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NMR-basics
H-NMR
Cl
Cl
CH2CF2
A2X2
A2
H
Cl
Cl
Cl
Cl
A4
Enantiotopic Protons
Plane of symmetry
H
Cl
Me
COOH
A2X3
A2X
d =6.15
J = 53.6 Hz
6.0
2.5
2.0
1.5
1.0
AAXX
F
H1-F4
=> cis
3J
H2-F4
=> trans
The two protons are coupled to the same nuclei with different coupling!
Magnetic Non-Equivalence
Magnetic Equivalence
2-H
H-1 Cl
Cl
3-H
F
spin system?
These protons are chemically equivalent but are magnetically nonequivalent because they have different couplings with neighbors
JH1-H2
JH1-H4
HC
OH
Me
OH
COOH
ABX
HB
HA
H
CH3
HO
Me
H
Me
COOH
H
OH
COOH
H1-NMR
OH
OH
HC
7.0
CH3
CH2
HO
6.5
CH3
CH
2.70
2.60
4.20
1.20
4.0
3.5
3.0
2.5
2.0
1.5
Dissymmetric center
H
OH
COOH
HOOC
H H
H H
B1
B2
A1
A2
Plane of symmetry
Enantiotopic groups
Ha1 = Ha2
Hb1 = Hb2
Diastereotopic protons
A2B2X
AB
AB
X
AB
Me
HOOC
H
H
2 dissymmetric centers in
symmetrical molecule
Me
H
H
H
COOH
COOH Me
H
COOH
H
H
Me
Me
Symmetrical : s plane
Diastereotopic protons
Symmetrical : C2 axis
Enantiotopic protons
CH
CH2
HA
Mixture of 2 isomers
HB
HO
H2
HO
H1
Me2
H1
*
Me2
Cl
Me1
HO
Me1
Me2
H3 C
Cl
Cl
Cl
Cl
d H1 = d H2
d H1 d H2
d Me1 = d Me2
H1
H5
d Me1 d Me2
H2
CH3
d H1 d H2 AB
d H3 d H4 AB
Br
H6
CH3
H3
H4
d H3 = d H4 A2
2J
CH3
ABX3
H3C
3J
A-Me
AB
= 9.4 Hz
= 3JB-Me = 7.0 Hz
CH3
dq
3.60
4.5
d B = 3.55
d A = 3.40
3.50
4.0
3.5
3.40
3.0
2.5
2.0
1.5
COOH
AB
AB
H3 C
CH3
2 doublets
Magnetic Equivalence
H
A1
A2
B1
Enantiotopic protons:
B2
Ph
HA1 = HA2
HB1 = HB2
Diastereototopic protons:
HA1 HB1
HA2 HB2
Magnetic equivalence
JA1-B1 JA2-B1
A1 and A2 are
Magnetically different
AABB
AABB
AABB
Cl
N
A'
H
B
B'
AABB: para
AABB: Ortho
Pople Notation
A2X (if the shift difference of CH2 and CH is large
Y
CH2 HC
OR
compare to coupling).
OR
3 Spins
AABBC
JAX = Jcis = 10 Hz
JAM = Jtrans = 17 Hz
JMX = Jgem = 2 Hz
A : dd
Jtrans
Jcis
Virtual Coupling
Virtual coupling
First order
O2N
CH3
HO
CH3
Same shift
CH2-OH
CH3 broad
CH2b
Virtual
Coupling
Me broad doublet
COOH
H
Me
COOH
A2B2CX3
1)
2)
3)
Singlet
Virtual Coupling
3)
Ph
Br
H1
H
H2
Br
Ph
H1 = H 2
Enantiotopic protons
Magnetically non-equivalent
AAXX
Due to fast rotation, J is average
A2X2
H
H1
Br
Br
H2
Ph
1r, 3s; Meso
H1 = H2
diastereotopic protons
ABX2
COOH
H1
H1
H1
H1
OH
OH
H2
H2
H2
H2
OH
H
H3
H
H3
OH
H3
COOH
H3
COOH
H1 H1 diastereotopic
H1 H1 diastereotopic
H3 H3 diastereotopic
H3 H3 diastereotopic
Group1 = Group3
Group1 = Group3
H2 H2 diastereotopic
H2 = H2 enantiotopic
H A X HA X HA X HA
R HB R HB R HB R HB
Isotactic polymer
AB
H A R HA X HA R HA
Syndiotactic polymer
A = B A2
R HB X HB R HB X HB
CH3Cl d(calc)=2.76
d(exp.)=3.1
CH2Cl2 d(calc)=5.29
d(exp.)=5.3
CHCl3 d(calc)=7.82
d(exp.)=7.27
e.g. CH3-CO-CO-CH3
Subst. Effect
- C2-C3
=O (at C2)
=O (at C3)
-CR3 (at C3)
value
+0.244
+1.021
+0.004
-0.038
SSi(d)
+1.231
Calculating
Shifts for
olefinic
compounds
H1
OEt
+ 1.35 + (-1.28)
H1
H2
H2
7.0
6.5
6.0
5.5
5.0
4.5
4.0
3.5
3.0
2.5
2.0
1.5
1.0
CN
COOEt
Which one ??
COOEt
CN
Z isomer
Base
Ph (gem)
CN (cis)
COORconj *(trans)
effect
5.23
1.43
0.78
0.33
E isomer
Base
Ph (gem)
CN (trans)
COORconj * (cis)
effect
5.23
1.43
0.58
1.02
Total
7.77
Total
8.26
Calculating Shifts
for aromatic
compounds
CH3
8.00
7.90
7.80
7.70
7.60
7.50
7.40
CH3
CH3
NO 2
NO 2
t
J=1.8
dt
J=7.7, 1.5
ddd
J=8.1, 2.2, 1.1
8.5
8.0
t
J=8.1
CH3
CH3
NO 2
NO 2
td
J=7.4, 1.1
dd
J=8.1, 0.7
8.1
8.0
7.9
7.8
7.7
~td
J=8.1, 1.5
7.6
dd
J=7.7, 1.5
7.5
7.4
NO2
C5H9NO4
3H
CH3
CH3
CH
t
3H
CH2
O
q
2H
q
1H
5.5
5.0
4.5
4.0
3.5
3.0
2.5
2.0
1.5
1.0
C5H8O
CH3
CH2
CH
CHO
CHO, d
J=8.1 Hz
CH
t,
J=7.4
Trans J
ddt,
J=15.8, 8.1, 1.5
CH2
dt,
J=15.8, 6.9
1.20
6.15
7.0
2.45 2.40
1.10
2.35
6.9
1.00
1.16
6.10 6.05
1.15
0.93
2.45
3.73
C4H6O2
H
CH3
O
C
I = C H/2 + 1 = 2
s
H
O
Jcis = 6.6
2J
gem
dd
14.0, 6.6
7.3
dd
6.6, 1.5
dd
14.0, 1.5
Jtrans = 14.0
4.9
4.8
= 1.5
4.7
4.6
7.2
CH=
1.00
2.14
3.09
400 MHz
O
3, ddd
5.0, 1.5, 0.9
5, dd
9.2, 2.4
8.5
3, d(2.4)
5, ddd
7.9, 7.4, 1.6
5
4
3
6, dt
7.9, 1.0
8.0
8.5
8.0
4, ddd
7.4, 5.0 , 1.0
7.5
80 MHz
9.0
6, d
(9.2)
7.5
NEXT
Index
NMR-basics