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Antiglaucoma drug
Beta antagonist
Alpha agonist
Carbonic anhydrase inhibitors(CAI)
Prostaglandin derivatives
Combined fixed medication
High efficacy
minimal ocular side effect
Good compliance (bid. regimen)
Low cost
Carteolol (1-2%)
Non selective beta antagonist
Intrinsic sympathetic activity
Decrease IOP as the same Timolol
SE: mild irritation , local anesthetic
effect, bradycardia, bronchospasm, d
yslipidemia
Betaxolol (0.25-0.5%)
Selective beta1 antagonist
Decrease IOP 20% from baseline
Calcium chanel blocking like action,
benefit for glaucoma patient with circ
ulatory problem at optic nerve head
http://www.reviewofophthalmology.com/content/d/glaucoma_management/i/1226/c/
Prostaglandin derivatives
Reducing intraocular pressure in
people who have open-angle glauco
ma.
Increasing the uveoscleral outflow
Remodel ECM of ciliary muscle and
reduce collagen which increase inter
muscular space
Prostaglandin derivatives
Compan
y
Alcon,
Inc.
Allergan
Inc.
Brand
Name
Travatan
Z
Lumigan
Merck &
Co.
ZIOPTAN
Pfizer
Inc.
Xalatan
Generic Name
Travaprost 0.004%
Bimatoprost 0.01%,
0.03%
Tafluprost
ophthalmic solution
0.0015%
Latanoprost 0.005%
Prostaglandin derivatives
Clinical efficacy
Prostaglandin derivatives
Side effect
Migraine headaches
Gastrointestinal effects
Combined medications
An alternative for patients who need more
than one type of medication.
In addition to the convenience of using one
eye drop bottle instead of two
Cosopt is a combination of a beta blocker
(timolol) and a carbonic anhydrase inhibitor
(Trusopt).
Combigan is new and combines an alpha
agonist (brimonidine) with a beta blocker
(timolol).
Trade name
Timpilo
Cosopt
Azarga
Xalacom
Ganfort
Duotrav
Combigan
Generic name
Timolol + Pilocapine
Timolol +
Dorsolamine
Timolol +
Brinzolamide
Timolol + Latanoprost
Timolol +
Bimatoprost
Timolol + Travoprost
Timolol +