Professional Documents
Culture Documents
EVOLUTION OF THE
NUCLEAR GENOME
PRINCESS LORRAINE GARCIA
BS-BIOLOGY IV
Chromosome territories
Mitotic Chromosomes
Chromosome 1 (red),
Chromosome 9
(green)
Chromosome Territories
Replication Sites
act
Ex
tr
trix
Transcript Tracks
Nuclear
Ma
ing
Splicing Factors
Transcription Sites
Domains)
Domains)
Hierarchical Epigenetics of
the Cell Nucleus
Alterations of nuclear organization at all levels
affect gene regulation which in turn affects cell
function and phenotypic expression
Molecular level (DNA methylation and
histone acetylation)
Chromatin domains (unfolding of
chromatin loops)
Chromosome Territories (changes in
shape/gene positions)
Global Organization of CT (3-D
interactions)
Knowledge Base
for Normal &
Disease States
Anti-lamin A
DNA (DAPI)
Anti-lamin A
DNA (DAPI)
extract
Anti-lamin A/C
Anti-lamin B