Professional Documents
Culture Documents
Virus
(VZV)
J AC QUEL I N E, VAL ERI A , CA RL A
IMBS
REACTIVATION
Herpes zoster (shingles).
(VZV)
nucleocapsid
of
Epidemiology
Reservoir: Human
Transmission
Airborner droplet
Direct contact with lesions
Communicability: days
before /to days after onset
of rash
Pathogenesis
Pathogenesis
Incubation Period:
10 21 days
Asintomatic
Source: Leigh, Z. ; Nandini, S.; Stefan, O.; Ann, A. (2014) Molecular mechanisms of
varicella zoster virus pathogenesis. Nat Rev Microbiol. 2014 March ; 12(3): 197210.
doi:10.1038/nrmicro3215.
TROPISM
T Cell Tropism
Skin Tropism
Neurotropism
. .
.
. . .
.
Symptoms
Incubation period: 14 to 16 days
after exposure. Range: 10 to 21
days.
Other typical symptoms that may begin to appear 1-2 days before
rash include:
Diagnose chickenpox
based
on the characteristic
rash.
Diagnostic
Leukopenia
Relative or absolute lymphocytosis
Liver function test are mildly elevated
Therapy
Analgesics
Calamine
Antihistamines
Immunization
Vaccine: prevent the spread of the disease.
Its complications and subsequent reinfection as herpes zoster.
up to 80 % of cases.
This is given to healthy children between 12 and 18 months
old.
From the 13 years they can be immunized with two doses.
However, not be given to people with
a weak immune system or pregnant
women.
Administrat percutaneous
ion
Immunity
Efficacy
95%
Stability
Storage 2-8 C
Safe
Schedule
Bibliography
Leigh, Z. ; Nandini, S.; Stefan, O.; Ann, A. (2014) Molecular
mechanisms of varicella zoster virus pathogenesis. Nat Rev
Microbiol. 2014 March ; 12(3): 197210. doi:10.1038/nrmicro3215
Morbidity
and
Mortality
Weekly
Report,
available
www.cdc.gov/mmwr/preview/mmwrhtml/mm6112a4.
s_cid=mm6112a4_w.
at
http://
htm?