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An Overall View
The Structural and Functional Blueprint of
Neurons is Similar to Epithelial Cells
Membranous Organelles Are Selectively
Distributed Throughout the Neuron
The Cytoskeleton Determines the Shape of the
Neuron
Golgi
Dendrite
Golgi
ER
Nucleus
dendrite
axon
Microtubules
subunits: - and -tubulin
25-28 nm in diameter
polar, dynamic structure
tubulin is a GTPase; microtubules
grow by addition of GTP-bound
tubulin dimers at plus end.
microtubule-associated protein (MAP)
mostly to stabilize or enhance
microtubule assembly
axon: tau (causing microtubules
to form tight bundles in axon)
and MAP3
dendrite: MAP2
13
Neurofilaments
cytokeratin family including
glial fibrillary acidic protein
(GFAP)
10 nm in diameter
stable polymers
neurofibrillary tangle in
Alzheimers disease patients
1 neurofilament 32
monomer
8 protofilaments in each
neurofilament
4 monomers in each
protofilament
Microfilaments
subunits: - and -actin monomer
3-5 nm in diameter
polar, dynamic structure
ATP
With actin-binding proteins, actin
filaments form a dense network lying
underneath the plasmalemma. This
matrix plays a key role in the
formation of pre- and postsynaptic
morphologic specializations.
microfilament
-tubulin
-tubulin
(G)
cytokeratins
GFAP etc
(F)
-actin
-actin (G)
GTP
none
ATP
25-28 nm
10 nm
3-5 nm
dynamic but
more stable in
mature axons
and dendrites
stable and
polymerized
dynamic,
of the actin in
neurons can be
unpolymerized
den
den
extensive dendritic
structures
acetylcholine
multipolar
receive inputs throughout its
dendrites and cell body, with
inhibitory synapses on the
cell body close to trigger
zone and excitatory ones
located farther out along the
dendrites
CA1
CA1
CA3
CA3
CA3
CA1
CA3
Charcot-Marie-Tooth Disease
This disease is
characterized by
progressive muscle
weakness, greatly
decreased conduction
in peripheral nerves,
as well as cycles of
demyelination and
remyelination.
Duplication of
peripheral myelin
protein (PMP22)
gene on chromosome
17 causing overproduction of this
Schwann cell protein.
An Overall View
Four distinctive compartments in nerve cells
Cell