Professional Documents
Culture Documents
in a Changing World
SEVENTH EDITION
Jeffrey S. Nevid / Spencer A. Rathus / Beverly Greene
Chapter 12
(Pp 410-422)
Schizophrenia
and Other
Psychotic
Disorders
Theoretical Perspectives
Psychodynamic Perspectives
Within the psychodynamic perspective, schizophrenia
represents the overwhelming of the ego by primitive sexual or
aggressive drives or impulses arising from the id.
These impulses threaten the ego and give rise to intense
intrapsychic conflict.
Under such a threat, the person regresses to an early period in
the oral stage, referred to as primary narcissism.
Learning Perspectives
Although learning theory does not offer a complete
explanation of schizophrenia, the development of some forms
of schizophrenic behavior can be understood in terms of the
principles of conditioning and observational learning.
From this perspective, people with schizophrenia learn to
exhibit certain bizarre behaviors when these are more likely
to be reinforced than normal behaviors.
Social-cognitive theorists suggest that modeling of
schizophrenic behavior can occur within the mental hospital,
where patients may begin to model themselves after fellow
patients who act strangely
Biological Perspectives
Although we still have much to learn about the
biological underpinnings of schizophrenia, most
investigators today recognize that biological
factors play a determining role through:
Genetic Factors
Biochemical Factors
Viral Infections
Brain Abnormalities
TRUTH or FICTION
If you have two parents with schizophrenia,
its nearly certain that you will develop
schizophrenia yourself
Genetic Factors
The closer the genetic relationship between schizophrenia
patients and their family members, the greater the likelihood
(or concordance rate) that the relatives will also have
schizophrenia.
Overall, first-degree relatives of people with schizophrenia
(parents, children, or siblings) have about a tenfold greater
risk of developing schizophrenia than do members of the
general population.
The fact that families share common environments as well as
common genes requires that we dig deeper to examine the
genetic underpinnings of schizophrenia.
Biochemical Factors
Contemporary biological investigations of schizophrenia have
focused on the role of the neurotransmitter dopamine.
The leading biochemical model of schizophrenia, the
dopamine hypothesis, posits that schizophrenia involves
an overreactivity of dopamine transmission in the brain.
Increasing evidence supports the view that schizophrenia
involves an irregularity in dopamine transmission in the brain
The imbalance seems to be related to D2 neurons in the
frontal lobe of the brain.
Biochemical factors seem to explain Type I or positive
symptoms of schizophrenia.
TRUTH or FICTION
Although schizophrenia is widely believed to
be a brain disease, evidence of
abnormalities in the brains of
schizophrenia patients remains lacking
Brain Abnormalities
We have compelling evidence of both structural changes (loss
of brain tissue) and functional disturbance (abnormalities of
functioning) in the brains of schizophrenia patients.
However, we have yet to discover any one source of pathology
in the brain that is specific to schizophrenia or present in all
cases of schizophrenia.
The most prominent finding of structural changes is the loss
of brain tissue (gray matter) of about 5% on the average in
schizophrenia patients as compared to normal controls.
These brain abnormalities are responsible for Type II
(negative) symptoms of schizophrenia.
Family Theories
Note that the question of whether stress directly triggers the initial
onset of schizophrenia in genetically vulnerable individuals is still
open to debate (Walker & Diforio, 1997)
Endophenotypes?
To better understand how schizophrenia develops, we need to
dig under the surface to see how genes affect underlying
processes, and how these processes in turn contribute to the
development of the disorder.
Investigators are studying a number of possible
endophenotypes in schizophrenia- measurable processes
or mechanisms not apparent to the naked eye, which are the
means by which an organisms genetic code comes to affect its
observable characteristics or phenotypes.
These phenotypes include disturbances in brain circuitry,
deficits in working memory and cognitive abilities, and
abnormalities of neurotransmitter functioning.
The End