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Venereal warts
(condyloma acuminatum)
Condyloma
VIN
Diffuse cellular atypia
Nuclear crowding
Pathologic mitosis
SQUAMOUS CELL CA
SQUAMOUS CELL CA
SQUAMOUS CELL CA
SARCOMA BOTRYIOIDES
(embryonal rhabdomyosarcoma)
SARCOMA BOTRYOIDES
SARCOMA BOTRYOIDES
SARCOMA BOTRYOIDES
CERVIK
ANATOMY
CERVIX
Post-menopausal cervix
ANATOMY
(TRANSFORMATION
ZONE)
ANATOMY (TRANSFORMATION
ZONE)
Cervicitis - metaplasia
SQUAMOUS METAPLASIA
ENDOCERVICAL POLYP
POLYP
Carcinoma: pathophysiology
EXPOSURE TO HPV
Carcinoma: pathophysiology
Carcinoma: pathophysiology
Carcinoma: pathophysiology
Spectrum of CIN
Invasive Ca of Cervix
CIN III
SCC
MICROINVASIVE SCC
SCC
SCC, keratinized
SCC
Staging
Stage 0
Carcinoma in situ
Stage Ia
Microinvasive and confined to cervix
Stage Ib
Invasive and confined to cervix
Stage IIa Extends to upper vagina but not to parametrium
Stage IIb Involve parametrium
Stage III
Extension to pelvis sidewall or lower vagina
Stage IV
Beyond the pelvis or involvement of rectal or
bladder mucosa
U T E R U S
ENDOMETRIAL HYPERPLASIA
Simple/Swiss cheese
Complex hyperplasia
Atypical hyperplasia
Squamous metaplasia
II.
ENDOMETRIAL
GLANDULAR
TUMORS
Endometrioid
Carcinoma
Relations among proliferation
hyperplasia, atypical hyperplasia, and endometrial Ca.
IV.
ENDOMETRIAL POLYPS
-Often pedunculated, may be solitary
or multiple
-Commonly composed of hyperplastic
endometrium with cystically dilated
glands, cellular stroma, and thick
walled vessels
-May cause intermittent bleeding, 3%
harbor adenocarcinoma
Endometrial Polyp
Histological Grading
Endometrioid Carcinoma
MYOMETRIAL TUMORS
LEIOMYOMA
A. Well demarcated white appearance mass bulging into the uterine cavity
B. Well differentiated spindle shaped cells in interlacing bundles
LEIOMYOSARCOMA
A. Large hemorrhagic tumor mass distends to the lower corpus and flanked
by two leiomyomas
B. The tumor cells are irregular in size & shape, with hyperchromatic nuclei
LEIOMYOSARCOMA
Leiomyosarcoma
Leiomyoma
Mitosis
ECTOPIC PREGNANCY
ECTOPIC PREGNANCY
HYDATIDIFORM MOLE
HYDATIDIFORM MOLE
Normal-looking
villi
Partial mole
Complete mole
INVASIVE MOLE
CHORIOCARCINOMA
!-HCG: choriocarcinoma
(IH) x 200
OVARY
NON-NEOPLASTIC
OVARIAN ENLARGMENT
NEOPLASTIC OVARIAN
ENLARGEMENT (80% are
benign)
NON-NEOPLASTIC
OVARIAN ENLARGMENT
A. Germinal Inclusion Cyst
- common cyst in pre-menopausal period, result of down growth
and entrapment of the surface epithelium into the ovarian cortex
B. Physiologic or Functional Cyst
- follicle cyst
- corpus luteum cyst
- theca lutein cyst
C. Polycystic ovaries
D. Stromal Hyperplasia stromal hyperthecosis
FOLLICLE CYST
OF THE OVARY
The rupture of the thin walled follicular cyst led to abdominal hemorrhage
POLYCYSTIC OVARIES
POLYCYSTIC OVARIES
(polycystic disease of the ovary)
Cut section of the ovary show numerous cysts embedded in sclerotic stroma
Pathogenesis
Stromal Hyperthecosis
Histogenesis of
Serous Tumor
Mucinous Cystadenoma
Serous cystadenocarcinoma
Mucinous cystadenocarcinoma
Brenner Tumor
Brenner tumor
Characteristic epithelial nest within ovarial stroma
Tumor jinak pada berbagai umur, separo timbul pada umur > 50 th.
Nama lain: tumor sel transisional
Brenner tumor
Fibroma -- fibrothecoma
-Most (90%) are unilateral, solid, round, firm, white masses 5-10 cm in size
-Some time a thecal component may be present fibrothecoma
-When the size >6cm 40% patients will develop ascites and right-sided
pleural effusion (Meigs syndrome)
Fibroma ovarii
Meig syndrome
Dermoid cyst
A mixture of tissues
Hair intermingled with
butter-like substance
Mature teratoma
(HE) x 25
Immature teratoma
Immature teratoma
(HE) x 25
Immature Teratoma
Primitive
neuroepithelium
Yolk-sac Carcinoma
Schiller-Duval bodies
Dysgerminoma ovarii
Polyhedral tumor cells with central round nuclei and adjacent inflammation.
The neoplastic cells have clear, glycogen filled cytoplasm.
DYSGERMINOMA 0VARII
Metastatic Tumors
Krukenberg tumor
Pseudomyxoma Peritonei
( from appendix)
OVARY