Immune Response

How does the mecanism

of foreign configuration can cause both
non specific and specific immune
response?
Complement
Complement is a group of protease in a serum
which complement serums activity in bacteria
or cell lysis

CRP (C-reactive Protein)
An acute phase protein; group of protein
which is increasing in blood when acute
infection happens
CRP as opsonin to actived classic pathway of
complement
Cytokine
Cytokine is group of peptide which is
produced by immunocompetent cell and plays
a role in reducing or increasing immune
system
Cellular Immune System
Phagocytes
NK Cell
Lymphocytes
Phagocytes
Cells which attract (using chemotaxis),
attached to, swallow, and digest foreign
materials
Include macrophage



NK Cell
NK cell is granular lymphocyte which can
recognize infected surface glycoprotein cell and
kill that cell.
Its circulating in the blood and lymph to lyse
cancer cells and virus-infected cells.
The number of NK cells around 5-5% of
lymphocyte in blood and 45% of lymphocyte in
tissues.
These cells have function in nonspecific immunity
against viruses and tumor cells.
Lymphocytes
Lymphocytes are cellular components of the
immune system that is specific to the antigen
through receptor structures on the surface of
immunocompetent cells.
Lymphocytes are divided into two, namely T
and B lymphocytes
Limfosit T
it differentiates from thymus gland
besides as immunocompetent cells, T
lymphocytes also play a role as a regulator in
the bone marrow, whether the body will
respond in humoral or cellular.
Limfosit B
It differentiates in Bursa Fabricius for aves and
in gut associated lymphoid tissue (GALT) for
other vertebrates.
B lymphocytes play a role in humoral immune
system therefore they will be able to
differentiate into plasma cells which can
generate specific antibodies.
Antibody/Immunoglobulin
group of glycoprotein which is produced by
plasma cells in response to certain foreign
configuration
It can bind to the antigen, complement, or
receptors on the surface of
immunocompetent cells
Antibody can increase the effectivity of
antigen elimination
How non specific immune
response become specific
immune response?
Nonspecific immunity acts as first line of
defense against infectious agent, which
pathogen will be destroyed before it
proliferates and causing infection.
If this defense doesnt work well, specific
immune system will be activated.
Healing through a specific immune response
will leave specific immunological memory so
that subsequent infection with the same
infectious agent will not cause disease
Respon Imun



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