Ruscogenin

PHYTOCHEMICAL

Introduction

Ruscogenin is an anti inflammatory phytochemical. Ruscogenin (RUS), first isolated from Ruscus aculeatus( Butchers Broom ), is also a major steroidal sapogenin of the traditional Chinese herb Radix Ophiopogon japonicus. The molecular formulae of ruscogenin are C27H42O4. Butchers Broom extract is the main source of ruscogenin. The increasing popularity of natural and herbal remedies in Europe in the 1970s reaffirmed its position in modern medicine. Novel uses for this plant have included its use as an anti-inflammatory agent and to prevent atherosclerosis. A variety of compounds have been isolated from butcher's broom. The 2 primary saponin compounds are ruscogenin and neoruscogenin. The ruscogenin content in underground and aboveground parts is approximately 0.12% and 0.08%, respectively.

Applications of Ruscogenin : 1. Edema of the legs. This herb is particularly useful for people who are on their feet for a long period of time in the course of a day. By drawing water out of cells and perhaps inhibiting electrolyte reabsorption in the kidney, butcher's broom helps to alleviate excess water retention in the feet and legs. 2. Leg discomfort. Butcher's broom contains compounds closely resembling steroids which help to reduce inflammation. 3. Peripheral vascular disease. By increasing circulation of the blood, butcher's broom may be of benefit in the treatment of disorders characterized by reduced circulation. Raynaud's disease & Buerger's disease are two such disorders. 4. Hemorrhoids. Butcher's broom is frequently combined with Witch Hazel as an ointment. When applied locally to the anus, butcher's broom may bring about tremendous relief from the pain of hemorrhoids. 5. Bronchial asthma. It has been reported that butcher's broom, when combined with black- or green-leaf tea, may improve inhalation and exhalation. 6. Varicose veins. Due to vasoconstriction and steroidal content, butcher's broom may help to alleviate the unpleasant symptoms of varicose veins. 7. Hypotension. Butcher's broom raises blood pressure and thus is a good treatment for individuals suffering from chronic hypotension.

Raw Material Source : Butcher's Butcher's broom (Ruscus aculeatus), a medicinal herb native to the Mediterranean and Europe is a member of the lily family. The plant has rigid, branched, and spiny leaflike stems which bear a greenish flower and red berries. Both the root and stem of the plant are used in herbal preparations.

Butchers broom has been reported to be effective in treating a variety of conditions including:

Chronic venous insufficiency Atherosclerosis Hemorrhoids Varicose veins

Common names
1. 2. 3. 4. 5.

Butcher's Broom Kneeholy, Knee Holly, Kneeholm Jew's Myrtle Sweet Broom Pettigree

Radix Ophiopogon japonicas , a traditional Chinese Herb also is an upcoming source of Ruscogenin. The tuberous roots are dug in summer. After the fibrous roots have been removed, the roots are dried in the sun. Typical Dosage Ointments and suppositories including butcher's broom are typically used for hemorrhoids. Encapsulated butcher's broom extracts, often combined with vitamin C or flavonoids, can be used for systemic venous insufficiency in the amount of 1,000 mg three times daily. Additionally, standardized extracts providing 50 - 100 mg of ruscogenins per day can be taken. Reported Side Effects No significant side effects have been found for butcher's broom. However, nausea and queasiness may result in rare cases. Butcher's broom is not recommended for those with high blood pressure. Indian Manufacturers of Ruscogenin : Pioneer Enterprise Mumbai ( www.pioneerherbal.com ) 2. Al Chem International - Haryana ( www.alcheminternational.com )
1.

Brands containing Ruscogenin : Brand Name Flebodolor Flebopom Ruscorectal Abrasone Rectal Origin Spedrog (Argentina) Typen (Argentina) Heumann (Germany) Seid (Spain) Content Ruscogenin Ruscogenin Ruscogenin Fluocinolone acetonide + hexetidine + ruscogenin Ruscogenin + vitamin A palmitate Trimebutine + ruscogenin Ruscogenin + trimebutine Ruscogenin + tetracaine hydrochloride Ruscogenin + tetracaine hydrochloride Aescin + esculoside + heparin sodium + ruscogenin

Calmoroide Ibuproct Proctolog Ruscoroid Ruskorex Venacol

Warner-lambert (France) Olvos (Greece) Pfizer (France, Singapore) Sanofi-aventis otc (Italy) Gsk (Poland) Llorens (Spain)

Pricing : http://www.nextag.com/ruscus-aculeatus/compare-html