This watermark does not appear in the registered version - http://www.clicktoconvert.

com

CURRICULUM VITAE

SHAIK AZEEZA

Senior Research Fellow

Chemical Biology Laboratory
Division of Organic Chemistry – I
Indian Institute of Chemical Technology
Tarnaka, Hyderabad-500 607, INDIA
Phone: +91-40-27160123 Ext. 1633
Mobile: +91-9849857942
Fax: +91-40-27193189
Email: aazshaik@gmail.com, aaz_shaik@yahoo.com

OBJECTIVE
To pursue Postdoctoral position in the area of synthetic organic and medicinal chemistry
such as multidisciplinary drug discovery, drugs based on molecular mechanism,
prodrugs, selective cancer chemotherapy.

EDUCATIONAL BACKGROUND
Ø Ph. D., (Organic/Medicinal Chemistry)
Indian Institute of Chemical Technology (IICT), Hyderabad, India. (2004 till to
date)
Research work towards the “Design and synthesis of new molecules based on
thiolactomycin as potential antitubercular, antimalarial agents and new synthetic
approaches for the precursors of biologically active compounds” (Thesis has been
submitted to Acharya Nagarjuna University, Guntur, India)

Research Supervisor: Dr. Ahmed Kamal, Director Grade Scientist, IICT,

Hyderabad, India
Ø M. Sc., (Organic Chemistry)
Andhra University, Visakhapatnam, India (2003, First Division)
Ø B. Sc., (Chemistry, Physics, Maths)
Acharya Nagarjuna University, Guntur, India (2001, First Division)
Ø Intermediate (Chemistry, Physics, Maths) Board of Intermediate, Hyderabad,
India (1998, First Division)
This watermark does not appear in the registered version - http://www.clicktoconvert.com

PERSONAL PROFILE
Ø Male, Indian, born on July 24th, 1981

RESEARCH EXPERIENCE
Four plus years of research training under the guidance of Dr. Ahmed Kamal, an
eminent scientist in the Division of Organic Chemistry at IICT, Hyderabad, India.
Ø Based on SAR studies of thiolactomycin, Design and synthesized more than 30
novel quinolino substituted analogues of thiolactomycin as potential
antitubercular agents
Ø Keeping pace on Drug Resistance (MDR and XDR TB) synthesized a library of
sulfonamide linked analogues of thiolactomycin active against tuberculosis and
malaria
Ø Synthesized the dimers and conjugates of thiolactone and evaluated against
different strains of Plasmodium falciparum.
Ø Synthesized both enantiomers (3S,4R) and (3R,4S) of 3-methoxy-4-
methylaminopyrrolidine a key intermediate for a new quinolone antitumor
compound AG-7352, which claiming as a drug candidature.
Ø Synthesized both the enantiomers of (3R,4R) and (3S,4S)dihydroxy pyrrolodine
by catalytic and biocatalytic approach which are useful intermediates for the
preparation of biologically active Sialyl Lewis X mimetics and novel
carbohydrate mimics.
Ø Developed new approaches towards the synthesis of biologically active
compounds.
Ø Synthesized many pharmaceutically important compounds like fluoxetine,
duloxetine curcumene and curcuphenol with high enantioselectivity.
Ø Lipase mediated resolution of a key intermediate of thiolactomycin has been
developed and configuration was also assigned.
This watermark does not appear in the registered version - http://www.clicktoconvert.com

PROJECTS HANDLED
Ø Involved as a key member in the completion of three year collaborative research
project between IICT (INDIA) and University of Capetown (South Africa) under
Department of Science and Technology Programmed for the “Biocatalytic and
combinatorial approaches to novel product based antimalarial and antitubercular
agents” (Year 2004-2007).
AWARDS AND HONORS
Ø Qualified Council of Scientific and Industrial Research (CSIR) examination at the
national level for Junior Research Fellowships (Dec. 2003).
Ø Qualified Council of Scientific and Industrial Research (CSIR) a Senior Research
Fellowship (Aug. 2006).
PROFESSIONAL AND PERSONAL STRENGTHS
Ø Synthesis of library of compounds based on SAR studies
Ø Synthesis of biologically active natural and synthetic products
Ø Design of new drugs based on modification of the drugs that are being known
Ø Study of structure activity relation ship of a new compound
Ø Familiar with mechanism of action of known drugs
Ø Familiar with pharmacology
Ø Acquaintance with biological properties of known and recent drugs
Ø Acquaintance with process of biological evaluation
Ø Development of new and safe methods for the synthesis of pharmaceutically
important compounds
Ø Acquaintance with most of experimental techniques and safe hands on
instruments like HPLC and GC
Ø Interpretation of the structures using 1 H NMR, 13 C NMR, IR, and various mass
spectrometric data
Ø Capable of both collaborative and independent research
Ø Maintain good interpersonal relationships and excellent communication skills
Ø Knowledge of computers: MS office, Database management packages,
Chemoffice, preparation of research reports, review articles, manuscripts for
publications.
This watermark does not appear in the registered version - http://www.clicktoconvert.com

PRESENTATION AT SYMPOSIA
Ø International symposium on “Advanced in organic chemistry”, January 2-6, 2006
Kottayam, India
Ø International symposium on “green/sustainable chemistry”, January 9-15, 2006,
at New Delhi, India
Ø National conference on “National symposium on current trends in chemistry”
January 30-31, 2007, at Kalyani, West Bengal, India

LIST OF PUBLICATIONS

1. Publications in Medicinal Chemistry

1. A combinatorial approach for the synthesis of new molecules based on
thiolactomycin active against tuberculosis and malaria
Ahmed Kamal, Shaik Azeeza, M. Shaheer Malik, Ahmad Ali Shaik
Commucnicated 2008 (J. Comb. Chem.)
2. Synthesis and biological evaluation of thiolactone based analogues as potential
antimalarial agents
Ahmed Kamal, Shaik Azeeza, M. Shaheer Malik, Ahmad Ali Shaik
Communicated 2008 to (Eur. J. Med. Chem.)
3. Efforts towards the development of new antitubercular agents: Potential for
thiolactomycin based compounds
Ahmed Kamal, Shaik Azeeza, M. Shaheer Malik, Ahmad Ali Shaik and
Maddamsetty. V. Rao
J. Pharm. Pharmaceut. Sci. 2008, 11, 56s-80s.
Dedicated in memory of Ronald G. Micetisch
This watermark does not appear in the registered version - http://www.clicktoconvert.com

2. Publications in Organic Chemistry

1. Enantioselective synthesis of (3R,4R)- and (3S,4S)-dihydroxy pyrrolidine by
catalytic and biocatalytic approach
Ahmed Kamal, Shaik Azeeza, M. Shaheer Malik, Ahmad Ali Shaik and Shaikh
Faazil S. Rahim
Communicated to (Tetrahedron: Asymmetry)
2. Lipase mediated resolution of γ-azidoalcohols in aqueous and organic media:
Synthesis of (R)-and (S)- fluoxetine and duloxetine
Ahmed Kamal, M. Shaheer Malik, Ahmad Ali Shaik and Shaik Azeeza
J. Mol. Cat. B: Enzyme (Accepted)
3. Synthesis of enantiomerically pure γ-azidoalcohols by lipase-catalyzed
transesterification
Ahmed Kamal, M. Shaheer Malik, Ahmad Ali Shaik and Shaik Azeeza
Tetrahedron: Asymmetry 2008, 19, 1078-1083.
4. Enantioselective synthesis of (R)- and (S)-curcumene and curcuphenol: an
efficient chemoenzymatic route
Ahmed Kamal, M. Shaheer Malik, Ahmad Ali Shaik and Shaik Azeeza
Tetrahedron: Asymmetry 2007, 18, 2547-2553.
5. Chemoenzymatic synthesis of (3R,4S)- and (3S,4R)-3-methoxy-4-
methylaminopyrrolidine
Ahmed Kamal, Ahmad Ali Shaik, Mahendra Sandbhor, M. Shaheer Malik and
Shaik Azeeza
Tetrahedron: Asymmetry 2006, 17, 2876-2883.
6. Chemoenzymatic synthesis of (5S)- and (5R)-hydroxymethyl-3,5-dimethyl-4-
(methoxymethoxy)-5H-thiophen-2-one: a precursor of thiolactomycin and
determination of its absolute configuration
Ahmed Kamal, Ahmad Ali Shaik, Shaik Azeeza, M. Shaheer Malik and
Mahendra Sandbhor
Tetrahedron: Asymmetry 2006, 17, 2890-2895.
This watermark does not appear in the registered version - http://www.clicktoconvert.com

List of reviews
7. Approaches based on enzyme mediated kinetic to dynamic kinetic resolutions: A
versatile route for chiral intermediates
Ahmed Kamal, M. Ameruddin Azhar, Tadiparthi Krishnaji, M. Shaheer Malik
and Shaik Azeeza
Coord. Chem. Rev. 2008, 252, 569-592.

Book

1. Breadth and importance of acid-base catalysis in green chemistry

Ahmed Kamal, Shaik Azeeza, M. Shaheer Malik
A chapter for a handbook of green chemistry (Oxford university press).
Edited by Bill Nelson in 2008

REFERENCES

1. Dr. Ahmed Kamal,

Director Grade Scientist
Chemical Biology
Division of Organic Chemistry-I
Indian Institute of Chemical Technology
Hyderabad-500 607, A.P. INDIA
Phone: +91-40-27193157 (Off),
+91-40-23319370 (Res)
Fax: +91-40-27193189
E- mail: ahmedkamal@iict.res.in

2. Dr. M. Venkateswara Rao

Scientist
Division of Organic Chemistry-I
Indian Institute of Chemical Technology
Hyderabad-500 607, A.P. INDIA
Phone: +91-40-27160123 Extn 1635 (Off)
E- mail: mvrao@iict.res.in