Professional Documents
Culture Documents
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Advantages of azithromycin over erythromycin does not include A. It can be safely administered in pregnancy B. It is not an enzyme inhibitor C. It is administered once a day D. It is acid stable
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Cholestatic jaundice is more common with A. Erythromycin base B. Erythromycin estolate C. Erythromycin ethylsuccinate D. Erythromycin stearate
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Vancomycin{Cell wall[-]}
Topical agents [Varied MOA] Mupirocin Fusidic acid Polymyxin B, Colistin, Bacitracin, Tyrothricin
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Ch
Exit
Peptidyl
Acceptor
AG
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Miscellaneous
1. LINCOSAMIDES: Clindamycin, lincomycin
2. STREPTOGRAMINS: Quinpristin+Dalfopristin
3. OXAZOLIDINONES: Linezolid, Radezolid, Torezolid 4. GLYCOPEPTIDESVancomycin, Teicoplanin, Ramoplanin
Topical
1. 2. 3. Mupirocin Fusidic acid Polymyxin B, Colistin, Bacitracin, Tyrothricin
Dr.U.P.Rathnakar
MD.DIH.PGDHM
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ADEs/DIs
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ADEs: Nerve deafness, nephrotoxic, red man syndrome [rapid i.v.- chills, fever, urticaria and intense flushing [Effect on mast cells-release histamine]
Uses-i.v Second choice drug to metronidazole for antibiotic associated pseudomembranous enterocolitis caused by C. difficile MRSA infections, enterococcal endocarditis with AG
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Teicoplanin-Newer glycopeptide-less toxic. MOA-similar to vancomycin No red man syndrome Effective against some VRE.
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Misc AMAs
Topically
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2. Colistin- G-ve only including pseudomonas 3. Bacitracin- bacterial cell wall synthesis 4. Tyrothricin- disrupt the integrity of the bacterial cell membrane
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infections (eg, impetigo) Prevention of wound infection following minor surgical procedures Prevention of wound infection in minor wounds/injuries/abrasions to the skin Treatment of secondarily infected eczematous dermatitis Care of the umbilical stump of newborns
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