RABIES VIRUS

Whats this?


Morphology and structure
Replication
Pathogenesis
Clinical symptoms
Diagnosis
Prevention and Treatment

Morphology
bullet-shaped;
45-100 nm in diameter; 100-430 nm long.
structure

Core -ssRNA
L-protein (large protein)
---RNA dependent RNA polymerase RNP
Capsid N-protein
---protect RNA from hydrolysis
P-protein

Envelope
Bilipid layer
M-protein (matrix protein)
G-protein (glucoprotein)
---spike
---bind to the receptor of the host cell



Rabies is an RNA virus. The genome
encodes 5 proteins designated as N, P, M,
G, and L. The order and relative size of
the genes in the genome are shown in the
figure below. The arrangement of these
proteins and the RNA genome determine
the structure of the rabies virus.

Replication
Adsorption
Penetration
Uncoating
Biosynthesis
Assembly and release

biosynthesis
-ssRNA
RNA polymerase
+ssRNA

-ssRNA protein

virus
Pathogenesis
CNS

afferent fibers efferent fibers

nerve endings salivary gland
Neuromuscular organs and tissues
junction
muscles
Virus

Clinical symptoms
Early stage (1-3days)
fever(37.5-38)
vomit
wound:pain,red,itching
Exciting stage(1-3days)
fever(39-40)
hydrophobia:pharyngeal muscle cramp,dyspnea
dehydration
Paralytic stage(15-20hs)
nerve fiber paralysis
respiratory and circulatory failure
death

Diagnosis
Pathogenic history
Isolating the dog(7-10days)

cerebral smear or slice
immunofluorescent stain

Prevention and treatment

Kill wild dogs
Keep away from
dogs

Clean the wound
Passive immunity
vaccine



Contributers
Bian Shu
Cong Ping
Mu Xueru
Shao Cong
Zhang Jingjing
Zhu Wenying
Cheng Wei
Hu Chen
Li Yuntao
Li Daowei
Wang Shengxi