Lecture Overview

Lymphatic

System and Components

What is lymph and how does it travel?

General

Immune Reaction- Inflammation

What is one function of the cells carried in

lymph?

Selected

Topics in Immunity

Lymphatic System
Absorbs

excess fluid from the tissues

Returns

this fluid to the circulatory system

or the heart

Additional

function in Immunity

Components of the Lymphatic

System
Lymph
Lymphatic

Tissue
Lymphatic Vessels
Thymus
Bone Marrow
Spleen

Lymph
Lymph

The clear fluid

absorbed by
the lymphatic
system

Lymphatic Tissue

Clusters of

Lymphocytes
and
macrophages

Lymphatic Tissue
Malt: (Mucosa Associated Lymphatic Tissue)
Diffuse array of lymphocytes found along body

passages in mucous membranes.

Examples of malt: lining of the stomach and
respiratory tract
Lymph

nodules:

Dense clusters of Lymphocytes

Transient: pop up during infection

Lymphatic Vessels
Carry

and Transport
Lymph and proteins

Similar

Structure to veins
Tunica Interna: Thin
inner lining and valves
Tunica Media: Elastic
fibers and Smooth
Muscle
Tunica Externa: Thin
Outer Layer

Lymphatic Filters
Nodes- Screen and Filter
Lymph for infectious particles

Lymph

Spleen-

Screen and Filter Blood for

old, dead cells and infectious particles

Subclavian
2 collecting Trunks
6 Lymphatic Trunks
More Collecting Vessels
Lymph Nodes
Collecting Vessels
Lymphatic Vessels

Lymphatic Movement
No

pump

Rhythmic
Skeletal
How

contraction of the lymph vessels

Muscles

is backflow prevented?

Immune Cell Generators

Bone

Marrow- Makes B- Cells

Thymus-

Makes T- Cells

Thymus

Break for
Dynamic Human

Inflammation
Non-specific

infection

response to tissue trauma or

4 signs of Inflammation

4 signs of Inflammation
Redness
Swelling
Heat
Pain
Whats the

purpose of pain?

Purpose of Inflammation
Remove

Invading Pathogens

Remove

Debris of Damaged Tissues

Initiate

Tissue Repair

Mediators of Inflammation
Chemical

Messengers

Leukocyte

Chemical Messengers
Released

by mast cells in response to damage

Bradykinin,

Histamine, and Leukotrienes

Increases Local Blood Flow to distressed area

Stimulates Vasodilation
Increases Permeability of Capillaries

Whats Accomplished?

Chemical Messengers
Bradykinin,

Histamine, and Leukotrienes

Increases Local Blood Flow

Stimulates Vasodilation
Increases Permeability of Capillaries

Whats Accomplished?
Heats area causes redness and swelling
Dilutes toxins and helps Remove waste
Supplies oxygen and nutrients for tissue repair

Pain Response
Purpose?
Causes?

Pain Response
Purpose?

Prevents further injury to area.

Causes?
Direct Nerve Damage
Pressure from Swelling
Chemical Stimulation particularly bradykinin

Leukocyte Deployment
Leukocyte:

any white blood cell including

T cells, B cells, granulocytes, platelets,
basophils, mast cells, monocytes and
macrophages

Leukocytes
Why?

Migrate toward inflammed area

TO KILL and RECRUIT

Leukocyte Deployment
Leukocytes

Migrate to inflammed tissue

How?

1. Margination or pavementing: To
migrate to the wall of
a capillary
2. Diapedesis: Passage of blood cells
through vessel wall into tissue
3. Chemotaxis: Movement of a cell
towards or away a chemical source

What do the leukocytes plan

to do?
Phagocytosis:
Recruit

release of toxic chemicals

more leukocytes

Phagocytosis
Leukocytes

consume and destroy foreign

invaders and dead cells

Ejected

as Pus

Break for
Dynamic Human

Selected Topics in Immunity