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GIA
MENINGOSEPTICA
Dr.T.V.Rao MD
4/6/16
Dr.T.V.Rao MD
Elizabethkingia
meningoseptica
Elizabethkingia
meningoseptica is a
gram-negative rodshaped bacterium
widely distributed in
nature (e.g. fresh
water, salt water, or
soil). It may be
normally present in
fish and frogs but is
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Dr.T.V.Rao MD
History of Elizabethkingia
In
1959, the
American
bacteriologist
Elizabeth O. King
(who isolated
Kingella in 1960)
was studying
unclassified
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Dr.T.V.Rao MD
meningoseptica has
been deemed a
potentially important
threat to patients in
critical care areas
because of its
multidrug-resistant
phenotype and its
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found in
the environment,
particularly in soil
and water,
Elizabethkingia rarely
causes disease in
otherwise healthy
individuals.
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Dr.T.V.Rao MD
are
bacteria that are
rarely reported to
cause illness in
humans, and are
uncommon
colonizers of the
respiratory tract
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Dr.T.V.Rao MD
Present outbreak
In
Dr.T.V.Rao MD
E.
General Characteristics
E.
meningoseptica
meningoseptica
4/6/16
is a species of
Gram-negative,
obligate
aerobic, nonfastidious, nonspore forming,
nonfermentative
; nonmotile;
slender; slightly
Dr.T.V.Rao MD
Elizabethkingia
Elizabethkingia
4/6/16
is a genus of
bacteria
commonly found
in the
environment
worldwide and
has been
detected in soil,
river water and
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4/6/16
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Three individual
Elizabethkingia
anophelis colonies
growing next to
each other on
blood agar. Photo
courtesy CDC
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Biochemically reacting
Catalase
positive, oxidase
positive, and indole-positive,
OF glucose ox+/F-, urease
negative (contrast E.
miricola which is urease
positive), mannitol positive,
non-nitrate-reducing
saprophytic bacilli. It is
gelatinase, esculin, ONPG &
DNAse positive.
Chryseobacteria
(Flavobacteria)
are in
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general indole positive in
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meningoseptica
Growth Characters
grows well in regular
E.
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incubators on blood
agar and chocolate
agar. Colonies are
very pale yellow and
may not be easily
evident at 24 hours.
E. meningoseptica
strains either are not
pigmented or
produce a weak
Dr.T.V.Rao MD
yellow nondiffusible 13
Infection
E.
meningoseptica
predominantly
causes outbreaks of
meningitis in
premature newborns and infants in
neonatal intensive
care units of
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Transmission and
Sources of the Infection
Neonatal
infections due
to C. meningosepticum
could be through vertical
transmission; however, no
data about this kind of
transmission of the
organism is available. As
many interventions
(endotracheal intubation,
central
and
peripheral
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intravascular
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Can be a nosocomial
Infection
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Majority of the C.
meningosepticum
infections reported
have been in NICUs,
the infections of
these neonates are
often considered as
nosocomial
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Some
Infection
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Infection
Only
recently has
it also been
found to cause
soft tissue
infection and
sepsis in the
immunocompeten
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multiresistant to
antibiotics typically
prescribed for treating
gram-negative bacterial
infections, including
extended-spectrum betalactam agents (due to
production by most strains
of two beta lactamases:
one ESBL and one Class B
Carbapenem-Hydrolyzing
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metallolactamase),
20
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vancomycin
has been used in the
past, its high MIC (16
g/ml) has led to a
search for
alternatives,
especially for
meningitis. Presently
ciprofloxacin,
minocycline,
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Hypoalbumine
Predictors of poor
outcome
mia, increased
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pulse rate at
the onset of
infection, and
central venous
line infection
were
associated
with a poor
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CDC
Trends in management of
outbreaks
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of Gram-negative
bacterial infections are usually
due to transient carriage of
the organisms on the hands of
healthcare workers .
Susceptible patients may
become colonized after
acquiring the organism from
the healthcare worker, and
infection may or may not
develop.
Hand
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on Elizabethkingia
Medscape
Infectious diseases
WIKIPEDIA
ON LINE RESOURCE
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Program
doctortvrao@gmail.com
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