Project Phase I

A CMOS Diaphragm Based Label-Free DNA SoC Detection with Improved Sensitivity & Efficiency

Presented by: Shabaz Ahmed Sheikh.SS M Tech [Electronics], 2nd Year 12304013

Under The Guidance of Dr T Shanmuganantham Asst.Professor

Dept Of Electronics Engineering, Pondicherry University, Puducherry

Dept. of Electronics Engg. Pondicherry University

7/31/2013

Out Line
2

o Motivation

o Objective
o Existing Model o Problems In Existing Model o Proposed Model o Expected improvement in proposed model

o Work Plan
o References
Dept. of Electronics Engg. Pondicherry University

7/31/2013

Motivation
3

DEOXYRIBONUCLEIC acid (DNA) detection is an important analytical method in molecular biology, and it finds a wide range of applications from genetic disease diagnostics, medicine and drug discovery, to forensic investigation and food testing, etc. This way we can and will be able to diagnose and detect the fatal diseases like HEPATITIS, CANCER, TB hands on without any special technique required .
This if done on a large scale can bring down the cost of this Lab-On-Chip device

drastically and will be boon to the mankind.

Dept. of Electronics Engg.

Pondicherry University

7/31/2013

Objective
4

To design a CMOS Diaphragm Based Label-Free DNA SoC

Detection with Improved Sensitivity & Efficiency

Dept. of Electronics Engg.

Pondicherry University

7/31/2013

Existing Model
5

Dept. of Electronics Engg.

Pondicherry University

7/31/2013

Existing Model Contd

6

Dept. of Electronics Engg. Pondicherry University

7/31/2013

Problems In Existing Model

7

Resistance based .(piezoresistive)

Sensitivity can further be improved.

Interference due to unspecific binding. Communication/data rate to external wireless can be

improved. Power consumption can further be reduced.

Dept. of Electronics Engg.

Pondicherry University

7/31/2013

Proposed model
8

Capacitance based,i.e diaphragm will be used by iterating

different material combinations

Resistance to frequency

converter will be

replaced by

capacitive converter

QPSK system will be used instead of OOK for external

communication
Dept. of Electronics Engg. Pondicherry University

7/31/2013

Expected Improvements In Proposed Model

9

Better sensitivity and detection

Lower power consumption

Higher data rate

Dept. of Electronics Engg.

Pondicherry University

7/31/2013

Work Plan
Task
T1: Definition and plan

Subtask
Problem methodology plan

Duration
definition, July1-july25 10 and work

Expected Result
Study of A CMOS Membrane/Diaphragm Based Label-Free DNA SoC Detection Easy disease diagnosis eg. CANCER,HEPATITIS,TB, Avian Flu The methodology of design new capacitance or membrane based DNA detection Description about the tool to simulate the model The parameters and the values of input voltage used to simulate the model The expected result for proposed model Report submission for the work so far done Explanations for the queries regarding the work 7/31/2013 so far done

T2: Application

Identifying the applications July26-August10

T3: Proposal of A T3.1:Theoretical analysis August11- August 30 CMOS diaphragm based of existing model label-free DNA soc detection with improved sensitivity & efficiency T4.1: Choice of August 31- September 10 simulation tool T4.2: Simulation Sept 11- Oct 1 T4: Simulations conditions

T5: Presentations/ submissions

Dept. of Electronics Engg.

T4.3: Simulations of the Oct 02- Oct 15 proposed model. Oct 25 - Nov 25 T5.1: Report 1 Nov 9- Nov 30 T5.2: viva 1
Pondicherry University

References
11
[1] Y.-J. Huang, C.-T. Lin, L.-G. Chen, P.-Y. Hsiao, B.-R.Wu, H.-T. Hsueh, B.-J. Kuo, H.-H. Tsai, H.-H. Liao, Y.-Z. Juang, C.-K. Wang, and S.-S. Lu, A fully-integrated cantilever-based DNA detection SoC in a CMOS bio MEMS process, in Proc. IEEE Symp. VLSI Circuits, 2011, pp. 5051. C.-W. Huang, T.-H. Lin, [2] N. Gemma, S. Ouchi, H. Funaki, J. Okada, and S. Hongo, CMOS integrated DNA chip for quantitative DNA analysis, in Proc. IEEE Int. Solid-State Circuits Conf., Dig. Tech. Papers, 2006, pp. 560561. [3] S.-J. Kim and E. Yoon, Label-free CMOS biosensor with on-chip noise reduction scheme for realtime quantitative monitoring of biomolecules, IEEE Trans. Biomed. Circuits Syst., vol. 6, no. 3, pp. 189196, Jun. 2012. [4] N. Lajnef, S. Chakrabartty, N. Elvin, and A. Elvin, Piezo-powered floating gate injector for selfpowered fatigue monitoring in biomechanical implants, in Proc. IEEE Int. Symp. Circuits and Systems, 2007, pp. 8992. [5] N. Gemma, S. Ouchi, H. Funaki, J. Okada, and S. Hongo, CMOS integrated DNA chip for quantitative DNA analysis, in Proc. IEEE Int. Solid-State Circuits Conf., Dig. Tech. Papers, 2006, pp. 560561.

Dept. of Electronics Engg.

Pondicherry University

7/31/2013

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Dept. of Electronics Engg.

Pondicherry University

7/31/2013

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Dept. of Electronics Engg.

Pondicherry University

7/31/2013