Presented by -

Kiran Dhakane, I Sem. M. Pharm. Guided byMr. Kiran Bhusare, Dept.of Pharmacology, SBCOP, Aurangabad.
1

CONTENTS
Introduction

Manufacture techniques
Mechanism Usefulness Literature surveys Requirement

Marketed preparation

INTRODUCTION
Mouth Dissolving tablet are solid single unit dosage forms that

are placed in mouth , allowed to disperse or dissolve in saliva without need of water for frequently release of drug for quick onset of action.
Mouth dissolving tablet disappears rapidly before

swallowing.
Disintegrates in less than 3 minute.
Also called as fast dissolving tablet, orodispersible tablet, melt

in mouth tablet, repimelts tablet, porous tablet.

3

ADVANTAGES OVER THE CONVENTIONALDOSAGE FORM

Convenient for administration and compliant.
Good mouth feel can achieve. Rapid dissolution of drug and absorption which may

produce rapid, onset of action.

Ability to provide advantages of liquid medication in the form

of solid preparation.
Improved bioavailability by pregastric absorption.

IDEAL REQUIREMENT
On oral administration its dissolve/ disperse/

disintegrate in mouth in few seconds without necessitate of water.

Have a pleasing mouth feel. Have an acceptable taste masking property .

Be harder and less friable.

Have physical and environmental stability.
5

MANUFACTURE TECHNIQUES
Direct compression. Spray drying. Moulding. Lyophiliation. Sublimation. Mass extrusion.
Fig. Tablet compression machine

MECHANISM OF MOUTH DISSOLVIG TABLET

Swelling . Wicking . Deformation.

Particle Repulsive force.

USEFULNESS
For bed ridden and unco-operative patients For gediatric and pediatric patient For psychic patients No need of water to swallow the tablet ,which is highly

convenient feature for patients .

Who are traveling and do not have immediate access to water.
No risk of chocking or suffocation during oral administration.
8

LITERATURE SURAVEY
Deebjit Bhowmik et al / (2009) Fast dissolvin tablet : an

overview.
Ganesh Kumar et al / (2010) formuliion and evaluation of

fast dissolving tablet ofchlopromazine hcl

Shailendra Kumar Singh et al / (2010) fast disintegrating

combination tablets of omeprazole and domperidone.

Susijit Sahoo et al / ( 2010) Fast Dissolving Tablet: As A

Potential Drug Delivery System

9

REQUIREMENT FOR FORMULATION OF MOUTH DISSOLVIG TABLET

Sr. No. Requirement Tablet Compression Machine
UV -Visible Spectrophotometer Disintegration Test Apparatus Dissolution Test Apparatus Infra-red Spectrophotometer Hardness Tester Friability Test Apparatus

Availability Yes
Yes Yes Yes Yes Yes Yes
10

1
2 3 4 5 6 7

MARKETED PREPARTION
SR.NO PRODUCT NAME 1 2 3 4 5 6 7 8 Tab Almox 125 DT Tab Gudcef 100 Tab Vomikind MD 4 Tab Domoperi 5 DT Tab Dolonex DT Tab Nimos MD Tab Zifi 100 DT Tab Odoxil 125 DT CONTAIN Amoxyilline Cefodoxime Proxetil Ondansetron Domperidone Piroxicam D Nimusulide Cifixime Cefadoxil MFG.NAME Alkem Lifestar Mankind Ipca Pfizer Mankind FDC Lupine

9
10

Tab Disnee
Tab Pacimol XP

Nimusulide , Caffine
Paracetamol

Horizon
Ipca
11

REFERNCE
1)Ganesh kumar Gudas et al/ Journal of Pharmaceutical Science and Technology, Vol.2(1), 2010, 99-102 2)International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 1, Supple 1, Nov.-Dec. 2009

3)Asian Journal of Pharmaceutical and Clinical Research Vol.2 Issue 3, July-September 2009
5) Susijit Sahoo et al. / Drug Invention Today 2010,2(2),130-133

12

13