JORNADAL, MABELLENE G.

3DMT

AUTOIMMUNE DISEASES

SPECIFICITY

DISEASE
Hashimotos thyroiditis Graves disease Pernicious anemia cells Addisons disease Type I diabetes mellitus MG MS Autoimmune hemolytic anemia Idiopathic thrombocytopenic purpura Goodpastures syndrome RA Scleroderma SLE

TARGET TISSUE
Thyroid ThyroiD Gastric parietal Adrenal glands Pancreas Nerve-muscle synapses Myelin sheath of nerves Red blood cells Platelets Kidney, lungs Joints, lungs, skin Skin, gut, lungs, kidney Skin, joints, kidney, brain, heart, lungs

Organ-Specific

Systemic

OTHER AUTOIMMUNE DISEASES

DISEASE
Addisons disease Autoimmune hemolytic anemia Autoimmune thrombocytopenic purpura Crohns disease Disseminated encephalomyelitis Pernicious anemia Poststreptococcal glomerulonephritis Rheumatic fever Scleroderma Sjgrens syndrome

ORGAN OR TISSUE
Adrenal glands Red blood cells Platelets Intestines Central nervous system Stomach Kidney Heart Connective tissue Eyes, mouth

IMMUNOLOGIC MANIFESTATIONS
Antibody to adrenal cells Antibody to red blood cells Antiplatelet antibody Inflammatory infiltrate of T and B cells: mechanism unknown Sensitized T cells Parietal cell antibody, intrinsic factor antibody Streptococcal antibodies that cross-react with kidney tissue Streptococcal antibodies that cross-react with heart tissue Antinuclear antibodies: anti-Scl-70, anticentromere antibody Antinuclear antibodies, RA factor antisalivary duct antibodies, antilacrimal gland antibodies Activation of T lymphocytes

Sarcoidosis

Multisystem granulomas, pulmonary manifestations