Professional Documents
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Antipsychotic Drug
Prepared By
Md.Sayeed Ahmed
Nafisa yeamin
ID:1531293672
152225
disorders
Psychoses
False
perceptions (Hallucinations)
False
beliefs (Delusions)
Affective Disorders
Emotional
disturbances:
Mood is very low (Depression)
Mood is very high (Mania)
Schizophrenia
Hypofrontality hypothesis
Linked hypothesis
Antipsychotic Drugs
Mechanisms of action
-competitive blockade of dopamine receptors and serotonin receptors
-adverse effect result from blockade of different receptors
They have an equal or greater affinity for D2 receptors than for 5-HT2
receptors
eg clozapine have a greater affinity for 5-HT2 receptors than for D2 receptors
Inactivation of
Continued
Continued
Drug Classification
Phenothiazines
Chlo. And Thio. lower potency, more autonomic side effects and fewer
extrapyramidal side effects than high potency
Blockade of D2 receptors
Behavioural improvement
Adverse effects
1- Extrapyramidal side effects
-Acute: 1- Akathisia
2- Pseudoparkinsonism
3- Dystonias
-Chronic: Tardive dyskinesia
continued
2- neuroleptic malignant syndrome
3-increase serum prolactin levels
4-impair thermoregulation cause poikilothermy
Decrease dose
Decrease dose
Drug treatment
Continued
Neuroleptic malignant syndrome
Supportive care
Discontinuing of drug
Administration of bromocryptine
Change to atypical
Indication of Phenothiazines
Schizophrenia
Drug-induced psychosis
Dementia
In compare with thioridazine, cause fewer autonomic side effect and more
extrapyramidal side effects
Thioxanthenes
Butyrophenones
Azepines
Clozapine has fewer extrapyramidal side effect and greater activity against
negative symptoms and its use is with 1.3% first year incidence of
potentially fatal agranulocytosis.
continued
Olanzapine is:
As effective as haloperidol in alleviating of positive symptoms.
Superior to haloperidol in alleviating of negative symptoms.
Fewer extrapyramidal side effects
At high doses may cause akathisia, pseudoparkinsonism, and
dystonias.
Risperidone