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Properties
Enveloped, dsDNA Viruses
Replication in nucleus of host cell
Have a similar morphology (Icosahedral).
Causes primary and latent infection
Reactivation occurs during
immunosuppressive condition.
Classification
Alpha herpesvirus
Herpes simplex virus type 1 HSV-1
Herpes simplex virus type 2 HSV-2
Varicella-zoster virus VZV
Beta herpesvirus
cytomegalovirus CMV
Human herpesvirus type 6 HHV-6
Gamma herpesvirus
Epstein-Barr
virus EBV
Human herpesvirus type 8 HHV- 8
HERPES SIMPLEX VIRUS
Herpes simplex virus
HSV-1 infect the upper part of the body.
HSV-2 infect the lower part of the body -
genital infections
There is little cross protection.
HSV-1 and HSV-2 can be differentiated by
DNA sequencing and type specific antisera.
Herpes simplex virus
Transmission:
HSV-1 is transmitted primarily by saliva and
HSV-2 by sexual contact.
Vice versa can occur due abnormal sexual
practice.
Neonates can be infected during passing
through the infected birth canal.
Pathogenesis
Entry by skin or mucous membranes
vesicles latency
Transmission: Occurs
by kissing & exchange
of saliva.
Affects adolescents
and young adults
worldwide distribution.
EPSTEIN BARR VIRUS
EBV causes:
Infectious mononucleosis,
Burkits lymphoma,
Other B cell lymphoma,
Nasopharyngeal carcinoma &
Hairy leukoplakia in AIDS patients.
Symptoms
The classic triad of
mononucleosis is:
sore throat,
Fever
Lymphadenopathy
(usually in the neck, groin
or under the arms)
Symptoms
Other symptoms include:
Fatigue and malaise
Rash
Enlargement of the spleen
and liver
Hepatitis & encephalitis
can develop.
Symptoms
Hairy Leukoplakia
Oral Hairy Leukoplakia
Nonmalignant
hyperplastic lesion of
epithelial cells
Burkitts lymphoma