Professional Documents
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Cardiovascular disease: leading cause of death in NA 44000 Canadians (40% under 65)/ year Campaigns educating about importance of organ donation + numbers of donors 4000+ of sickest patients in Canada/United States waiting list new heart. Some dont receive. Past few years demand for organs rise 15%/year (rate will increase). 3000- worldwide receive heart transplants/annually Dr. Michael Sefton (director Institute of Biomaterials and Biomedical Engineering at UofT): solution almost unlimited number of hearts for transplant: heart in a box: transplantable heart grown in lab 1) create scaffolding (biodegradable plastic) for cells to grow around 2) seed it with living cells 3) placed in bioreactor (incubator): maintains constant body temperature, gives nutrients + oxygen cell division 4) cells secrete proteins + growth factors = bind them together tissues 5) successful component of the heart
Blood always in blood tubes, vessels. In earthworms, squids, octopuses, vertebrates. Separates blood from interstitial fluid. E.g. Earthworm: 5 heartlike vessels: pump blood 3 major blood vessels. Blood larger blood vessels smaller vessels various tissues.
Platelets Description
destroy microbe) Antibodies are formed by some white blood cells invading microbes + toxins
Function
No nucleus, produced from large nucleated cells in bone marrow Small fragments of cytoplasm break from megakaryocyte (large cell in bone marrow) platelets Move through smooth blood vessels, rupture if they strike sharp edge (torn blood vessel) blood clotting reactions
Aneurysm
Arterioles
Blood vessels: blood away from heart Thick walls: outer + inner layers primarily connective tissue, middle layers muscle fibres and elastic connective tissue. Heart contracts: blood surges from heart arteries stretch (pulse = change in D). Heart relaxes: pressure drops, elastic fibres in wall recoil. Cells of artery have blood vessels for nourishment Birth defect, injury causes inner wall of artery to bulge. Weakened segment of artery protrudes as blood pulses through less support, eventually ruptures less oxygen + nutrients to tissues cell death. In brain Stroke. Smaller arteries elastic fibres and smooth muscle Autonomic Nervous System (part of nervous system, involuntary, controls motor nerves that maintain homeostasis): regulates D of arterioles Vasoconstriction: nerve impulse smooth muscles to contract reducing D
decreases blood flow. Vasodilation: relaxation dilation of arterioles increased blood flow cells in area energy-consuming tasks. Precapillary sphincter muscles regulate blood flow from arterioles to capillaries. E.g. Blushing: vasodilation of arterioles to skin capillaries. Pink = red blood cells close to surface. Releases excess heat produced nervous E.g. Paling: constriction of arteriolar muscles diverts blood from outer capillaries muscles = more oxygen, glucose for energy (danger or threat) Arterioles to capillaries open only if blood is needed. Majority of brain remains open, 1/50 in resting muscle open.