Professional Documents
Culture Documents
Outline
Basic anatomy and physiology of the heart
Cardiac measurements and diagnosis
Origin and characteristics of heart sounds
Techniques for heart sound analysis
Applications of heart sound analysis
Cardiovascular Anatomy
Modulating Systems
The autonomous nervous system
The hormonal system
The respiratory system
Mechanical factors
Electrical factors
Multi-System Interactions
arterial pressure
venous pressure
venous return
Hormonal
System
(Epinephrine,
Insulin)
Autnonomous
Nervous
Sysetm
contractility
compliance
preload, afterload
pacemaker rate
Cardiac
Electrical
System
Respiratory
System
(thoracic
pressure)
action potentials
Electroca
rdiogram
Cardiac
Mechnical
System
Phonocar
diogram
resistance
compliance
blood flow
Echocard
iogram/
Doppler
Vascular
Mechnical
System
Pressure
wave
Multi-Signal
Correlations
Ventricular pressure
Aortic pressure
Atrial pressure
Aortic blood flow
Venous pulse
Electrocardiogram
Phonocardiogram
Berne R.M., Levy M.N.,
Cardiovascular Physiology, 6th edition
Heart Disease
Heart failure
Coronary artery disease
Hypertension
Cardiomyopathy
Valve defects
Arrhythmia
Cardiac Measurements
Volumes:
Cardiac
output CO=HR*SV
Stroke volume SV=LVEDV-LVESV
Ejection fraction EF=SV/LVEDV
Venous return
Pressures:
Left
Time intervals:
Pre-ejection
period
Left ventricular ejection time
10
Cardiac Diagnosis
Invasive
Right
Non-invasive
Electrocardiography
Echocardiography
Impedance
cardiography
Auscultation & palpitation
11
Heart Sounds
Valvular theory
Vibrations
of the heart
valves during their closure
Cardiohemic theory
Vibrations
of the entire
cardiohemic system: heart
cavities, valves, blood
Rushmer, R.F., Cardiovascular
Dynamics, 4yh ed. W.B. Saunders,
Philadelphia, 1976
13
14
Low frequency
S1
Low intensity
Transient
50-100
ms
Non-stationary
Overlapping components
Sensitive to the transducers properties and
location
15
Sub-Components of S1
16
Sub-Components of S2
17
Segmentation
External references (ECG, CP)
Timing relationship
Spectral tracking
Envelogram
Matching pursuit
Adaptive filtering
19
Decomposition (1)
Quadratic
TFR
20
Decomposition (2)
(AR)
Autoregressive Moving Average (ARMA)
Adaptive spectrum analysis
21
Decomposition - Example
WVD
CWD
STFT
CWT
22
Feature extraction
Morphological features
Dominant
frequencies
Bandwidth of dominant frequencies (at -3dB)
Integrated mean area above -20dB
Intensity ration of S1/S2
Time between S1 and S2 dominant frequencies
AR coefficients
DWT-based features
23
Classification
Methods:
Gaussian-Bayes
K-Nearest-Neighbor
Artificial
Neural-Network
Hidden Markov Model
Rule-based
Classes:
Normal/degenerated
bioprosthetic valves
Innocent/pathological murmur
Normal/premature ventricular beat
24
Classification - Example
25
26
Signal Processing
high-pass filter
300Hz low-pass filter
Smoothed
Pseudo-Wigner-Ville distribution
Orthonormal wavelet transform
28
Feature Extraction
SPWVD features:
Maximum
instantaneous
frequency of A2,P2
The splitting interval
between A2 and P2
OWT features
(for each scale):
Maximum
value
The position of the
maximum value
The energy
29
A feed-forward, back-propagation
ANN with one hidden layer
The significance of the features
and the size of the network were
evaluated
Training was conducted using 2/3
of the data using errorminimization procedure
The NN estimations were
averaged for series of beats and
compared to the measured PAP
30
Results
32
Sakamoto T. et al.,
Circ. Res., 1965
33
The transducer
measures acceleration
The acceleration is the
second derivative of
displacement/pressure
Pressure can be
estimated by
integrating the PCG
34
S2
S1
S4
OS
EJ
M1T1
IVCT
PEP
S3
S4
A2P2
LVET
M1T1
IVRT
LVFT
35
36
Summary
Heart sounds/vibrations represent the
mechanical activity of the cardiohemic
system
The heart sound signal can be digitally
acquired and automatically analyzed
Heart sound analysis can be applied to
improve cardiac monitoring, diagnosis and
therapeutic devices
37
!Thank You
it
s
(
)
w
(
t
)
e
d
STFT
S (t , )
CWT
S (t , a ) 1
WVD
S (t , ) z (t 2) z * (t 2)e it d
a s (t ) g * ( t a )d
t 2 2 i 0 t
g (t ) e
z (t ) s (t ) iH (t )
CWD
S (t , )
[( u t ) 2 /( 4 2 / )]it
s (u 2) s (u 2) e
*
dud
39
AR
y (n) ak y (n k ) Gx(n)
p
ARMA
k 1
y (n) ak y (n k ) G bl x(n l )
k 1
l 0
Adaptive spectrogram
AS (t , f ) 2 A i e
2
i
[( t ti ) 2 / i2 ) 2 i2 ( f f i ) 2 ]
40
SPWVD
S (t , ) q ( )[ g ( s t ) x( s 2) x( s 2)ds ] e
q ( ) h( 2)h( 2)
OWT
OWT (k , j ) 2 j / 2 x( s ) (2 j s k )ds
41