Skizofrenia simplex

Prognosis
Several studies have shown that over a period of 5 to 10 years after the first psychiatric
treatment in hospital because skiofrenia, only approximately 10-20% of patients can be described
possess baik.Lebihresults of 50% of patients can be described as having a poor outcome , with
hospital care are repeated, exacerbation of symptoms, episodes of severe mood disorders, and
suicide attempts. Although the numbers are not good, schizophrenia does not always have a
disease that is bad, and a number of factors have been associated with a good prognosis.
Range of recovery figures reported didialam literature is of 10-60% and a reasonable estimate
is that 20-30% of all patients with schizophrenia are able to live a somewhat normal
life. Approximately 20-30% of patients continue to experience symptoms that are, and 40-60% of
patients continue SCARA significantly disturbed by the interference during his whole life.
In general, the prognosis of schizophrenia depends on:
1. Age was first raised (onset): getting younger worse.
2. At the onset of acute or chronic: Acute better when.
3. Type schizophrenia: acute schizophrenic episodes and catatonic better.
4. Fast, precise and orderly treatment obtained.
5. The presence or absence of factors originators: if there is better.
6. Presence or absence of heredity: if there is more ugly.
7. Personality prepsikotik: if schizoid, skizotim or introvred worse.
8. Socioeconomic circumstances: when a low worse.

Prognosis
Good
Slow onset
Clear
precipitati
ng factors
Acute onset
Social
history,
sexual and
workgood
premorbid
Symptoms
of
mood
disorders
(especially
depressive
disorder)
Getting
Married
Family
history of
mood
disorders
Good
support
system
Positive

Poor Prognosis
Young Onset
There is no trigger factor
Onset is not clear
Social history and poor premorbid work
Withdraw or autistic behavior
Not married, divorced or widow / widower
Poor support system
Negative symptoms
Signs and symptoms of neurologic
Traumatic history of perinatal
There is no remission in 3 years
Many relapse
History assault

Teraphy
Somatic Therapy
Antipsychotics
Antipsychotic drugs including three
main classes, namely:
1.Dopamine receptor antagonists
2.Risperidone (ris perdal)
3.Clozapine (Clozaril)
Selection of Drugs

 1.Dopamine Receptor Antagonists

Is a classic antipsychotic drugs and effective in the treatment of
schizophrenia.This drug has two main shortcomings, namely:
Only a small number of patients, helped enough to regain sufficient
number of normal mental function.
Accompanied by adverse effects and serious disturbing.Most major
disruptive effects are akathisia and parkinsonism-like symptoms such
as rigidity and tremor.Potentially serious effects is tardive dyskinesia
and neuroleptic malignant syndrome.

"Remoxipride"is a dopamine receptor antagonist of the

different classes of the dopamine receptor antagonistthat is
currently available.Initially these drugs with significant
neurological side effects, but
eventuallyremoxiprideaccompanied with aplastic anemia, thus
limiting its clinical value.

 2.Risperidone
Antispikotik is a drug with significant
antagonist activity at serotonin receptor
type 2 (5-HT2) and the dopamine
receptor type 2 (d2).Risperidone become
the first-line drugs in the treatment of
schizophrenia because of the possibility
this drug is more effective and safer than
the typical dopaminergic receptor
antagonists.

 3.Clozapine
Is an effective antipsychotic drug.Its mechanism of
action is not known with certainty.Clozapine is a
weak antagonist of the receptor D 2but it is a
powerful antagonist of the receptor D 4and have
antagonistic activity at the receptor
serotogenik.Agranulocytosis is a side effect that
requires monitoring every week on indices of
blood.This is a second-line drug, is indicated in
patients with tardive dyskinesia because available
data stating that clozapine is not accompanied with
the development or exacerbation of the disorder.

 Kaplan & Sadock: "Schizophrenia" in Synopsis of Psychiatry Volume 1, issue 7,

Publisher Development of Visual Literacy, Jakarta, 1997, pages 685-729.
Maslim.R: Guidelines for Classification and Diagnosis of Mental Disorders in
Indonesia, third edition, Mental Health Directorate of the Ministry of Health of
Indonesia, Jakarta, 2002, p 46-51.
WF Maramis, Notes of Life Medical Sciences, University Press, 1980, p: 215-35
Maslim.R: A Practical Guide Clinical Use of Psychotropic Drugs, 3rd edition,
Publisher Section of Psychiatry, Faculty of Medicine Atma Jaya Catholic University,
Jakarta, 2001, p 14-23.
Hawari, Dada: Schizophrenia in Holistic Approach In Mental Disorders, Publisher
Faculty of Medicine, Jakarta, 2003.
http://www.schizophrenia.com
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http://www.idionline.org/infoidi http://www.medicastore.com/cybermed