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CHEMISTRY PROJECT

Drug: Antacid Effectiveness Analysis


To determine the neutralizing ability of antacids in
different brands using back titration
7C Candy Kwok (12)
Maggie Lam (13)
Cecilia Wu (23)

THEORY
ANTI ACID IS A KIND OF MEDICINE
THAT USED TO CURE STOMACH
ACHE
IN THIS EXPERIMENT ,WE WILL PUT
THE ANTI ACID IN KNOWN
MOLARITY (O.1M)HCl AND IS BACK
TITRATED AGAINST STANDARD
NaOH SOLUTION.

WE CAN DETERMINE THE


NEUTRALIZING POWER OF EACH
BRAND OF SAMPLE BY RECORDING
THE VOLUME OF NaOH USED IN
BACK TITRATION
THE ONE WHICH USE LESS NaOH IN
BACK TITRATION MEANS THAT IS
THE STRONGER

WEISEN-U

Composition
OUTER LAYER (yellowish green)

INNER CORE (white to yellowish white)

Biodiastase 200025mg

Methylmethionine Sulfonium
Chloride25mg

Dried Aluminum Hydroxide Gel192mg


Magnesium Hydroxide159mg

ACTAL
Composition
Al(OH)3 216 mg)

Unknown

Composition
Aluminium/ magnesium hydroxide
simethicone

Apparatus & reagents used


0.1M NaOH solution
0.1M HCl solution
3 tablets of antacids of different brands
Phenophthalein indicator
Pipettes and pipette fillers
100ml volumetric flasks
Electric balance

Apparatus & reagents used


Mortars and pestles
Hot plates
White tiles
Thermometer
Stop watch
Dropper
Conical flask

Distilled water in wash bottle


Tap water.
Burettes
Filter funnel
Labels
Glass rods
Stands and clamps
Beakers

Chemical reactions involved


Acid + Base Salt + Water
NaHCO3 + HCl NaCl + H2O + CO2
CaCO3 + 2HCl CaCl2 + H2O + CO2
Al(OH) 3 + 3HCl AlCl3 + 3H2O
Mg(OH) 2 + 2HCl MgCl2 + 2H2O
No. of moles = Molarity volume

Procedure

Procedure
Transfer an antacid tablet to a clean mortar
and crush it in to a fine powder
Weigh the mortar filled with fine powder
Transfer the powder to a conical flask

Weigh the mortar again


Dissolve the antacid with 150ml of distilled
water by using hot plate
Cool the dissolved antacid to room
temperature (25 ) by immersing it in tap
water

Transfer the dissolved antacid to a 250ml


volumetric flask.
Fill the flask to the mark with water.
Cap the flask and invert several times to
mix well.

Use a pipette to transfer 25ml of dilute HCl


solution to the conical flask that HCl is in
excess.
Add the dissolved antacid to the conical
flask
Swirl the flask until the liquid become
slightly cloudy.

Clean, rinse and fill a burette with NaOH


solution
Release a small amount of NaOH solution
to leave the tip entirely filled.
Record the initial NaOH volume reading
from the burette.
Place a white tile under the flask.

Add 3-4 drops of phenothalein to the flask.


Add NaOH solution from the burette with
continuous swirling until the colour of the
liquid change from colourless to pale pink.
Record the final NaOH volume reading
from the burette.
Repeat the experiment by using antacids in
different brands.

NO. OF MOLE OF HCl


NEUTRALIZED BY EACH SAMPLE
WEISEN U:(2.559/1000)mol
TAITAN:(2.12/1000)mol
HYDROSOIL:(1.24/1000)mol

Source of error
Some ingredients in the anti-acid may affect
the pH value of the mixture and the result.
Loss of active ingredient during
transferring.
The meniscus didnt sit at the graduated
mark of the burette or pipette.
The coatings of anti-acid may not dissolve
in acid or dissolve slowly.
The other ingredients may affect the
solubility of the bases inside the anti-acid

The reaction may not be complete.


Error in taking burette reading (0.05 cm3).
The end point may not equal to the
equivalence point.
The antacid was coloured and the solution
was cloudy and it was difficult to observe
the colour change and hence the end point
may be overshoot.
During the heating process, some of the
liquid may evaporate.

Improvements
Sufficient time should be given for the
reaction of acid and base.
pH metre should be used to detect the end
point.

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