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Definition
Allergic rhinitis (AR) = inflammation of the lining of the nose, characterized by one or more of the following nasal sx:
Nasal congestion Nasal pruritis Rhinorrhea Sneezing Nasal sx lasting > 1 hr on most days.
Ages affected
Not seen until after age 4 or 5.
(Takes approx 3 pollen season exposures).
10-15% in adolescents (adolescents and young adults). Peak age 30 (decades 2, 3 and 4).
Predisposition
Genetic:
Positive FHx (polygenic inheritance) Negative FHx does not rule out dx of AR
Atopic dermatitis:
Early sign of predisposition to allergy. 13% -/- parent, 30% +/- parent/sibling, 50% +/+ parent.
Nasal Polyposis
Allergic Rhinitis
Sinusitis
Asthma
Airway inflammation
Allergen Dendritic cell
IL-1 IgE MBP ECP LTs PGs PAF
Th0-cell B-cell
IL-4 IL-10 IL-13 Eotaxin IL-5 RANTES
Eosinophil
Mast cell
IFN-
Th1-cell
Th2-cell
Hours Secretion
Cytokines Chemokines
Immediate Rxn
Phenotype
ALLERGIC RHINITIS
Previous subdivision based on time of exposure: Perennial - indoor allergens (dust mites, molds, insects, animal danders) Seasonal - outdoor allergens ( pollens and molds ) Occupational
ALLERGIC RHINITIS
However.
Pollens and molds in some areas are perennial allergens Symptoms of perennial rhinitis may not be present the whole year Majority of patients are sensitized to many allergens and have symptoms throughout the year
ALLERGIC RHINITIS
New Subdivision in ARIA: based on duration intermittent persistent symptoms and quality of life parameters: mild moderate-severe
Abnormal sleep Impairment of daily activities sport, leisure Problems caused at work or school Troublesome symptoms
Positive rxn = over 3cm wheal with assd flare and pruritis (no rxn to neg control).
TCAs and some antipsychotics may also block skin test results.
Allergen avoidance Intermittent symptoms mild Not in preferred order Oral H1 blocker Intranasal H1 blocker And/or decongestant moderate severe Persistent symptoms mild moderate severe
Intranasal CS (300-400 ug daily) Not in preferred order Oral H1 blocker Intranasal H1 blocker review the patient And/or decongestant after 2-4 weeks (chromone) Intranasal CS (300-400 ug daily) improved failure (100-200 ug daily) review diagnosis step-down review compliance and continue query infections treatment in persistent rhinitis or other causes for 1 month review the patient after 2-4 weeks Blockage rhinorrhea increase Add intranasal CS add Decongestant dose ipatropium Or oral CS If failure: step-up Short term If improved; continue Itch/sneeze For 1 month Add H1 blocker failure Surgical referral
Allergen Avoidance
Avoidance of allergens
Allergen Avoidance
House dust mites
remove carpets use allergen-impermeable covers vacuum-clean beds damp-cleaning of furniture wash bedclothes with warm water
ANTIHISTAMINES
improvement due to restoration of filtration function of the nose dispels old belief that antihistamines have a negative effect on asthma
ANTIHISTAMINES
1st generation
sedation and anticholinergic effect
ANTIHISTAMINES
No satisfactory relief from nasal congestion Better results when taken routinely
NASAL ANTIHISTAMINES
decrease nasal congestion comparable with oral antihistamines but inferior to nasal steroids bitter taste not used < 5 years of age Azelastine and Levocabastine
ANTIHISTAMINES + DECONGESTANTS
Effective in decreasing nasal congestion Decongestants alone may cause insomnia, anorexia and nervousness at recommended doses reduced asthma symptoms, improved pulmonary function and benefited asthmaspecific quality of life
Storms WW et al : JACI 1989 Serra HA et al: Br J Clin Pharmacol 1998
Immunotherapy (ITX)
Should be considered if: pharmacotherapy insufficiently controls sx or produces undesirable side effects. appropriate avoidance measures fail to control sx. h/o AR for at least 2 seasons (seasonal) or 6 months (perennial). positive skin tests correlate with rhinitis sx.
Immunotherapy (cont.)
Contraindications: age < 5-6 yrs. use of beta-blockers. contraindication to epinephrine. pt non-compliance. autoimmune dz. induction during pregnancy (maintenance OK). uncontrolled asthma, FEV1<70%
Immunotherapy (cont.)
80-85% pts derive long-lasting symptomatic relief. After 3-5 seasons with adequate relief, stopping should be considered. ~60% pts will continue to derive symptomatic benefit with reduced need for medication. All pts on ITX should be encouraged to maintain environmental avoidance and may have to use concomitant medication (i.e.: antihistamines).
TERIMA KASIH