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Introduction
What is biosensor?
History
Types
Commercial Application
Conclusion
Biosensor is an analytical device, which converts a
biological response into electrical signal.
The term biosensor is often used to cover sensor devices
used in order to determine the conc. of substances and
other parameters of biological interest even where they
do not utilize a biological system directly
Biosensors are method of rapid, infield detection of
disease toxins such as pesticides and hazardous wastes.
They are becoming an increasingly popular analytical
tool among analytical chemist involved with
environment.
Current Definition for
Biosensors:
A sensor that integrates a biological element with a physiochemical
transducer to produce an electronic signal proportional to a single analyte
which is then conveyed to a detector.
www.imec.be/ovinter/static_research/BioHome.shtml
HISTORY
The father of biosensor is Prof. L.D. Clark.
Microorganism
Tissue
Cell
Organelle
Nucleic Acid
Enzyme
Enzyme Component
Receptor
Antibody
http://www.chemistry.wustl.edu/~edudev/LabTutorials/HIV/DrugStrategies.html
2ND Component: Physiochemical
Transducer
Acts as an interface, measuring the physical change that occurs with the reaction at
the bioreceptor then transforming that energy into measurable electrical output.
3RD Component: Detector
www.modernmike.com
Analyte Biological Signal Recorder
component transducer
What do they have in common?
Biosensor
Nose
Eye
Flow Cell
II
Flow Cell
Reference Sample
Pathogenic
Bacteria
Integrated optical interferometric sensor
Reference Sample
www4.tsl.uu.se/~Atlas/DCS/DCSIL/therm.html
ELECTROCHEMICAL BIOSENSORS
http://www.lsbu.ac.uk/biology/enztech/index.html
ON THE BASIS OF BIOLOGICAL ORGANISMS
BIOSENSOR ARE CLASSIFIED.
Bacterial biosensors.
Antibodies (Immunosensors)
Tissue
Enzymes
BACTERIAL BIOSENSORS
• Clinical diagnostics
• Food and agricultural processes
• Environmental (air, soil, and water) monitoring
• Detection of warfare agents.
www.fuji-keizai.com/e/report/biosensor2004_e.html
APPLICATIONS IN A REVIEW
http://www.must.edu.my/~ccyeo/topics/biosensor.jpg
REFERENCES
1. WWW.NANOWERK.COM/SPOTLIGHT
2. WWW.NCBI.NLM.NIH.GOY/PUBMED/15262314
3. WWW.WORLDFOODSCIENCE.ORG/CMS/PID
4. WWW.EMERSALDINSIGHT.COM
5. MAXWELL D., TAYLOR M.J., NIE S. SELF
ASSEMBLED NANOPARTICLE PROBES FOR
RECOGNITION AND DETECTION OF
BIOMOLECULES
6. WIKIPEDIA
7. SOLID STATE PHYSICS BY E. HALL, 2e