Professional Documents
Culture Documents
1. Induction Phase
1a.Recognition of antigen ⇒ response initiation
1b.Development and amplification
2. Effector phase -------- eliminates invader
This is further subdivided into:
2a. Humoral Component (Antibody-mediated) B cells
2b. Cell-mediated Component T cells
Specific Immune Response
Specific Immune Response
Induction Phase
Interleukin-2 is a cytokine that has an autocrine function, that is, it causes the
proliferation of activated Helper T Cells which are now called Th0 cells.
The 2 subsets of T Cells are important because they are responsible for
providing the balance in response by the immune system.
Also any dysfunction at this level will lead to deficiencies in both Ab-mediated
and/or cell-mediated immunity.
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CD4
The central event in the generation of both
humoral and cell-mediated immune responses
is the activation and clonal expansion of TH
cells.
Activation of TC cells is generally similar to TH
cell activation.
TH cell activation is initiated by interaction of
the TCR-CD3 complex with a processed
antigenic peptide bound to a class II MHC
molecule on the surface of an antigen-
presenting cell.
The T cell Receptor
• Similar in structure to Immunoglobulins (similar to a single Fab
fragment.
• Composed of two glycoprotein chains (α /β or γ /δ ). Most
mature T cells have TCRs composed of an α chain and a β chain
(they are called α /β T cells).
• Each chain has a constant region and a variable region, similar to
an antibody light chain. Epitope-binding site
Transmembrane region
TCR compared to Immunoglobulins
Similarities
• Both have specific Antigen-binding region created by the variable regions of two
polypeptide chains.
• Both display great potential for diversity via genetic recombination at the
genome level
Differences
• A TCR is monovalent (has one binding site). An Ig is bivalent (has two binding
sites).
• The TCR has no secreted form. It is always membrane-bound.
• The TCR does not recognize free antigen. Antigen must be presented to a T cell
on an MHC molecule (next week).
• There is no class switching for the TCR. Once made, the TCR does not change.
Epitope-binding site
α chain β chain
Variable region
Constant region
Transmembrane region
ζ ζ
2
B7 is the ligand
CD28 is the receptor
B
YYY Th
Signal 2 - T cell help
APC Th ACTIVATION
Signal 2
Autocrine stimulation
(it makes a hormone that
is secreted and stimulate
the cell that made it
IL-2 used to be
called “T cell
growth factor”
Specific Immune Response
Effector Phase
Structure of Antibodies
Among B cells there are clones that express individual Ab’s to recognize
specific Ag’s.
Ab’s improve the host’s ability to recover from an invading Ag associated with
a virus or a bacterial toxin.
• Activate Complement
• Stimulate Ingestion of Bacteria
• Assist Cytotoxic Cell Function
• Stimulate Allergic Reactions
Specific Immune Response
Ab and Complement
Mast Cells and Basophils have receptors for IgE which can become attached
to the cell membrane.
When Ag reacts with this cell-fixed Ab it yields an enormous response with the
release of many inflammatory mediators.
Specific Immune Response
Effector Phase
Cell-Mediated Response
Lymphocytes involved are both:
Cytotoxic T Cells
In all other cases, Th1 cells activate macrophages to engulf, ingest and
digest the invading pathogen.
What happens next depends on whether Th1 or Th2 cells are stimulated.