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  • Acute Glomerulonephritis Pathophysio

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    shaider119
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    Post-streptococcal infection can lead to the formation of antigen-antibody complexes that become trapped in the glomeruli, causing inflammation and proliferation of endothelial cells. This increases permeability of the basement membrane and occlusion of glomerular capillaries, decreasing the glomerular filtration rate. The resulting retention of water and sodium leads to hypervolemia, hypertension, edema, and other symptoms.

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    The pathophysiological flow of acute glomerulonephritis in a 5-year old female.

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    Acute glomerulonephritis Pathophysio

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    Post-streptococcal infection can lead to the formation of antigen-antibody complexes that become trapped in the glomeruli, causing inflammation and proliferation of endothelial cells. This increases permeability of the basement membrane and occlusion of glomerular capillaries, decreasing the glomerular filtration rate. The resulting retention of water and sodium leads to hypervolemia, hypertension, edema, and other symptoms.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
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    1K views4 pages

    Acute Glomerulonephritis Pathophysio

    Uploaded by

    shaider119
    Post-streptococcal infection can lead to the formation of antigen-antibody complexes that become trapped in the glomeruli, causing inflammation and proliferation of endothelial cells. This increases permeability of the basement membrane and occlusion of glomerular capillaries, decreasing the glomerular filtration rate. The resulting retention of water and sodium leads to hypervolemia, hypertension, edema, and other symptoms.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 4

    Post-streptococcal infection

    (group A, beta-hemolytc)

    Release of material from


    the organism into the circulation
    (antigen)

    Formation of antibody

    Antigen-antibody complex
    trapped in the glomeruli

    Inflammatory response
    Proliferation of endothelial cells

    Increased permeability EDEMA


    of basement membrane

    Occlusion of the capillaries of glomeruli


    Vasospasm of afferent arterioles

    Decreased GFR

    Retention of water and sodium


    Hypervolemia HYPERTENSION
    Circulatory congestion
    protenuria

    Hypoalbuminemia

    Decreased COP

    Fluid loss to the interstitial space

    Edema

    back
    oliguria

    retention of water and sodium

    hypervolemia

    hypertension

    back

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