Summary By Zachary Reiff

The article A clinical trial of efficacy and safety of inhalation sedation with a 50% nitrous oxide/oxygen premix (Kalinox) in general practice. The study itself was aimed at proving the safety and effectiveness of 50% nitrous oxide/oxygen premix by trained general practitioners (general dentists). Overall, the study included 549 patients with a recorded 638 sessions of the specific sedation. Furthermore, the study was conducted in the metropolitan area in France. Finally, the main reason to conduct the study was the fact that restrictions exist in France over the use of this treatment and more studies may provide enough evidence to advocate its safe use. The patients were chosen based on a few different criteria. Moreover, the following patients were included: patients with intellectual disability, children under the age of 5, adults or children with dental phobia and/or a marked gag reflex, and patients requiring support for a complex treatment. 33 dentists in the area of the patient base were chosen and all held postgraduate diplomas in conscious sedation. General practitioners reported successful treatment while using the 50% nitrous oxide/oxygen premix (Kalinox). Success was defined as performing dental treatment under inhalation sedation. Moreover, 93.7% of the 638 sessions were reported as successful. The 40 failed sessions were reported as such due to both sedation and treatment failure or treatment failure despite adequate sedation. The article breaks down into many other statistical findings. For example, the dentist would like to continue future treatments with the same patient under the 50% nitrous oxide/oxygen premix (Kalinox) sedation in 92% of the cases. While restrictions exist in France for 50% nitrous oxide/oxygen premix (Kalinox) in general practice use, the current research recorded an effectiveness of 93.7% success. This success rate is comparable to previous studies done in hospital settings. One potential issue that existed was that the 50% nitrous oxide/oxygen premix (Kalinox) caused minor adverse side effects like nausea and vomiting. Yet, the development of sedation for dental care supports the needs of public health. By allowing the safe use of 50% nitrous oxide/oxygen premix (Kalinox), the general public is able to get simple needs fulfilled by their general dentist instead of requiring hospital type care. Thus, the current article verifies the safety and effectiveness of the 50% nitrous oxide/oxygen premix for used by general dentist practitioners.