wan Ho
Biopirates
Institute of Science in Society, London, U.K.
And the Poor
China
The main potential harm of genetic engineering is
associated with artificial horizontal gene transfer exper-
imentation. Horizontal gene transfer occurs com-
monly in nature. Genes can be exchanged between
different bio-species. But the frequency of these nat-
T he promise to cure disease through human genetic
engineering has moved faster on Wall Street and in
the media than in basic scientific knowledge of
how genes work and how genetic manipulation affects
whole organisms as well as their relationships with
ural transfers is limited by the defense systems, i.e. other organisms. Within a few weeks the “alphabet”
immune systems, of each bio-species. The immune of the “Book of Life” shrank from 100,000 to
system serves to prevent invasion by harmful foreign 30,000; this is just one indicator of the ocean of
genes, viruses, and so forth, so that the bio-species can ignorance in which the island of human genetic engi-
maintain its characteristic traits and normal metabo- neering is floating.
lism. The GE method of horizontal gene transfer The three major concerns arising from human
works by penetrating or weakening the immune sys- genetic engineering are biopiracy, the transformation
tem and using virulent genes as delivery vehicles. That of socially defined traits into biologically defined ones,
is, the gene to be transferred is combined with a viru- and the issue of privacy.
lent gene to effect penetration. This method allows Across the world, indigenous communities are out-
harmful virulent genes, especially those with resist- raged at biopiracy of genes and genetic material. The
ance to antibiotics, to become widespread in nature…. recent case of collection of blood samples from the
If such virulent genes combine with the genes of Naga tribe in northeast India is just another example
harmful viruses to form new viruses, it will be disas- of gene piracy at the human level. Such piracy can
trous for humankind. even happen in the heart of rich industrial society, as
Yifei Zhu shown by the case in which University of California
Hangzhou, Zhejiang Province, China scientists patented the genes of a cancer patient, John
Moore, without his knowledge.
Environmental NGOs What is called a deficiency—mental, physical, or
other—is socially defined. For example, the perverse
Together with proposed techniques of inheritable gene
world order of globalization dictated by commerce,
modification, the use of cloning for reproduction
greed, and profits regularly treats women, children,
would irrevocably turn human beings into artifacts. It
and poor people as inferiors. Without strong democ-
would bring to an end the human species that evolved
racy and true transparency, this kind of discrimination
over the millennia through natural evolution, and set
can be used to justify human genetic manipulation,
us on a new, uncontrollable trajectory of manipulation,
manifested in eugenics programs.
design, and control.
Brent Blackwelder, President, Friends of the Earth Human genetic engineering also raises major issues
Mark Dubois, International Coordinator, about the erosion of privacy and handing people’s
Earth Day 2000 control over their own destiny to others, such as insur-
Randy Hayes, President, Rainforest Action Network ance companies, pharmaceutical companies, and police
Robert F. Kennedy Jr., President, states, which could combine to share genetic data
Waterkeeper Alliance without the consent and participation of the persons
John A. Knox, Executive Director, concerned.
Earth Island Institute
Robert K. Musil, Executive Director,
Physicians for Social Responsibility
Vandana Shiva is a physicist and environmental activist
John Passacantando, Executive Director,
and is director of the Research Foundation for Science, Tech-
Greenpeace USA
Michele Perrault, International Vice President, nology, and Ecology in Uttar Pradesh, India. Her books
Sierra Club include Water Wars: Privatization, Pollution, and Profit
Mark Ritchie, President, Institute for Agriculture (South End Press, 2002) and Stolen Harvest: The Hijacking
and Trade Policy of the Global Food Supply (South End Press, 2000).

WORLD•WATCH July/August 2002 25


Judith Levine
What Human Genetic
Modification Means
For Women
Supporters of the new eugenics want it framed as an issue of “choice.”
But feminists know we can support abortion rights
and still oppose eugenics.

S
educed by the medical promises of genetic science of one woman’s egg is transferred into the egg of
or fearful of losing reproductive autonomy, many another woman who is having difficulty sustaining
feminists have been slow to oppose human genetic embryo survival. The transferred cytoplasm contains
engineering. But GE is a threat to women, and in mitochondria (organelles that produce energy for the
the broadest sense a feminist issue. Here’s why. cell), which have a small number of their own genes. So
If anyone should be wary of medical techniques to the embryo produced with cytoplasmic transfer can
“improve” ordinary reproduction—as GE purports to end up with two genetic mothers. This mixing, called
do—it’s women. History is full of such “progress,” “mitochondrial heteroplasmy,” can cause life-threat-
and its grave results. When limbless babies were born ening symptoms that don’t show up until later in life.
to mothers who took thalidomide, the drug was When the Public Broadcasting Service’s Nova enthusi-
recalled. But the deadly results of another “pregnancy- astically reported on the procedure, complete with
enhancing” drug, DES, showed up only years later, as footage of its cute outcome, Katy, it mentioned no
cancer in the daughters of DES mothers. The high- risks.
estrogen Pill was tested first on uninformed Puerto Didn’t these patients give informed consent? Yes
Rican mothers, some of whom may have died from it. and no. Most read warnings and signed their names.
Today’s fertility industry takes in $4 billion a year, But with genetic therapies there’s no such thing as
even though in-vitro fertilization (IVF) succeeds in “informed,” says Judy Norsigian of the Boston
only 3 of 10 cases. Virtually unregulated and highly Women’s Health Collective, “because the risks can’t
competitive, these fertility doctors often undertake be known.” Adds biologist Ruth Hubbard, the dead-
experimental treatments. Recently, the Institute for liness of DES was discovered “only because it showed
Reproductive Medicine and Science at New Jersey’s itself in an otherwise very rare condition. If the effects
St. Barnabas Medical Center announced the success of [of human genetic engineering] are delayed, and if
a new fertility “therapy” called cytoplasmic transfer, in they are not associated with a particularly unusual
which some of the cellular material outside the nucleus pathology, it could take quite a long time to find

out.” Or indeed, “we might never know.”


Judith Levine has written on women’s issues for Ms., My Gen-
eration, New York Woman, Oxygen, and Salon, among others. “PERFECTING” HUMAN GENETIC MODIFICATION
She is the author of My Enemy, My Love: Women, Men, and WOULD REQUIRE EXPERIMENTATION
the Dilemma of Gender (Anchor Doubleday, 1993), and ON WOMEN AND CHILDREN.
Harmful to Minors: the Perils of Protecting Children From Scottish biologist Ian Wilmut, the “father” of the
Sex (University of Minnesota Press, 2002). famously first-cloned sheep Dolly, provided these sta-

26 WORLD•WATCH July/August 2002


women

The Role of North American Women


Mainstream American women’s and reproductive rights Republicans like Florida Congressman David Weldon
organizations have been slow to understand species- and Pennsylvania’s James Greenwood, and the bills’
altering technologies as their issues. This hasn’t been loudest supporters were anti-abortion fundamentalists.
true in Europe and the global South, or among indige- This demanded fast and tricky politicking. The
nous women in North America. In 1992, for instance, sponsors’ sympathies, showing more tenderness toward
European Green Party women discovered a patent blastocysts than toward living women and children,
application from a U.S. biotech company for a process made pro-choice representatives want to run in the
to synthesize nonhuman “biological active agents” in other direction. “The problem with the Weldon bill was
human mammary glands, from which they’d be secreted Dave Weldon,” said Judy Norsigian, executive director
in milk and transmitted to nursing infants. To dramatize of the Boston Women’s Health Collective, after
the commodification of women that lurked in this idea, lobbying the House on behalf of that bill. The press
the women’s propaganda featured the image of a fanned moderates’ misgivings by characterizing the
pregnant belly with a bar code emblazoned across it. It debate as one of science versus religion, or of medical
was one of the first feminist campaigns against patenting progress versus Luddite alarmism.
a life form, and it was successful. But if such success is Last summer, U.S. feminists began to catch up. More
to have any chance of being parlayed into a comprehen- than 100 groups and individuals—from the National
sive global ban, given the aggressive rush of U.S. indus- Women’s Health Network to the National Latina Health
try toward this lucrative new trade, more active Organization, and from disability rights feminist Adrienne
intervention will be needed from Americans—and espe- Asch to anti-globalization activist Naomi Klein—signed
cially from American women. the Boston Women’s Health Collective petition
When proposals to ban human cloning were supporting a ban on reproductive cloning and a morato-
introduced in the U.S. House of Representatives a year rium on embryo cloning. The leadership of the Health
ago, progressive opponents of genetic engineering were Collective’s executive director was emblematic as well as
only partly pleased. The problem was, the legislation did real: as the prospect of human genetic engineering looms,
not come from other progressives, or their friends. the title of the feminist classic her group wrote—Our
Rather, the bills were all sponsored by hard-right Bodies, Ourselves—assumes more urgent meaning.

tistics in 2001: Of the 31,007 sheep, mice, pig, and Valhalla, is that if it works on a mouse, it is likely not
other mammal eggs that had undergone somatic cell to work on a woman: “Every species presents a new set
nuclear transfer (cloning), 9,391 viable embryos of problems.” How might the process be perfected in
resulted. From those embryos came 267 live-born off- humans? In clinical trials?
spring. In these animals, The New York Times reported, “The degree of risk to be taken should never
“random errors” were ubiquitous—including fatal exceed that determined by the humanitarian impor-
heart and lung defects, malfunctioning immune sys- tance of the problem to be solved by the experiment,”
tems, and grotesque obesity. In all, “fewer than 3 per- reads the Nuremburg Code, drawn up after World
cent of all cloning efforts succeed.” Dolly may be a War II to forbid future torturous experiments of the
victim of accelerated aging, another problem in cloned sort Nazi “scientists” inflicted on concentration-camp
animals. In January, it was reported that she has arthri- inmates. What is the humanitarian importance of cre-
tis, at the unusually early age of five and a half. Moth- ating a faster 100-meter sprinter? Or even curing a
ers of clones are endangered too, since their bodies disease with genetic engineering when other options
have trouble supporting the abnormally large fetuses are still untried? The science to find “safe” means of

that cloning often produces. human GE, says Newman, would constitute “an
It’s likely that scientists will get better at cloning entirely experimental enterprise with little justifica-
animals, and at the more complex procedures required tion.” In other words, “We can’t get there from here.”
to produce inheritable genetic alterations. Then, as
health activists quip, if it works on a mouse, they will WE ARE NOT OUR GENES.
try it on a woman. The problem, warns Stuart New- When the Human Genome Project finished its map of
man, a cell biologist at New York Medical College in our DNA, its press releases called it the “blueprint” of

WORLD•WATCH July/August 2002 27


the risks of the rush

humanity, the very Book of Life. The newspapers had the paying customers, if not for their unsuspecting
already been filling up with reports of the discovery of offspring). The Book of Life is becoming a “cata-
a “gene for” breast cancer, and a “gene for” gayness. logue” of “consumer eugenics,” says sociologist Bar-
Many people had begun to believe our genes deter- bara Katz Rothman.
mine who we become. Some ethicists, too, have posited a reproductive
This line of thinking should sound familiar to “right” to prenatal baby design. People decide
women. Not long ago, we were told that hormones, whether or not to reproduce based on an expected
not sexism, explained why there has never been a U.S. “package of experiences,” wrote John Robertson, an
female president (she might start a nuclear war in a fit influential bioethicist, in 1998. “Since the makeup of
of PMS). A decade after that came the notion that the packet will determine whether or not they repro-
gender is “hard-wired” into the brain. Not inciden- duce…some right to choose characteristics, either by
tally, these claims were made just when social move- negative exclusion or positive selection, should follow
ments were proving Simone de Beauvoir’s adage that as well.” Already, selective abortion is widely accepted
women are not born but made. Now the old deter- after prenatal genetic screening uncovers an “anom-
minism is raising its ugly head once again, with genet- aly.” Although some (notably disability rights activists)
ics. As “non-traditional” families finally bring critique such “negative eugenics,” many people accept
legitimacy to social parenting, proponents of inherit- this practice for serious medical conditions. In any
able genetic modification tell us not only that we can case, selecting from among a small number of embryos
pre-determine the natures of our children, but that is a far cry from rearranging the DNA of a future child
cloning is the only means by which gays and lesbians to achieve some preferred traits.
can become real parents. “Real” parental ties, they What feminists mean by “choice”—the ability to
imply, are biological, genetic. control fertility with safe and legal birth control and
“Genetic determinism” is not biologically accu- abortion—is far more concrete. It confers existential
rate. “It is very unlikely that a simple and directly equality on the female half of the human race, which
causal link between genes and most common diseases is why women worldwide have sought it for centuries.
will ever be found,” writes Richard Horton, editor of But genetic engineering designs in inequality: it will
the British medical journal The Lancet. If this is true of artificially confer heritable advantages only on those
disease, it is even more true of musicality, optimism, or who can afford to buy them. Performed prenatally,
sexual orientation. The more complex a trait, the less moreover, it affects the new person without that per-
useful genetics are to explain it. Hubbard writes, “The son’s prior consent and possibly to her physical or
lens of genetics really is one of the narrowest foci to emotional detriment. “Ending an unwanted preg-
define our biology, not to mention what our social nancy is apples, and mucking around with genes is
being is about.” oranges,” says Marcy Darnovsky of the Center for
Genetics and Society. “We support abortion rights
GENETIC MODIFICATION IS NOT because we support a right to not have a child—or to
A REPRODUCTIVE “CHOICE.” have one. But we don’t support a woman’s right to do
For feminists, one of the most galling aspects of the anything to that child once it’s alive, like abuse it or kill
debate about human genetic manipulation is the way it.” Ironically, as Lisa Handwerker of the National
its proponents have hijacked the language of “choice” Women’s Health Network has pointed
to sell its products. IVF clinics and biotech research out, anti-choice, anti-GE forces
shouldn’t be regulated, say the companies that run share with GE’s proponents
them, because that would impinge on “choice” (for an obsessive focus

Thousands of cloning experiments on mammals have yielded these on the embryo as an independent entity, while they
results so far: for every 3.3 cloned eggs, 1 viable embryo, and for both virtually ignore the pregnant woman and the
every 35 viable embryos, 1 live-born offspring. Ratio of eggs to live child she may bear.
offspring: about 116 to 1. Most of the offspring suffered from grave
defects. To get better at cloning will require much more BANS ON DANGEROUS GENETIC TECHNOLOGIES
experimentation. To get good at cloning humans, or performing other DO NOT GIVE FETUSES “RIGHTS.”
genetic operations on them, will require experimenting on women, Some choice advocates fear that any perceived concern
men, and children—and accepting the inevitable failures. about embryos will cede territory to anti-abortionists,

28 WORLD•WATCH July/August 2002


women

who want full legal protection of embryos and fetuses. too. Baird offered the example of overfishing, which
U.S. Congressman Henry Waxman reflected this con- might benefit the fisherman in the short run but
fusion when he said at a Congressional hearing, “I do deplete the fishery for everyone, including that fisher-
not believe that the Congress should prohibit poten- man, in the long run. Regulation sustains his and his
tially life-saving research on genetic cell replication children’s livelihoods. “We all have a stake in the kind
because it accords a cell—a special cell, but only a of community we live in,” Baird said.
cell—the same rights and protections as a person.”
But pro-choice opponents of cloning do not pro- FEMINISTS CAN WORK ALONGSIDE
pose to give cells rights. Rather, we worry that cloned ANTI-ABORTION CONSERVATIVES AGAINST
embryos might be implanted by unscrupulous fertility SPECIES-ALTERING PROCEDURES.
entrepreneurs into desperate women, where they’ll “We are repelled by the prospect of cloning human
grow into cloned humans. And from cloning, it is not beings…because we intuit and we feel, immediately
a big step to designing children. and without argument, the violation of things that we
For legal, political, and philosophical reasons, Uni- rightfully hold dear,” wrote Leon Kass, conservative
versity of Chicago medical ethicist Mary Mahowald social critic and chair of President Bush’s committee to
proposes clarifying the pro-choice position. “It does investigate stem-cell research.
feminist support for abortion no good to confuse life Not every feminist holds dear what Kass holds
with personhood,” she told me. “We can admit that dear: the “sanctity” of the family based in God-given,
the embryo is life and therefore afford it respect—the “natural” forms of reproduction. Still, Kass sat beside
respect, for instance, of not exchanging its genes with Judy Norsigian and Stuart Newman to testify
those of another cell. But respecting life is not the before the U.S. Congress against cloning.
same as granting rights. Rights are reserved for living The genetic engineering debate has made
persons.” strange bedfellows. But it has also rearranged
the political definitions that made those bed-
INDIVIDUAL FREEDOM MUST BE BALANCED fellows strangers. “Social conservatives
WITH SOCIAL JUSTICE. believe [genetic engineering] is
“We’re against bans,” said a member of a coalition playing God and therefore
of mainstream reproductive-rights groups, explaining unethical, while anti-biotech
why the coalition was reluctant to join a campaign activists [of the Left] see it
against human cloning. This reaction is not surprising
in the United States, where defense of personal free- as the
dom can often trump the public first step into a
interest. brave new world
Women’s liberation means divided by biologi-
more than personal freedom, cal castes,” writes
though. Rooted in social critic Jeremy Rifkin. “Both
the Left, oppose the emergence of a commercial eugen-
ics civilization.” Others suggest that the new
political landscape divides differently, between
feminism is a libertarians and communitarians. Whether of the
critique of all Left or the Right, the former would support an indi-
kinds of domination and there- vidual right to choose just about any intervention on
fore a vision of an egalitarian world—racially one’s own body or one’s offspring, whereas the latter
and economically, as well as sexually. esteem public health and social equality and would
In the case of species-altering procedures, reject those interventions, including GE, that endan-
social justice must prevail over individual “choice.” ger them.
Arguing for an international ban on reproductive Choice activists may at first be surprised when they
cloning and regulation of related research, Patricia find that their anti-cloning and anti-eugenics senti-
Baird, chair of Canada’s Royal Commission on New ments are shared by opponents of reproductive rights.
Reproductive Technologies, put it this way: “The But passionate arguments for the same position from
framework of individual autonomy and reproductive historically sworn enemies can only make a legislator,
choice is dangerously incomplete, because it leaves out or any citizen, listen up. Feminists need sacrifice no
the effects on others and on social systems, and the part of the defense of women’s reproductive auton-
effects on the child and future generations.” The good omy when we champion health and social justice for
news is that good public policy protects individuals the future human community.

WORLD•WATCH July/August 2002 29


Francis Fukuyama
In Defense of Nature,
Human and
Non-Human
If the problem of unintended consequences is severe in the case of
non-human ecosystems, it will be far worse in the realm of human genetics.
GMOs are ultimately only an opening shot in a larger revolution.

P
eople who have not been paying close attention boasting of the replacement of natural spaces with
to the debate on human biotechnology might steel, concrete, and electricity. This victory over
think that the chief issue in this debate is about nature was short-lived: in the past generation, no
abortion, since the most outspoken opponents developed country has undertaken a new large hydro-
of cloning to date have been right-to-lifers who electric project, precisely because we now understand
oppose the destruction of embryos. But there are the devastating eco-
important reasons why cloning and the genetic tech- logical and social con-
nologies that will follow upon it should be of concern sequences that such NUMBER OF GENES
to all people, religious or secular, and above all to undertakings pro- Whatever the measure of
those who are concerned with protecting the natural duce. Indeed, the man is, it’s not the sheer
environment. For the attempt to master human nature environmental move- number of genes. Before
through biotechnology will be even more dangerous ment has been active the human genome was
and consequential than the efforts of industrial soci- in trying to persuade decoded, biologists
eties to master non-human nature through earlier gen- China to desist from expected the gene total to
erations of technology. pursuing the enor- reach 100,000. In fact, a
If there is one thing that the environmental move- mously destructive
ment has taught us in the past couple of generations, Three Gorges Dam.
it is that nature is a complex whole. The different parts If the problem of
of an ecosystem are mutually interdependent in ways unintended conse-
that we often fail to understand; human efforts to quences is severe in
manipulate certain parts of it will produce a host of the case of non-
unintended consequences that will come back to human ecosystems, it
haunt us. will be far worse in
Watching one of the movies made in the 1930s the realm of human Fruit fly
about the construction of Hoover Dam or the Ten- genetics. The human
nessee Valley Authority is today a strange experience: genome has in fact
the films are at the same time naïve and vaguely Stal- been likened to an
inist, celebrating the human conquest of nature and ecosystem in the com-
plex way that genes
interact and influence
Francis Fukuyama is Bernard Schwartz Professor of Inter- one another. It is now
national Political Economy at The Johns Hopkins University estimated that there
School of Advanced International Studies. He is the author are only about 30,000
of The End of History (Free Press, 1992), and Our Posthu- genes in the human
man Future: Consequences of the Biotechnology Revolu- genome, far fewer
tion (Farrar, Straus, and Giroux, 2002). than the 100,000
✦ © Taina Litwak

30 WORLD•WATCH July/August 2002


in defense of nature

believed to exist until recently. This is not terribly debility in old age, or some other completely unex-
many more than the 14,000 in a fruitfly or the 19,000 pected side effect that may emerge only after the
in a nematode, and indicates that many higher human experimenters have passed from the scene.
capabilities and behaviors are controlled by the com- Listening to people in the biotech industry talk
plex interworking of multiple genes. A single gene about the opportunities opening up with the com-
will have multiple effects, while in other cases several pletion of the sequencing of the human genome is
genes need to work together to produce a single effect, eerily like watching those propaganda films about
along causal pathways that will be extremely difficult Hoover Dam: there is a hubristic confidence that
to untangle. biotechnology and scientific cleverness will correct
The first targets of genetic therapy will be rela- the defects of human nature, abolish disease, and per-
tively simple single gene disorders like Huntington’s haps even allow human beings to achieve immortality
disease or Tay Sachs disease. Many geneticists believe some day. We will come out the other end a superior
that the genetic causality of higher-order behaviors species because we understand how imperfect and
and characteristics like personality, intelligence, or even limited our nature is.
height is so complex that we will never be able to I believe that human beings are, to an even greater
manipulate it. But this is precisely where the danger degree than ecosystems, complex, coherent natural
lies: we will be constantly tempted to think that we wholes, whose evolutionary provenance we do not
understand this causality better than we really do, and even begin to understand. More than that, we possess
will face even nastier surprises than we did when we human rights because of that specifically human
tried to conquer the non-human natural environment. nature: as Thomas Jefferson said at the end of his life,
In this case, the victim of a failed experiment will not Americans enjoy equal political rights because nature
be an ecosystem, but a human child whose parents, has not arranged for certain human beings to be born
seeking to give her greater intelligence, will saddle her with saddles on their backs, ready to be ridden by their
with a greater propensity for cancer, or prolonged betters. A biotechnology that seeks to manipulate
human nature not only risks
unforeseen consequences, but can
human has only about undermine the very basis of equal
30,000 (the same as a Rendering of man from
democratic rights as well.
plaque on Pioneer 10, first
mouse). And a rice plant man-made object to escape So how do we defend human
has even more genes than the solar system
nature? The tools are essentially
a human (about 40,000). 30,000
the same as in the case of protect-
Our genes help make us ing non-human nature: we try to
human, but their numbers shape norms through discussion
are not the whole story. and dialogue, and we use the
power of the state to regulate the
way in which technology is devel-
oped and deployed by the private
Plant-parasitic sector and the scientific research
nematode 20,000
community. Biomedicine is, of
course, heavily regulated today,
Genes per organism

but there are huge gaps in the


jurisdiction of those federal agen-
cies with authority over biotech-
nology. The U.S. Food and Drug
Administration can only regulate
food, drugs, and medical products
10,000 on the basis of safety and efficacy.
It is enjoined from making deci-
sions on the basis of ethical con-
siderations, and it has weak to
nonexistent jurisdiction over med-
ical procedures like cloning,
preimplantation genetic diagnosis
(where embryos are screened for
0 genetic characteristics before being
Courtesy USDA and Florida Department of Agriculture Courtesy NASA ✦

WORLD•WATCH July/August 2002 31


the risks of the rush

implanted in a womb), and germline engineering which genes of different individuals and sometimes
(where an embryo’s genes are manipulated in ways species were spliced together, initially in agricultural
that are inherited by future generations). The National biotechnology and later in areas like human gene ther-
Institutes of Health (NIH) make numerous rules cov- apy. A conference held in 2000 on the 25th anniversary
ering human experimentation and other aspects of sci- of Asilomar led to a general consensus that, whatever
entific research, but their authority extends only to the virtues of the RAC a generation ago, it had out-
federally funded research and leaves unregulated the lived its usefulness. The RAC has no enforcement
private biotech industry. The latter, in U.S. biotech powers, does not oversee the private sector, and does
firms alone, spends over $10 billion annually on not have the institutional capability to even monitor
research, and employs some 150,000 people. effectively what is happening in the U.S. biotech
Other countries are striving to put legislation in industry, much less globally. Clearly, new regulatory
place to regulate human biotechnology. One of the institutions are needed to deal with the upcoming
oldest legislative arrangements is that of Britain, which generation of new biotechnologies.
established the Human Fertilisation and Embryology Anyone who feels strongly about defending non-
Agency more than ten years ago to regulate experi- human nature from technological manipulation should
mentation with embryos. Twenty-four countries have feel equally strongly about defending human nature as
banned reproductive cloning, including Germany, well. In Europe, the environmental movement is more
France, India, Japan, Argentina, Brazil, South Africa, firmly opposed to biotechnology than is its counter-
and the United Kingdom. In 1998, the Council of part in the United States, and has managed to stop the
Europe approved an Additional Protocol to its Con- proliferation of genetically modified foods there dead
vention on Human Rights and Dignity With Regard in its tracks. But genetically modified organisms are
to Biomedicine banning human reproductive cloning, ultimately only an opening shot in a longer revolution,
a document that has been signed by 24 of the coun- and far less consequential than the human biotech-
cil’s 43 member states. Germany and France have pro- nologies now coming on line. Some people believe
posed that the United Nations draft a global that, given the depredations of humans on non-human
convention to ban reproductive cloning. nature, the latter deserves more vigilant protection.
One of the early efforts to police a specific genetic But in the end, they are part of the same whole. Alter-
technology, recombinant DNA experiments, was the ing the genes of plants affects only what we eat and
1975 Asilomar Conference in California, which led to grow; altering our own genes affects who we are.
the establishment under the NIH of the Recombinant Nature—both the natural environment around us, and
DNA Advisory Committee (RAC). The RAC was sup- our own—deserves an approach based on respect and
posed to approve all recombinant experiments in stewardship, not domination and mastery.

Rosario Isasi
The Human Rights Perspective

G enetic engineering could be used to “enhance”


human beings, to make them healthier, smarter,
more athletic and attractive—and probably also
taller, thinner, and lighter-skinned. Advocates enthu-
siastically champion a disease- and suffering-free
Conditioning lives by manipulating individuals’
genes for the sake of parental ambition contradicts the
very notion of autonomy. Genetic engineering also
assaults human dignity and universal human rights
and runs counter to democratic ideals. In 1997
human being, perhaps even an immortal one. But in UNESCO unanimously adopted the Universal Dec-
this scenario, markets will supersede human rights, laration on the Human Genome and Human Rights,
supply and demand will determine the value of each which reaffirms the fundamental principles enshrined
person, and economics will dictate which traits in the International Bill of Human Rights: “The
should be adopted. human genome underlies the fundamental unity of all
members of the human family, as well as the recogni-
tion of their inherent dignity and diversity…. It is
Rosario Isasi is from Peru and is a health-law fellow at the the heritage of humanity.”
Boston University School of Public Health.

32 WORLD•WATCH July/August 2002


Tom Athanasiou and Marcy Darnovsky
The Genome
as a
Commons
Through all the trials and tribulations of human history,
what binds us in the end is our common humanity.

T
he atmosphere. The oceans eases, optimized height and
and fresh waters. The land weight, and increased intelli-
itself, and the fruits and gence. Farther off, but within
grains our forebears bred the lifetimes of today’s children,
and cultivated upon it. The they foresee the ability to adjust
broadcast spectrum. The atten- personality, design new body
tion spans of our children. forms, extend life expectancy,
Does such a list adequately and endow hyper-intelligence.
evoke “the commons,” and the Some actually predict splicing
stakes we face in trying to save traits from other species into
it—both for itself and as the human children: in late 1999,
foundation of our common future? for example, a Ted Koppel/ABC Nightline special on
Or must we add yet another, more shocking exam- cloning speculated that genetic engineers will eventu-
ple? Perhaps we must put the human genome itself on ally design children with “night vision from an owl”
this endangered commons list, and note that if this and “supersensitive hearing cloned from a dog.”
genetic commons too is lost to partition and privati- There are dark portents here in profusion, and
zation, if it too becomes the privilege of the affluent, many of them will seem familiar to environmentalists.
then none of us on either side of the divide can be sure But consider first the fundamental point: our patently
of retaining the “humanity” we like to think we’ve inadequate ability to protect the resources of the
achieved. global commons, to do them justice, to make them (in
The biotech boosters, of course, don’t see things reality as well as in United Nations rhetoric) “the com-
this way. Many of them insist that any conceivable mon heritage of humankind.” Consider, through this
application of human genetic engineering is essential lens, the likely fate of the human genome—the script
to medical progress, and that the possibilities, no mat- which unites us as a biological species—as it too goes
ter how speculative, trump all other considerations. on the auction block.
Thus they shrug off the likely outcome of embryo And attend to this chilling bit of futurology from
cloning—that it will sooner or later lead to reproduc- Lee Silver, a Princeton professor and self-appointed
tive cloning, and then jump-start both the technolo- champion of the new techno-eugenics:
gies and justifications of inheritable genetic
modification.
Some of them are even enthusiastically promoting Tom Athanasiou is the author of Divided Planet: The
“designer babies” and “post-humans” as the next new Ecology of Rich and Poor (Little, Brown, 1996). Marcy
things.1* Indeed, the techno-eugenic hard school is Darnovsky is Associate Executive Director of the Center for
now promising that, within a generation, “enhanced” Genetics and Society, and was editor (with Barbara Epstein
babies will be born with increased resistance to dis- and Richard Flacks) of Cultural Politics and Social
* Endnotes can be found on page 43. Movements (Temple University Press, 1995).

WORLD•WATCH July/August 2002 33


the risks of the rush

“[In a few hundred years] the GenRich—who do not find in any of these possibilities reason to
account for 10 percent of the American population— forego eugenic engineering. In Children of Choice, for
[will] all carry synthetic genes…. All aspects of the example, John Robertson writes that genetic enhance-
economy, the media, the entertainment industry, and ments for the affluent are “simply another instance in
the knowledge industry [will be] controlled by mem- which wealth gives advantages.”3
bers of the GenRich class…. Naturals [will] work as So ask not if the techno-eugenic agenda will come
low-paid service providers or as laborers…. [Even- true anytime soon. Ask instead why it’s getting so
tually] the GenRich class much air time, and why Silver
and the Natural class will and the others have not been
become…entirely separate taken even mildly to task, either
species with no ability to cross- by their scientific colleagues or
breed, and with as much by liberal and progressive intel-
romantic interest in each other lectuals who might be expected
as a current human would have to muster a bit of angst over
for a chimpanzee.”2 such crass eugenic visions.
Silver’s predictions, in case And they are crass. Note the
this isn’t clear, are not voiced coarse neoliberalism that
in opposition to a eugenically underlies Silver’s certainty
engineered future. Here and about the eugenic future:
elsewhere, his tone alternates “There is no doubt about it,”
between frank advocacy of a he writes, “whether we like it or
new market-based eugenics not, the global marketplace will
and disengaged acceptance of reign supreme.”4 Moreover: “If
its inevitability. the cost of reprogenetic tech-
Is such a future likely? We nology follows the downward
hope not, and we take some path taken by other advanced
comfort in the possibility that technologies like computers
scenarios like these may long and electronics, it could
remain beyond technical reach. become affordable to the
Notwithstanding the flesh- majority of members of the
and-blood accomplishments of middle class in Western soci-
genetic scientists—glow-in- eties…. And the already wide
the-dark rabbits and goats that gap between wealthy and poor
lactate spider silk—artificial nations could widen further
genes and chromosomes may never work as reliably as and further with each generation until all common
advertised. Transgenic designer babies may be too rid- heritage is gone. A severed humanity could very well
dled with unpredictability or malfunction to ever be the ultimate legacy of unfettered global capital-
become a popular option. ism.” 5
Still, both the technological drift and the strength of The techno-eugenic vision carries with it a deep
ideological feeling among proponents compel us to take ideological message. It urges us, in case we still harbor
the prospect of a techno-eugenic future seriously. Some vague dreams of human equality and solidarity, to get
surprisingly influential figures—including controversial over them. It tells us that science, once (and some-
celebrities like Nobel laureate James Watson and times still) the instrument of enlightenment and eman-
philosopher-provocateur Peter Singer, as well as main- cipation, may bequeath us instead a world in which
stream academicians like Daniel Koshland of U.C. class divisions harden into genetic castes, and that
Berkeley and John Robertson of the University of there’s not a damn thing we can do about it. The
Texas—are publicly endorsing visions similar to Silver’s. story of an “enhanced” humanity panders to some of
These boosters frankly acknowledge that designer- the least attractive tendencies of our time: techno-sci-
baby techniques would be very expensive and that entific curiosity unbounded by care for social conse-
most cloned or genetically “enhanced” children would quence, economic culture in which we cannot draw
be born to the well-off. They concede that the tech- lines of any kind, hopes for our children wrought into
nologies of human genetic redesign would therefore consumerism, and deep denial of our own mortality.
significantly exacerbate socio-economic inequality, and This last theme, the one that brings our life
they speculate about a future in which a genetic elite expectancies and bodily functions to center stage, is a
acquires the attributes of a separate species. But they powerful one. Its driver is medical biotech, and the

34 WORLD•WATCH July/August 2002


commons

market niche for it is clearly waiting: all those aging issue and the Alice-in-Wonderland quality of the
boomers now avidly dropping Viagra and DHEA and debate about it: the out-on-a-limb promises of near-
Human Growth Hormone are the natural con- term cures (would that Christopher Reeve, a
stituency of the techno-eugenicists. Tell them that spokesman for therapeutic cloning, could be Super-
they’ll live longer, and they’ll follow you anywhere. As man again); the overblown claims of research break-
James Watson put it in a conversation about how to throughs (those cloned human embryos? Actually,
convince the public that eugenic manipulation of they stopped dividing at six cells); the loose talk of
future children is treating millions of
acceptable, “We can sufferers with “thera-
talk principles for- peutic” cloning (after,
ever, but what the of course, finding the
public actually wants women to “donate”
is not to be sick. And millions of eggs).
if we help them not Biomedicine’s dis-
be sick they’ll be on pensation from the
our side.”6 precautionary princi-
Watson, unfortu- ple may also shed
nately, is tuned to the light on another odd-
zeitgeist of the well- ity. Pundits in the
off and the well- United States, noting
funded. Those of that both pro-choice
us disinclined to liberals and conserva-
embrace eugenic tives are now voic-
engineering will have ing caution about
to work harder to be embryo cloning, are
heard above the din suddenly fixated on
of wildly exaggerated the “strange bedfel-
biomedical claims. It lows” that make up
won’t be easy, but the bottom line is clear enough: we the anti-cloning lobby. Yet they’ve entirely overlooked
have to distinguish genetic techniques that are plausi- the more disturbing lapses that still characterize so
ble and appropriate from those that are likely to be much of the liberal/progressive reaction to the
unsafe, ineffective, unjust, and pernicious. prospect of unrestricted human biotechnology.
The history of environmentalism is instructive What, for example, are we to make of a recent
here. Advocates of ecological sanity have for decades comment (made in an off-the-record meeting of a
expended oceans of sweat and tears to show the need national progressive organization) that “we don’t ban
for caution in the face of powerful new technologies— things—bad guys ban things”? What about ozone-
nuclear power plants, large dams, Green Revolutions. depleting chemicals, above-ground nuclear testing,
To be sure, the precautionary principle is generally and medical experimentation on inadequately
swatted aside by powerful political and economic informed women in the global South? And what of a
interests, but many people, and a few courageous pol- new eugenics based on high-tech reproduction, con-
icy makers, have accepted its key assumption: that sumer preferences, and market dynamics? If we don’t
technologies shape lives and societies and thus are ban these things, who will?
appropriate matters for both careful forethought and And what are we to think when a columnist in an
democratic oversight. intelligent liberal journal like The American Prospect
This elementary precautionary lesson, however, is opines that “humans are part of the natural world and
seldom applied to medical technologies. Even those all their activities, science, cloning, and otherwise, are
desensitized to the sirens’ song of triumphant techni- therefore hardly unnatural, even if they may be
cal progress may find themselves dreaming of new unprecedented.”7 Surely environmentalists have been
therapies, fountains of youth, and genetically enhanced adequately warned against the naturalistic fallacy and
memories. We may nurse, if only in the backs of our are well aware that appeals to “Nature” can be made
minds, the comforting assurance that this is all moving to justify anything. So aren’t we entitled to a similar
too quickly to be stopped. level of sophistication from those inclined to see “Lud-
The near-exemption of biomedical technologies dites” behind every bioengineered bush? Surely even
from the principles of precaution may help explain the liberals who staunchly maintain their faith in the
sudden emergence of embryo cloning as a national onward march of science can see the political dangers

WORLD•WATCH July/August 2002 35


of conflating categories, of erasing the difference Which brings us back to the rich and the poor,
between the products of millions of years of evolution and their respective claims on the various global com-
and the products of commerce and fashion. mons. Any serious vision of the future must address
When liberals throw in their lot with libertarians, this issue, and clearly. Remember Aldous Huxley’s
there is danger near. The tension between personal lib- Brave New World ? It was, first of all, a world of caste.
erty and social justice is a necessary one, and should All the rest—the meaningless drug-optimized sex, the
not be collapsed into uncritical support for individual soma, the feelies, even the bottled babies—was sec-
(or corporate!) rights. Commitments to solidarity and ondary, just more bricks in the wall.
fairness must not be allowed to wither and die. The The emerging human genetic and reproductive
right to terminate an unwanted pregnancy is very dif- technologies are a turning point. Unless we harness
ferent than the “right” to modify the genetic makeup our moral intelligence and political will to shape them,
of future children. Biomedical researchers and fertility they will conform to the existing social divides and to
doctors have no “right” to develop species-altering the inadequacies of our democracy, and they will exac-
technologies in their petri dishes. And despite the erbate both. Until the designer babies and “post-
eagerness of venture capitalists and the willingness of humans” begin to populate the planet, until we allow
the patent office, they certainly have no “right” to inequality to be inscribed in the human genome, we’re
send them out into the world. all in this together.

Frank Moore, Digital Divide, 2000, gouache, oil and mixed media on paper, 19 1/2 x 24 1/4" (49.5 x 61.6 cm), SW 01127.
Courtesy of the estate of the artist and Sperone Westwater, New York.

THE ART OF FRANK MOORE human activities, but also ennobled by the higher motivations
“The human genome project, cloning, stem-cell research are that accompany human enterprise.” Moore lived with the HIV
all amazing and exciting—and fraught with danger,” said virus for nearly two decades, and was acutely aware that his
painter, AIDS activist, and naturalist Frank Moore in an life depended on scientifically engineered medications. And yet
interview only weeks before his death in April 2002. “They are many of his works explicitly confront the threats posed by new
marred by the same negative motivations that often plague technologies, including genetic engineering.

36 WORLD•WATCH July/August 2002


Brian Halweil

The War of
Words and Images
Some of civilization’s most powerful art has sprung
from humanity’s most anguishing crises, and the pending crisis
of human genetic modification is no exception.

I
nvestment analysts are raving about a company on humans conform to their stressful 9-to-5 lives?
the verge of going public. This firm (whose name “Art can be seen as a social laboratory,” says
cannot yet be released) plans to help other compa- Eduardo Kac, a Brazilian-born artist whose work was
nies improve the ability of their employees to work shown in the exhibit. One installation, for example,
long hours, help employees better conform physi- suggested what a made-to-order baby company might
cally and mentally to their workstations, and even look like. Another offered brochures for Gene Genies
reduce the desire of employees to go home and spend Worldwide, a company which, as the artists envisioned
time with their families. The firm draws its inspiration it, planned to harvest and collect the genes of the
from Fredrick Taylor, a contemporary of Henry Ford, world’s most creative individuals—the likes of physicist
whose principles of “scientific management” helped Stephen Hawking, architect I.M. Pei, author Michael
justify the modern assembly line as a way to maximize Crichton. As I studied this piece while looking over
the efficiency of the workforce. the shoulders of an elderly couple, the husband turned
The firm’s humble slogan is “We think of things to his wife and whispered in a strong Brooklyn accent,
that Mother Nature never could.” Interest in the com- “It’s just like Hitler.”
pany’s ser vices has intensified since the recent It was unlikely, of course, that the couple had
announcement of several other of the company’s gained whatever they knew about biotechnology from
planned projects: engineering people who have irre- reading scientific papers or having discussions with
sistible cravings for certain food products, and people experts. If they were like most people, they’d gotten
who are strongly attracted to the corridors of malls. most of their information about the subject from mass
If you find this company’s plans disturbing, you entertainment. For at least the past several years,
might draw some reassurance from the fact that the movies, TV shows, novels, and other forms of popu-
company does not yet exist, except in the minds of an lar culture had been integrating biotech themes into
anonymous collaborative of guerrilla artists who go by their stories with growing frequency. For millions,
the name ®™Ark. Several years ago, the group pro- such once-fantastic phenomena as cyborgs, clones,
duced a 30-minute promotional Microsoft powerpoint bionic powers, and biowarfare have become as famil-
presentation of their fictitious firm—complete with iar as popcorn.
multi-color graphics of projected profits—as part of “Dark Angel,” for example, is a current TV action
“Paradise Now,” a collection of artists’ renditions of drama featuring a transgenic, crime-fighting heroine
the biotech future which first opened two years ago at
Exit Art in SoHo, New York.
The ®™Ark presentation left me wondering: are Brian Halweil is a research associate at the Worldwatch
there any laws preventing such a company—once its Institute, where he studies the ecological and social impacts of
product is technically viable—from going right into biotechnology. His writing has appeared in The Christian
business? If this kind of engineering has already Science Monitor, The New York Times, The Los Angeles
become routine to help farm animals conform to the Times, The International Herald Tribune, Orion, and World
harsh conditions of a feedlot (it has), why not help Watch, and he was coauthor of State of the World 2002.

WORLD•WATCH July/August 2002 37


the risks of the rush

named Max. It takes place in


“a time not so far from now”
in a Blade Runner-esque
United States rocked by “ter-
rorist attack.” Max, an
escapee from a secret govern-
ment lab that makes geneti-
cally engineered soldiers, is
continually pursued by her
creators, who are in turn pre-
occupied with keeping quiet
government efforts to grow
souped-up soldiers in test
tubes.
The show’s writers and
producers don’t attempt to
address serious ethical issues
associated with genetically
engineered humans, such as
would be posed by the capa-
bility of biotechnology to transform the way we fight remains of the family dog to “RePet Inc.” and have it
wars. (The Sunshine Project, an international organi- cloned before his young daughter gets home from
zation exploring the dangers of new types of warfare school and is heartbroken. Just a few months after the
stemming from advances in biotechnology, documents movie came out, scientists at Texas A&M University
just a few of the potential biotech applications already announced that they had cloned the world’s first cat,
being considered by First World militaries, including a calico named “CC,” as part of “Operation Copycat.”
enhancing the abilities of soldiers to withstand sleep The effort was funded by Genetic Savings and Clone,
deprivation, thirst, hunger, and other forms of stress; a company set up to clone beloved pets and to rescue
using sophisticated neuro-pharmacology to develop endangered species.
“calmatives” and “malodorants” for use in crowd con- As the boundaries between science and science fic-
trol or to incapacitate enemy forces; and developing tion become ever more blurred, we may tend to react
novel bioweapons.) to new developments in technology with the same
Millions of people, we can presume, have gotten bemused detachment with which we habitually regard
their first exposure to the concept of genetically engi- science fiction. In fact, our vigilance may be all the
neered people through this show. Jessica Alba, who more diminished by the fact that the advances of real
plays Max, was named one of the “25 Hottest Stars science rarely come with the same dramatic tensions
Under 25” by Teen People, and the show is attracting and visual effects we’re accustomed to in our enter-
teen audiences around the world. Before long, any tainment. As a society, we run the risk of beginning to
ethical quandaries raised by the prospect of transgen- accept the new technologies as our new reality even
ics like Max may be moot. Transgenics will simply be before they hit the market—a desensitization that could
“cool.” (“Cool” was one of the common refrains— torpedo any public debate on these technologies.
along with “gross,” “yuck,” “scary,” and “no way!”— But widespread public involvement in making
I heard from my fellow spectators as I navigated the decisions about how to use technology is alien to
corridors of “Paradise Now.”) much of the world. “In the United States, the nation
It would be unrealistic to expect popular culture to driving innovations in biotech, technological pathways
offer serious criticism of something as momentous and are [often] decided solely by industry,” explains Dick
complex as the biological alterations of humans—yet Sclove, founder of the Loka Institute, which studies
the premises featured in sit-coms and movie dramas how societies choose technologies. “At best, things are
are easily interpreted as reality. As the gap between sci- decided by the balance of power of industry and other
ence fiction and fact narrows, we are caught up in a major interest groups, none of whom are likely to dis-
whirlwind of new discovery that obscures many of the cuss the hard cultural, economic, and political issues.”
implications of the new genetic technologies. Only a The most democratic method of making public
year ago, for example, a new movie called “The Sixth decisions about technology, says Sclove, may be that of
Day” featured Arnold Schwarzenneger as a distraught the Danish Consensus Conference. A typical Confer-
pet owner struggling to decide whether to take the ence is called when the Danish government is about to

38 WORLD•WATCH July/August 2002


words and images

Frank Moore, Release, 1999, oil on canvas over wood panel, 22 5/8 x 95" (57.5 x 241.3 cm), SW 99280. Private Collection. Courtesy Sperone Westwater, New York.

debate a technological issue that might have substan- In most nations, there is little if any democratic dis-
tial public impact. The Conference usually consists of cussion of technology (see the editorial on page 2 of
15 ordinary citizens—excluding experts or represen- this issue), and whatever discussion does occur gener-
tatives of trade associations, scientists, or other inter- ally comes way too late, after the technology has
est groups—who are treated to expert testimony and already been developed, commercialized, and com-
briefings on the topic at hand. After the Conference, mitted to particular applications. Only when societies
members cross-examine experts and request any other choose to have such discussions early in the process,
information they deem necessary, then prepare a doc- when the technology is still plastic, can the uses of the
ument outlining what they see as the major issues to be technology be molded for social benefits. (The rela-
considered by society. The report is presented to the tionship between human genetic engineering and
Parliament and disseminated to the national public, democracy is more intimate still, since human genetic
with discussions often following at the local level. (In engineering has the potential to create genetic castes
recent years, the Danish have scored very high on and other forms of severe inequity which would
international surveys of public understanding of tech- undermine the foundations of a democracy.)
nology, technology policy, and support of national I left “Paradise Now” thinking that art could in
technology policy.) some ways be quite effective in catalyzing public
Because of the diversity in this process, and the debate—helping to draw a line between those uses of
absence of dominant special interests, the groups are biotech that would leave us with a better world and
less likely to make mistakes or to pursue elitist goals, those that would turn us into compliant servants of
and are more likely to serve a broad public’s interest. some corporate-run, techno-eugenic future. In con-
Sclove compares a study of the implications of the trast, the debate on the new human genetic technolo-
Human Genome Project conducted by the now gies has to date mostly consisted of a discussion among
defunct U.S. Office for Technology Assessment scientists on various technical points—whether some-
(OTA) in 1988 and a Danish Consensus Conference thing is possible or economically feasible.
on the same topic the following year. In its 200-page “Science has so dominated the discourse on
report, OTA wrote that that “the core issue” is how to genetic engineering that the public feels left out,”
divide up resources so that genome research is bal- according to Frank Moore, another artist featured in
anced against other kinds of biomedical and biological “Paradise Now,” whose paintings often contain hori-
research. A much shorter report from the Danish Con- zons, buildings, and other structures assembled from
ference recalled the eugenic programs of the 1930s DNA double-helices. “Artists can help ensure that just
and worried that “the possibility of diagnosing fetuses because the average person doesn’t have a biotech
earlier and earlier in pregnancy in order to find background, he doesn’t have to completely miss the
‘genetic defects’ creates the risk of an unacceptable biotech discussion.”
perception of man—a perception according to which
we aspire to be perfect.”

WORLD•WATCH July/August 2002 39


Bill McKibben
Why
Environmentalists
Should Be Concerned
Humans have dangerously destabilized the Earth’s ecological system.
If we now begin altering our evolved interdependence with nature,
we will only accelerate the destabilization.

I
t’s not as if environmentalists really need something Genome Project and co-discoverer of the double helix,
new to worry about. The planet’s temperature is set “If we could make better human beings by knowing
to rise four or five degrees—every glacial system is how to add genes, why shouldn’t we? What’s wrong
already in rapid retreat, and icebergs measured in with it?”
units of U.S. states (the size of Rhode Island!) are For environmentalists with a sense of history, such
calving off the Antarctic. Species disappear daily; acid words recall earlier promises of grand utopias: power
rain; and you know the whole damn litany. We could “too cheap to meter” from nuclear plants. What we
be forgiven for wanting to take a pass on human know about how human genetics works is dwarfed by
genetic engineering. what we don’t know—and experimenting on our own
And yet I think it may turn into the single greatest genetic heritage seems unwise to say the least. If his-
battle environmentalists have ever fought, the one for tory is any guide, the experiment will come with dubi-
which the Grand Canyon and the African elephants ous side effects, likely to be visited upon the weakest
and Amazon deforestation and Love Canal were and poorest parts of society. If internal combustion, a
preparing us. The real test. century later, yields global warming, then what does
Some of the reasons for thinking so are pragmatic. this crash course in scientific breeding promise? At the
Changing the human germline is an almost prepos- very least, the demand that we exploit this technology
terous override of the precautionary principle, the idea immediately seems suspect (except to the venture cap-
that if you don’t know something’s safe you shouldn’t italists who have made the investments). Which is not
do it. We have rushed with blinding speed through the to say the scientific progress need grind to a halt.
first phases of the biotechnological revolution—what There’s plenty of work to be done this side of tam-
was experimental a decade ago now grows in half the pering with the germline—almost everyone concedes,
corn and soybean fields on this continent. Now we for instance, that using gene therapy to help existing
seem bent on going just as fast with our plans to tweak human beings with existing problems makes perfect
the human genetic code that until now we have hailed sense.
as nature’s finest achievement—already teams are com- But where engineers and many environmentalists
peting to produce the first human clone, a precursor part company is precisely on this question of trying to
of genetic enhancement. The ideas come thick and “improve” the species. And they disagree, I think, in
fast, from visionaries who foresee improving the intel- large measure for emotional reasons as well as prag-
ligence of our offspring, or increasing their muscle matic ones. The human instinct that looks at a free-
mass, or bettering their character. In the words of flowing river and sees something that could be
James Watson, the first director of the Human dammed to make power (or money) collides with the
human instinct that values, deeply and sometimes at a
level almost beyond words, the very free-flowingness
Bill McKibben is a former staff writer for The New Yorker. of that water. The engineering impulse to tinker, bend,
His books include The End of Nature; The Age of Missing twist, patent, sell comes up against the environmental
Information; and Hope, Human and Wild. impulse to appreciate, preserve, protect, cherish. And

40 WORLD•WATCH July/August 2002


environmentalists

that impulse, on both sides,


extends to the human
genome as surely as it does
to the Colorado River, the
Arctic National Wildlife
Refuge, the grassland
savannas of Africa.
At first glance, a human
being seems an unlikely
candidate for wilderness
designation. We are shaped
by a thousand different
forces—in a consumer soci-
ety those forces grow ever
cleverer, often overriding
even the desperate attempts
of our parents to shape
who we are. And yet, so far,
there is something irre-
ducibly wild about each of
us, the result of that partic-
ular assortment of DNA
that we ended up with. Not
random—but not defined,
either. We are, as yet,
unprogrammed. Or, at
least, the programming is
weak enough (our friends,
our schools, our origins)
that we can, albeit at some
cost, override it. Or not.
That’s what life is often
about, that choice.
And if the improvers
have their way, then life will
be about something else:
about the cells of our bod-
ies expressing the particu-
lar combination of proteins
that someone believes will
produce a particular result.
And no change, not even
the climatic havoc we are
now wreaking on the
planet, will be as large
as that. If, as Thoreau
insisted, we are rich in
accordance with how much
we can afford to leave
alone, then this will be the
ultimate test of whether
we’re rich enough. For
conservationists, the final
frontier lies, literally, right
beneath our fingertips.
Frank Moore, The Green Fuse II (milkweed), 2000, oil on canvas over featherboard, 39 x 20" (99x50.8 cm), SW 00308. ✦
Collection of Gian Enzo Sperone, New York. Courtesy Sperone Westwater, New York.

WORLD•WATCH July/August 2002 41


the risks of the rush

Human Engineering
Timeline
1953 James Watson and Francis Crick determine replicates DNA sequences. This process of
the “double helix” structure of DNA. This gene amplification makes gene mapping and
discovery is a major breakthrough in the forensics easier and cheaper.
study of genetics and reinforces the idea that
an organism’s DNA is the primary and domi- 1990 Human Genome Project is begun by an inter-
nant determinant of its inherited traits. national consortium of scientists, with most
of the funding coming from the U.S.
1973 Stanley Cohen and Herbert Boyer create a National Institutes of Health and the
transgenic organism using recombinant DNA Wellcome Trust, a medical philanthropic
technology, which allows the manipulation organization based in London.
and transfer of pieces of DNA from one
species to another. 1996 A sheep named Dolly, the first mammal to be
cloned from adult cells, is born at Scotland’s
1976 The first genetic engineering/biotech Roslin Institute. Previously, cloning had only
company, Genentech, is founded by Boyer been carried out with embryo cells.
and Robert Swanson. It is the beginning of
the commercial use of genetic engineering 1998 Dr. James A. Thomson (University of
technology, an industry which by 2002 is Wisconsin) and colleagues are the first to iso-
generating revenues of $25 billion a year in late human embryonic stem cells, which have
the U.S. alone. Within two years scientists at the potential to develop into almost any type
Genentech splice the human gene for insulin of tissue. This inno-
production into E. coli bacteria, which then vation opens up
synthesize human insulin. the possibil-
ity of
1978 Louise Brown, the first “test-tube baby” (in
vitro baby) is born in England, demonstrating
the feasibility of growing embryos outside of
the womb. In vitro fertilization is done by
putting sperm and an egg together in a lab
dish, where chemicals facilitate fertilization,
and then implanting the embryo into a
woman’s uterus.

1980 U.S. Supreme Court rules that


genetically engineered
microorganisms can be
patented (Diamond v.
Chakrabarty), setting
a precedent for
patents on
lifeforms.
STEPS IN MENTAL DEVELOPMENT
1983 Kary Mullis From an article describing a “clearinghouse
devises the for mental defectives” established in 1913 by
Polymerase the New York Department of Public Charities.
Chain Reac- This sort of analysis often accompanied early
tion (PCR) efforts to improve the human gene pool, and
technique, still remains a part of the thinking behind
which rapidly some 21st-century genetic research.
✦ American Philosophical Society

42 WORLD•WATCH July/August 2002


timeline

harvesting stem cells for use in treating 2001 In February, scientists at Celera Genomics
human diseases. and at the Human Genome Project report
that the number of human genes is probably
2000 In June, scientists at both Celera Genomics about 30,000, only about twice as many as
(a private company formed in 1998) and the the number of genes in a fruit fly and far less
publicly funded Human Genome Project than the long-standing textbook estimate of
announce that they have completed a draft of 100,000.
the human genome. The announcement
evokes hopes about medical advancements 2002 As reports circulate that some scientists may
based on understanding of the genome, as have already begun to implant cloned
well as controversy about the issue of public embryos in women, the U.N. begins work on
access to the information. a global ban on cloning.
—compiled by Vanessa Larson

E NDNOTES
Making Well People “Better” (pages 13-15) 5 Commission of the European Communities, European
Pat Mooney File. Tomorrow’s Bio-Society. (Brussels: EC Technology
Forecasting Office, 1980).
1 David T. Courtwright, Forces of Habit: Drugs and the 6 Time, January 11, 1999, “Special Issue: The Future of
Making of the Modern World (Cambridge: Harvard Medicine: The Biotech Century.”
University Press, 2001), 86. 7 Rogers and de Bousingen, 17.
2 Courtwright, 105.
3 Courtwright, 89. The Genome as a Commons (pages 33-36)
4 United Nations Development Program, Human Devel- Tom Athanasiou and Marcy Darnovsky
opment Report 2001 – Making New Technologies Work for
Human Development (New York and Oxford: 1 See, for example, Gregory Stock and John Campbell,
UNDP/Oxford University Press, 2001), 13. eds. Engineering the Human Germline: An Exploration
5 UNDP, 3. of the Science and Ethics of Altering the Genes We Pass to
6
Our Children (New York: Oxford University Press,
Pat Roy Mooney, “The Parts of Life – Agricultural Bio-
2000).
diversity, Indigenous Knowledge and the Role of the
2 Lee M. Silver, Remaking Eden: Cloning and Beyond in a
Third System,” Development Dialogue: A Journal of
International Development Cooperation, 1996: 1-2: 82. Brave New World (New York: Avon Books, 1997),
7
4,6,7.
Karla Harby, et al. “Beta Blockers and Performance
3 John A. Robertson, Children of Choice: Freedom and the
Anxiety in Musicians.” A Report by the beta blocker
study committee of FLUTE, March 17, 1997. New Reproductive Technologies (Princeton: Princeton
8
University Press, 1994), 166.
Deborah L. Stull, “Better Mouse Memory Comes at a
4 Silver, 11.
Price,” The Scientist 15(7), April 2, 2001, 21.
9 5 Silver, “Reprogenetics: How Do a Scientist’s Own
Sarah Lueck, “U.S. Says 16 Million Have ‘Pre-Diabetes’,”
Wall Street Journal, March 28, 2002, B8. Ethical Deliberations Enter into the Process?” Humans
and Genetic Engineering in the New Millennium
(Copenhagen: Danish Council of Ethics, 2000),
The New Eugenics (pages 21-23)
http://www.etiskraad.dk/publikationer/genethics/ren.
Michael Dorsey
htm.
1 6 Stock and Campbell, 86. See also http://research.med-
A. Rogers and D. de Bousingen, Bioethics in Europe
(Strasbourg: Council of Europe Press, 1995), 17. See net.ucla.edu/pmts/Germline/panel.htm.
also D. Kevles, In the Name of Eugenics (Cambridge: 7 Chris Mooney, “Idea Log: Oh no! Bill McKibben’s said
Cambridge University Press, 1995). too much. He’s said it all.” The American Prospect
2 Francis Galton, Inquiries Into Human Faculty and Its Online, March 28, 2002, http://www.prospect.org/
Development (London: Macmillan, 1883), 25. webfeatures/2002/03/mooney-c-03-28.html.
3
See also Bill McKibben, “Unlikely Allies Against
———, Memories of My Life (London: Melhuen
Cloning,” The New York Times, March 27, 2002
Publishers, 1908), 10.
http://www.nytimes.com/2002/03/27/opinion/27
4 G. Wolstenholme, (ed.) Man and His Future (Boston: MCKI.html.
Little Brown, 1963).

WORLD•WATCH July/August 2002 43

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