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Outline
incidence of underfeeding in the ICU
nutritional screening tools available for use in ICU
familiar with the novel approach used to assess the
nutritional risk of critically ill patients and implications
of this risk assessment for clinical practice
SCREENING
Malnutrition
goes
undetected
Guidelines ASPEN/SCCM
2009
Screening
Assessment
Monitoring & Outcome
Communication
Audit
Kondrup et al. Clin Nutr 22(4):415-421;2003.
Subjective Global
Assessment
In the ICU..
Caloric debt/underfeeding
Malnutrition exists 34% or >
Historical nutrition data n/a
Not all patients equal
Consider
Inflammation
Acute diseases
Chronic diseases
Chronic
-Reduced po intake
-pre ICU hospital stay
Starvation
Nutrition Status
micronutrient levels - immune markers - muscle mass
Acute
-IL-6
-CRP
-PCT
Inflammation
Chronic
-Comorbid illness
Objective
Develop a score using the variables in the model to
Quantify the risk of ICU pts developing adverse
events that may be modified by nutrition
Non-survivors by day 28
(n=138)
Survivors by day 28
(n=460)
p values
<.001
<.001
<.001
<.001
0.13
0.66
<20
20
6 ( 4.3%)
122 ( 88.4%)
3.0 [2.0 to 4.0]
# of co-morbidities at baseline
Co-morbidity
Patients with 0-1 co-morbidity
20 (14.5%)
Patients with 2 or more co-morbidities
118 (85.5%)
25 ( 5.4%)
414 ( 90.0%)
3.0 [1.0 to 4.0]
<0.001
<0.001
140 (30.5%)
319 (69.5%)
108.0 [59.0 to 192.0]
0.07
<.001
<.001
Non-survivors by day 28
(n=32)
Survivors by day 28
(n=139)
p values
0.10
0.0[ 0.0 to
0.0]
0.06
p values
Number of
observations
Age
Baseline APACHE II score
Baseline SOFA
-0.1891
-0.3914
-0.3857
<.0001
<.0001
<.0001
598
598
594
0.1676
0.0234
183
-0.1387
0.0007
598
-0.1828
0.0581
-0.0832
-0.1539
-0.3189
-0.2908
0.0130
0.1671
0.0420
0.0002
<.0001
<.0001
184
567
598
589
582
581
Variable
Exact Quintile
Parameter
Points
19.3-48.8
referent
48.9-59.7
0.780
59.7-67.4
0.949
67.5-75.3
1.272
75.4-89.4
1.907
APACHE II
SOFA
# Comorbidities
Range
<50
50-<75
>=75
<15
15-<20
20-28
>=28
<6
6-<10
>=10
0-1
2+
Points
0
1
2
0
1
2
3
0
1
2
0
1
0-<1
1+
0
1
IL6
0-<400
400+
0
1
AUC
Gen R-Squared
Gen Max-rescaled R-Squared
0.783
0.169
0.256
BMI, CRP, PCT, weight loss, and oral intake were excluded because they were not significantly
associated with mortality or their inclusion did not improve the fit of the final model.
Observed
Model-based
20
40
Statistical
modeling
n=12
n=33
n=55
n=75
n=90
n=114
n=82
n=72
n=46
n=17
n=2
60
80
10
higher
score =
higher
mortality
Observed
Model-based
10
8
2
high score
= longer
ventilation
n=12
n=33
n=55
n=75
n=90
n=114
n=82
n=72
n=46
n=17
n=2
10
12
14
1.0
0.6
0.2
0.4
0.0
28 Day Mortality
0.8
NUTRIC 0-3
NUTRIC 4-6
NUTRIC 7-8
NUTRIC 9-10
50
100
Nutrition Adequacy Levles (%)
150
Age
APACHE II
SOFA
# comorbidities
Days in hospital pre ICU
IL 6
Applications of NUTRIC
Score
Help determine which patients will benefit more from
nutrition
Supplemental PN
Aggressive feeding
Small bowel feeding
Limitations
Conclusion
Thanks
Dr. Daren Heyland
Xuran Jiang
Andrew Day