Professional Documents
Culture Documents
•As a result of endocrine signals that are poorly understood and in the
presence of a number of growth factors and cytokines the osteoclasts are
recruited and create a "resorption pit" where bone is digested (see Figure
1).
•Thereafter, the osteoclasts abandon the pit while osteoblasts settle within it
to deposit new bone. When resorption and deposition are coupled there is
no net change in the amount of bone present. Following menopause and
after some pathological processes the coupling is altered in favor of
increased resorption and as a result there is a loss in bone mass.
CLASSIFICATION OF OSTEOPOROSIS
PRIMARY
SECONDARY
Chronic Dx
Endocrine •Renal impairment
•Cushing’s syndrome
•Liver cirrhosis
•Hypogonadism
•Malabsorption
•Thyrotoxicosis
•Chronic inflammatory
•hyperparathyroidism
polyarthropaties
::Who is at RisK ??::
• Age. The older you are, the greater your risk of osteoporosis.
• Ethnicity. White and Asian women are at highest risk. Black and
Hispanic women have a lower risk.
• Calcium and vitamin D intake. A diet low in calcium and vitamin D makes
you more prone to bone loss. [In Malaysia most people hate drinking milk and
hence increase their probability towards osteoporosis]
• Too Much acidity in Food. As the blood must be a neutral pH, your body pulls
calcium from the bones to neutralize the acidity. This is often the major factor
in the development of osteoporosis
• Activity level. Lack of exercise or long-term bed rest can cause weak
bones.
• Smoking. Cigarettes are bad for bones, heart, and lungs.
• Drinking alcohol. Too much alcohol can cause bone loss and
broken bones.
• Lack of magnesium may be the cause of osteoporosis.
Calcitonin relies on magnesium to function properly. When we lack
magnesium, the balance between PTH and calcitonin tilts too far toward
PTH. This results in excessive stimulation of osteoclasts, which causes
net bone loss. Magnesium suppresses the hormone that tells your body to
pull calcium from the bones, and stimulates the hormone that tells the
body to put calcium in your bones.
::SyMPTOmpS::
Osteoporosis is called the
"silent disease“
because bone is lost with no signs. You
may not know that you have osteoporosis
until a strain, bump, or fall causes a bone
to break.
::DiagnosiS::
•Common clinical presentations
Increasing dorsal kyphosis (Dowager’s hump)
Low trauma fracture
Loss of height
Back pain
•Diagnosis
Primary osteoporosis is made after excluding secondary causes of bone loss
BMD measurement with dual energy x-ray absorptiometry (DEXA)
PREVENTION
1. Enough calcium intake daily; 800-1000 mg,
also other important nutrients; proteins, zinc, mg
& vitamin D for healthy and strong bone
Vitamin D is important in absorption of Ca
from food and incorporate it into bones
1 glass of high Ca milk = 500 mg Ca
Consider treating without measuring BMD Population appropriate for BMD testing
•Men & women w/ increase risk •All women >65 yo
+ a fragility fracture •Women aged 60-64 y,w/ increased
•Men & women taking chronic risk for osteoporotic fracture
systemic corticosteroids •Men at high risk
Hip osteoporosis
T-score< -2.5 T-score< -2.0
Normal BMD
T-score> -1
Treat w/ biophosphonate Spine osteoporosis only
T-score< -2.5 osteopenia
T-score of -1 to -2.5
Biophosphonate Workup for 2o osteoporosis
intolerant •PTH Treatmet options
•TSH •Biphosphonate
Treatment option •25-OH Vit D •Raloxifene
•CBC Monitor DXA every
•Parenteral biophosphonate •calcitonin
•Chemistry panel 1-5 yrs
•Teriparatide
•Raloxifene •Condition-specific tests
•Calcitonin
Treat underlying cause BONE HEALTH THERAPEUTIC ALGORITHM
if present PHARMACOTHERAPY HANDBOOK
MANAGEMENT OF OSTEOPOROSIS
Tibolone 2.5mg
• HRT do not prevent primary or secondary CVS disease and may even
increase events within the 1st years of use.
• C/I: undiagnosed vaginal bleeding, severe liver dx & a hx of VTE within
• the past 12 months
Selcetive Estrogen Receptor Modulators
(SERMs)
Raloxifene
• MOA: affects some of the same receptors that estrogen
does, but not all, and in some instances, it antagonizes
or blocks estrogen
Biphosphonates
Postmenopasal:
5mg OD or 35 mg
once weekly or one
Alendronate Etidronate 75 mg tablet taken
on 2 consecutive
Dosage: 400mg/day days once a month
Dosage: 5 mg daily for 2 weeks, followed
(prevetion); 10 mg by 13-week period Male: 35 mg once
daily,70mg weekly with no weekly
(treatment) etidronate,then
repeat cycle Glucocorticoid-
induced: 5 mg OD
Calcitonin
• a polypeptide hormone secreted by the parafollicular cells of the
thyroid gland in mammals and by the ultimobranchial gland of birds
and fish.
• According to NOF;
-Adults under age 50 need 1,000 mg of calcium and 400-800 IU of vitamin D daily.
-Adults 50 and over need 1,200 mg of calcium and 800-1,000 IU of vitamin D
daily.
• Alfacalcidol:
-rapidly converted to 1,25-dihydroxycholecalciferol in the liver→most
active form
dosage: Initial: 1 mcg/day. Maintenance: 0.25-1 mcg/day.
REFERENCES