Professional Documents
Culture Documents
o Additional burden
Transmission
Sexual contact
• Parenteral exposure to blood
• Infected needles
• Vertical
o Antepartum – 30%
o Intrapartum – 70%
Natural history
• 3 distinct patterns of disease
o 15-25% Newborns have rapid course
Infection in–utero
• Immune
o Absolute or percentage of CD4+ cells
• Clinical categories
o Cat A – at least 2 mild symptoms
recurrent sinusitis/OM
o Cat B – moderate
immunosuppression
5
Diagnosis
o Between 3 & 6 m
subsequently – IUI
assay -ve within 48 h of life, +ve after I wk
Prevention
HIVNE Gp1: Lab: Nev, Inf: Nev (BF) Gp1: 13% 47%
T 012 Gp2 :Lab : ZDV, Inf: 1 wk Gp2: 25%
(BF)
Breast feeding 8
o Infant factors
Prematurity
Relative gastric alkalinity 1st few days of
life
Immunogenetic profile of baby
Exclusive BF/Substitutes/Mixed
• Western countries – NO BF
o BM banks
o NO COMBINATION
9
Immunization
Special issues
• Same schedule as HIV non-infected except a few
(live Vaccines)
• Polio: IPV No OPV
o India-OPV
• Pnemococcal vaccine
o Polyvalent >2yr age
o Combination therapy
NRTI + NNRTI
Protease inhibitors
• PCP prophylaxis
• ?Prophlactic ATT
• Care & support for HIV infected children
o Vit A & others
o Psychosocial support
o Orphaned children