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Mitochondria Cellular
Respiration Glycolysis Pyruvate Oxidation (Preparatory Reaction) Krebs Cycle Electron Transport System
MITOCHONDRIA
rod-shaped
vary
greately in both size (0.5 micrometers - 10 micrometers) and number (1 - over 1000) per cell of oxidative phosphorylation
site
provide
the chemical energy necessary to carry out the various cellular activities
DISCOVERY
Early
1850s - Rudolf Klliker, a German biologist describe the presence of what he called ordered array of particles in muscle cells.
- The term 'mitochondria (meaning thread-like granules) was coined by Carl Benda.
1898
1957
1984
STRUCTURE
contains
outer and inner membranes composed of phospholipid bilayers and proteins. Because of this double-membraned organization, there are five distinct compartments within the mitochondrion. They are:
the outer mitochondrial membrane, the intermembrane space (the space between the outer and inner membranes), the inner mitochondrial membrane, the cristae space (formed by infoldings of the inner membrane), and the matrix (space within the inner membrane).
Mitochondria
semi-autonomous in that they are only partially dependent on the cell to replicate and grow. They have their own DNA, ribosomes and can make their own proteins. Similar to bacteria, mitochondria have circular DNA and replicate by a reproductive process called fission.
Due
to the independence from the nuclear DNA and similarities with bacteria, it is believed that mitochondrion have originated from bacteria by endosymbiosis.
ENDOSYMBIOTIC HYPOTHESIS
Symbionts live together in a situation in which both benefit mitochondria have their own DNA and ribosomes
So, it could be that mitochondria are bacteria that invaded eukaryotic cells. Both would benefit
FUNCTION
production
of energy
Site
It
of cellular respiration
is important to maintain proper concentration of calcium ions within the various compartments of the cell. Mitochondria help the cells to achieve this goal by serving as storage tanks of calcium ions.
Mitochondria
helps in the building of certain parts of the blood, and hormones like testosterone and estrogen.
in the liver cells have enzymes that detoxify ammonia.
Mitochondria
Other
functions of the mitochondria include controlling the cell cycle - signaling, differentiation, growth and death - and assisting with cellular aerobic respiration.
CELLULAR RESPIRATION
CELLULAR RESPIRATION
enzymatic breakdown of glucose (C6H12O6) in the presence of oxygen (O2) to produce cellular energy (ATP)
Overall
1.
There are two types of cell respiration aerobic and anaerobic. Aerobic respiration occurs in the presence of oxygen.
Glycolysis
Oxidation of Pyruvate
Krebs
GLYCOLYSIS
Breaking
down glucose glyco lysis (splitting sugar) starting point for all cellular respiration in cytosol 10 steps inefficient generate only 2 ATP for every 1 glucose
GLYCOLYSIS
Glycolysis
can occur with or without oxygen. In the presence of oxygen, glycolysis is the first stage of cellular respiration. Without oxygen, glycolysis allows cells to make small amounts of ATP. This process is called fermentation. reaction (Aerobic): Glucose + 2 NAD+ + 2 Pi + 2 ADP 2 pyruvate + 2 NADH + 2 ATP + 2 H+ + 2 H2O+energy
Summary
FERMENTATION
TWO PHASES
Energy
PYRUVATE OXIDATION
Conversion Overall
reaction:
KREBS CYCLE
OXIDATIVE PHOSPHORYLATION
Krebs cycle produces NADH and FADH2 in the matrix, CO2 is generated in process of producing ATP. Protein complex in inner membrane removes electrons from NADH and FADH2 Protein complexes transport H+ ions from matrix to the intermembrane space. A pH and electrical gradient are created across the inner membrane by H+ into the intermembrane space. Channel Protein assist ATP synthase by allowing protons in intermembrane to flow back into matrix.
CHEMIOSMOSIS
Oxidation Phosphorylation
Krebs Cycle produce NADH and FADH2 Electrons are removed from NADH and FADH2 H+ ions are transported to intermembrane pH and electrical gradient are created ATP synthase generates ATP