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Genomic Mapping
A map - graphic representation that provides information
about the location of sites and the spacing between them.
Maps for the genome provide the relative order of items
(markers) along the chromosome.
Genomic Maps :
Genetic maps.
Physical maps.
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Low resolution
Physical Maps
http://www.waisman.wisc.edu/cytogenetics/procedures/FISH/FISHmethod.html
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clones
contig
(contiguous array)
contig
assembly
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Physical Maps
The ultimate physical
map is the
complete sequence
of a chromosome.
Hybrids are
formed.
http://www1.genetics.wisc.edu/466/fall99/lect13/sld011.htm
Markers:
+ (1) presence
- (0) absence
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RH Computational Task
http://www.cs.technion.ac.il/~benny/RHO.pdf
http://www.cs.technion.ac.il/~benny/RHO.pdf
RHO Output
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RHO Results
Chromosome 1 analysis:
There are 132 markers and 93 hybrids.
Results for the Maximum Likelihood estimation method:
Whitehead
Institute data
vs
RHO
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Other Example:
Common sites
RH
map
1918
Radiation Hybrid
Database
http://corba.ebi.ac.uk:80/RHdb/index.html
http://www.ncbi.nlm.nih.gov/dbEST/
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http://www.ncbi.nlm.nih.gov/cgi-bin/Entrez/map_search?chr=hum_chr.inf&query
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Scale
on
chromosome
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Scale
on
chromosome
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