Professional Documents
Culture Documents
Clubs
in human
brain
20110202 Kwon
Taegyun
2015 Spring Brain
dynamics
Review on :
I, We have rich
clubs
Contents
1. Defining networks: Hubs & Rich
Clubs
- what are they?
2. Structural hubs and functional hubs
- where are they?
3. Roles of Hubs
- are they important?
1.
Defining
networks: Hubs
& Rich Clubs
Networks in brain
Modularity
Efficient communication
emotion, social cognition, language
Identifying hubs
Node degree (degree centrality)
Average distance(Closeness)
Betweenness centrality
Vulnerabilty
Eigen-vector centrality, Pagerank
centrality
Highly correlated!
Rich Clubs
Highly interconnected than
prediction
Structural core
-determined by recurcive prouning
Rich Clubs
Links over long distances
->direct communication paths,
shorter
transmission delay
High level of wiring volume/ white
matter organization(with high density
of spine)
->high level of robustness
High demands on metabolic activity
->high-cost, high-value optimization
Summary of
1st section.
-Several ways to define hubs, but results are
related.
-Rich club is not just group of hubs
-Seems our brain network get adventage from Rich
clubs. And its universial.
-Characteristics of hubs are heritable
2.
Structural hubs
and functional
hubs
Functional
network
Do not represent
anatomical
connetion. Nonstationary and time
dependent,
modulated by task.
fMRI/EEG/MEG
Structural Hubs
Densely connected with central
position
- precuneus, anterior and posterior cingulate
cortex, insular cortex, superior frontal
cortex, temporal cortex, and lateral parietal
cortex
Structural vulnerability
-precuneus, insular, superior parietal, and
superior frontal regions
Structural Hubs
Node degree and betweenness
centrality - precuneus and superior
frontal gyrus
Structural Hubs
Functional Hubs
Concentrated area of functional
connectivity
- ventral and dorsal precuneus, posterior
and anterior cingulate gyrus, ventromedial
frontal cortex, and inferior parietal region
Step-wise connetivity(coactivation)
- superior parietal and superior frontal
cortex and the anterior and posterior cingulate
gyrus , portions of the anterior insula
Functional Hubs
Functional Hubs
Participation of multiple functional
networks
-superior frontal cortex, anterior cingulate
cortex, and precuneus/posterior cingulate
gyrus
Summary of
2nd section.
-Structual hubs and Functional hubs are different.
But related.
3.
Roles of Hubs
Individual diffeneces
Intelligence
-communication efficiency of medial parietal
and prefrontal hub regions
Personality traits
Roles on
integration
Brain dysfunction
Schizophrenia
Reduced frontal hub connectivity
Disturbed rich club formation in patients as
well as their offspring
Evidence for long-standing dysconnectivity
hypothesis.
Brain dysfunction
childhood-onset schizophrenia
Disrupted modular architecture
Disturbed connectivity of network connector
hubs in multimodal association cortex
Brain dysfunction
Alzheimers disease &
Frontotemporal dementia (FTD)
Medial parietal and frontal regions in the
etiology of these disorders, regions that
have high spatial overlap with network hubs.
Brain dysfunction
Lesions or traumatic injury to cortical
network hubs
-> behavioral and cognitive brain
functioning
Brain dysfunction
White matter damage
-> cognitive decline
Brain dysfunction
disruption of connectivity of cortical
hub regions
-> diminished or reduced levels of
conscious awareness
Brain dysfunction
Brain dysfunction
Metabolic activity
in parietal
precuneus and
posterior cingulate
hub regions.
Brain dysfunction
Better understanding about disorder
from the function of hubs that are
related
Vice versa. Get better understanding
of functions of the hubs
Can expect applications
Conceptual approach
Prospective of efficient signal
transmission and information flow
Hubs may play the role of Bottle
neck of information flow.
-> can define information flow limit
Essential for serializing of mental
operation
Conceptual approach
With directionality, hubs can be
Source or Sinks
-frontal and paracingulate cortex as
net receivers
-cingulate, entorhinal, and insular
cortex as net emitters
We can think them like driven hubs
and driving hubs
Conceptual approach
There exist multiple functional
domains overlaps
They can be functional workspace,
where the different information can
interactive each other.
Conceptual approach
Model of synchrony-based activity
dependent rewiring shows hubs can
have high probability of rewiring
Scale-free network(where hubs are
exist) shows highest functional
diversity among other network model
Summary of
3rd section.
-Based on empirical findings and conceptual
approach, we can suppose many roles of hubs
Limitations of Network
model
Can not measure intra-regional
projection, which is large portion of
all connetion.
Ignored time-varing factors, such as
firing rate or neuron.
Ignored preference, and accecibility.
Contents
1. Defining networks: Hubs & Rich
Clubs
- what are they?
2. Structural hubs and functional hubs
- where are they?
3. Roles of Hubs
- are they important?
Thanks!
Any questions?
Reference
Slide 9 - "Disassortative network demonstrating the Rich Club effect" by Mdippel Own work. Licensed under CC BY-SA 4.0 via Wikimedia Commons
http://commons.wikimedia.org/wiki/File:Disassortative_network_demonstrating_th
e_Rich_Club_effect.png#mediaviewer/File:Disassortative_network_demonstrating_
the_Rich_Club_effect.png
Credits