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The Increasing Incidence of Immune Regulatory Disorders
From Bach JF., (2002) 347:911920
POOR SANITATION, IMPURE FOOD
AND CROWDED LIVING CONDITIONS
Viral, bacterial
and protozoan Helminthic
infections infections
Regulatory T Cell
Excess
Conditioning
Immune reactivity
Inhibits
Crohn’s disease (Prevents) Excess
and other diseases Reactivity
GENETIC PREDISPOSITION
Helminths Modulate Immune
Responses in Rodents
• Self-limited colonization
• No multiplication in host
• No direct transmission
in
Active Ulcerative Colitis
Overall Response
CD8
CD25
TGFβ
IL10 TGFβ IL4, IL5
TGFβ IL10 IL13, IL10
Mostly CD4
Prevent/reverse inflammation
No contact required
Helminths TLR4
LPS
Regulatory
CD4 T cells CD4
IL12
IFNγ T Cell
Th1 Th1 / Th2 Proliferation
@
@
Effector
T cells
Judy Chinitz
New Star Nutritional Consulting
www.newstarnutrion.com
(914) 244-3646
Allan Goldblatt
Autism Associates of New York
www.autismny.com
(516) 921-3456