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AIMS
Antiphospholipid syndrome Pathophysiology diagnosis Treatment in pregnancy
APS/APLS/HUGHES SYNDROME
Autoimmune, hypercoagulable state caused by antibodies against cell-membrane phospholipids. Leads to thrombosis and pregnancy related complications such as miscarriage, stillbirth, preterm delivery and severe preeclampsia
BURDEN OF DISEASE
CMACH:
ANTIPHOSPHOLIPID SYNDROME
Thrombosis (venous, arterial, microcirculation) and/or Pregnancy morbidity
>3 consecutive miscarriage <10 weeks >1 fetal death > 10 weeks >1 preterm birth <34 weeks with normal fetal morphology due to pre-eclampsia or placental insufficiency
DIAGNOSIS
Research criteria for defining the antiphospholipid syndrome. Adapted from Miyakis et al (2006). With permission, John Wiley & Sons, Inc. 2006 International Society on Thrombosis and Haemostasis.
TYPES
Primary
Secondary
Associated with SLE or other autoimmune disorders Genetic marker: HLA-DR2/3, HLA-B8 Race: Blacks, hispanic, asians, native americans
CLINICAL FEATURES
Immune thrombocytopenia (ITP), haemolytic anaemia Cerebral: epilepsy, infarction, chorea, mirgraine, transverse myelitis Heart valve disease Systemic/pulmonary hypertension Livedo reticularis Amorosis fugax Leg ulcers
PATHOPHYSIOLOGY
DIAGNOSIS
TREATMENT
RECOMENDATIONS IN PREGNANCY