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Chapter 60:
The Autonomic Nervous System (ANS); The Adrenal Medulla
Sympathetic Distribution
Parasympathetic Distribution
QUESTIONS??
epinephrine raises the arterial pressure to a lesser extent but increases the cardiac output more Epinephrine has 5 to 10 times as great a metabolic effect as norepinephrine
Importance of adrenal medulla: 1. the dual mechanism of sympathetic stimulation provides a safety factor, one mechanism substituting for the other if it is missing. 2. to stimulate structures of the body that are not innervated by direct sympathetic fibers
Autonomic Reflexes
Cardiovascular Autonomic Reflexes Gastrointestinal Autonomic Reflexes Other Autonomic Reflexes
Sympathetic System Often Responds by Mass Discharge Parasympathetic System Usually Causes Specific Localized Responses.
prepares the body for vigorous activity need to deal with a life-threatening situation 1. Increased arterial pressure 2. Increased blood flow to active muscles concurrent with decreased blood flow to organs such as the gastrointestinal tract and the kidneys that are not needed for rapid motor activity 3. Increased rates of cellular metabolism throughout the body 4. Increased blood glucose concentration 5. Increased glycolysis in the liver and in muscle 6. Increased muscle strength 7. Increased mental activity 8. Increased rate of blood coagulation
some drugs act indirectly by increasing the release of norepi from its storage terminals
ephedrine, tyramine, and amphetamine
alpha blockers
phentolamine and phenoxybenzamine
beta blockers
beta1 and 2 - propranolol, beta1 - metoprolol
ganglionic blockers
hexamethonium
antimuscarinic drugs
atropine and scopolamine (muscarinic antagonist) blocks the effect of acetylcholine on effector cells