ANFARM HELLAS S.A.

Pharmaceuticals

Since 1967
ANFARM HELLAS S.A. was founded in
1967 by Mr. Apostolos Nicolaou, Chairman of
the Board of Directors to this day.
A p o s t o lo s N ic o la o u
C h a ir m a n
D im it r i N ic o a lo u
V ic e - P r e s id e n t
P la n t D ir e c t o r

E u g e n ia N ic o la o u
M a n a g in g & C o m m e r c ia l
D ir e c t o r

Headquarters
Administration offices and distribution
warehouse are located in the city of Athens.
ANFARM HELLAS S.A.
K.Paleologou & Perikleous 27
15232 Halandri, Athens - Hellas
Tel: 210-6831632
Fax: 210-6836540
e-mail: anfarm@hol.gr

Production Facilities
The production facilities are built in a pollutionfree area, Schimatari of Viotia, about 60 km from
Athens, the capital of Hellas.

ANFARM HELLAS S.A.

Schimatari Viotias
32009 Hellas
tel: 22620 - 58678, 58391
fax: 22620 - 58391

The plants
The plants have been built on the
companys owned land of 20.000 m, with
manufacturing facilities totaling 4.160 m
Plant A: 2.500 m (main)
Plant B: 1400 m (new)
Plant C: 1100 m (new)

The plants

Cephalosporines Production Unit

Automatic washing machine 6.000
vials/h
Automatic tunnel for dry heat
sterilization, 7.000 vials/h
Automatic filling machine for dry
powder injections, 6.000 vials/h

Cephalosporines Production Unit

The above machines are all connected in
an automatic and continuous production
line.
Filling and capping of vials is done in an
environment of class A.
An autoclave for steam sterilization, is
also included in the production line.

Cephalosporines Production Unit

Capsules production line 20.000 caps/h
Coated and non-coated tablets production line
50.000 tabs/h including and automatic coating
machine
Oral Suspensions production line 4.200 bottles/h
Packaging line, consisting of an automatic
blistering Noack and cartooning machine Noack.
Packaging efficiency 6.000 packages/h

Lyophilized and liquid injections

production Unit
Edwards Lyophilizator, surface of 10 m2,
with the possibility of internal capping.
Vials filling machine 6.000 vials/h
Ampoules filling line 15.000 ampoules/h
Filling line of large volume solutions for
infusion 3.000 vials/h

Lyophiles and liquid injections

production Unit
The above lines are supported by the
following equipment:
Washing machine 8.000 vials/h
Dry heat sterilizator capacity 2,1 m3
Steam sterilizator capacity 1 m3

The story ...

1967 Foundation.
1969 Construction of the plant.
1979-81 Merger with Synthelabo France.
1989 Renovation of the Plant
1992 Creation of lyophilization dept.
1996 Renovation of the Sterile rooms
1997 ISO 9002 Certified
1999 Construction of 2 new plants

1999 Supply agreement with ACS Dobfar

2001 Start supplying European Companies

Our philosophy
To develop and produce high-quality generic
drugs at competitive cost, for both the
domestic and international markets.
To follow criteria and methods in order to
demonstrate and record the equivalence of
these generic products compared to the
original proprietary preparations.
We see Generics globally as an equivalent
therapeutic alternative which contributes to
cost reduction - without any loss of quality.

Our aim
Our main aim is to become one of the
leading Greek Pharmaceutical
Manufacturers.

Objectives
Maximize our sales in the domestic
market.
Increase our sales in foreign
markets (exports).
Contract manufacture for Hellenic
and other European companies.
Establish additional relationships
with international companies for
licensing.

Strategies
To achieve high production quality.
To specialize in production (new investments:
lyophilized products, sterile liquids,
cephalosporines).
To constantly renovate the existing facilities with
new instruments and machinery.
To maintain a continuous updated QA and QC
system.
To develop new formulations, new registrations (4
to 5 products per year).

Strategies
To maintain a high standard and dedicated staff.
To provide the resources and tools to our staff.
To maintain a good level of communication, among
the management and the employees of the Company.
To spread, evenly, information throughout the
Company about decisions of the management, new
investments, new cooperations and new projects in
general.
To utilize existing foreign markets (new registrations)
To explore new markets.

Research & Development

Extensive market research is conducted
before launching a product. Also efforts are
made to develop specific products for
specific countries. Generally though, we
develop products hoping that these will
meet the needs of markets in several
countries.
Our research comprises the development of
stable, efficient and tolerable drugs.
Clinical trials and bio-equivalence studies
are conducted wherever needed.

Quality Control / Assurance

QA & QC is achieved by well-trained
professional teams that ensure compliance
to the latest guidelines of European and
American Pharmacopoeias.
QA & QC is rigorously applied in all stages
of production - from the delivery and
storage of raw materials to the release of
finished products-

Quality Control / Assurance

All our suppliers are qualified and our raw
materials are of European Origin.
The Microbiological Department was
recently renovated and the analytical
laboratory is equipped with all the required
modern instruments.

ISO 9002 Certified

ANFARM s chart
V ic e -P re s id e n t
& P la n t D ire c to r
D . N ic o la o u
T e c n ic a l D ire c to r
H . G a k is
P ro d u c tio n
G .F o to p o u lo s
M ic ro b io lo g ic a l
C o n tro ls
A . Z am anou

Q u a lity C o n tro l
A . N ic o lo v ie n i
A n a ly tic a l
C o n tro ls
E . S p y ra k is

R & D
G . G ia n n a c o p o u lo u
A n a ly tic a l
C o n tro ls
P . K a p o u la

Q u a lity A s s u ra n c e
H . G a k is
D o c u m e n ta tio n
M anager
K . T a la m b e k o u

Personnel
The total number of persons working in the Production
Department, Quality Control Laboratory, Quality
Assurance and Packaging Department is 47.
9 persons comprise the scientific team.
1 Pharmacist - Plant Director
1 Chemist - Technical Director
3 Chemist - Production
2 Chemists - Quality Control
1 Chemist - Quality Assurance
1 Chemist - R & D
1 Biologist - Microbiological Laboratory
1 Engineer - Maintenance

Personnel
Quality Control = 6 persons
Quality Assurance = 4 persons
Production = 48 persons
R & D = 2 persons
Maintenance = 5 persons
Administration = 6 persons

Regulatory affairs
Applications and follow up of stages for the
registration of new products in the domestic
and overseas markets.
Continuous appraisal of information about
the law, regulations and patent requirements
applicable in different countries.
Traveling to meet with Agents and contact
Health Authorities abroad.

Promotion & Distribution

26 sales reps promote ANFARMs products all
over the Hellenic territory.
Special seminars and training programs are
followed by our sales staff.
Our exclusive representatives abroad maintain
their own sales network.
ANFARMs products are distributed from the
companys central warehouse in Athens.

Hellenic Market

ANFARMs exports

Exports %
100
90
80
70
60
50
40
30
20
10
0

Exports
Domestic

1998

1999

2000

2001

2002

2003

ACS DOBFARs project

Manufacturing Products
Carefully selected products for the
treatment of serious health problems,
merchandised under the companys name.
Products manufactured for third parties.

Contract manufacturing
agreements (GR)
Minerva - Faran - Kleva - Bros
Viostam - Adelco - Relyo - IFET
Finixfarm - Vocate - Medinova
Leovan - Coper - Remedina - Coup
Rafarm - Proel - Antor

Contract manufacturing
agreements internationally
Medochemie Cyprus, Curamed Germany,
Faulding Italy, DBL Australia, Farmauno Italy,
Merck Generics Italy, IPS Spain, Farmaplus Norway,
Dakota Sanofi Synthelabo France, Generis Spain,
Vita Spain, Caber Italy, Max Farma Italy,
Levo Farma Italy, Mayne Pharma Netherlsnds.

Pharmaceutical Forms

Solid forms (coated & uncoated tabs, capsules)

Semi-solid forms (ointments, creams, gels)
Oral Solutions, liquid syrups
Nasal sprays
Sterile liquids (small & large volume vials,
ampoules, lyophilized vials, eye drops)
Sterile solids
Chephalosporines (capsules, tablets, dry powder
injections, oral suspensions)

Product List
ANFARM offers a wide range of
products thus providing a solid base
for development both in the domestic
and overseas markets.

Pharmaceutical Categories
Anti-allergic: loratadine, sodium cromoglycate.
Anti-bacterial / Chemotherapeutics:
ciprofloxacine, norfloxacine.
Antibiotics: amikacin, doxycycline, amoxycilline,
ampicilline.
Anti-depressant / Anti-psycotic: sulpiride,
buspirone, fluoxetine.
Anti-diarrheal: nifuroxazide.

 Anti-fungal: bifonazole, fluconazole.

Anti-hypertensive: enalapril, lisinopril, captopril.
Anti-inflammatory / Analgesics: tenoxicam,
piroxicam, nimesulide, indomethacin,
etofenamate, nabumetone.
Anti-ulcer / Gastrokinetic: ranitidine, famotidine,
omeprazole, cisapride.
Anti-viral: aciclovir.
Ca antagonist: nimodipine.
Ca regulator: calcitonine.

 Cardiological: buflomedil, digoxin, dopamine.

Corticosteroids: dexamethasone / neomycin,
hydrocortisone, budesonide.
Espectoram: ambroxol.
Gynecological: clomiphen citrate.
Inhibitor platelet aggregation: ticlopidine.
Lipid regulator: simvastatine, gemfibrozil.
Tonic: L-carnitine.

Cephalosporins

Cefatrizine
Cefixime
Cefotaxime
Ceftriaxone
Cefuroxime
Cefuroxime axetil
( Ceftazidime )

Lyophilization
Since 1993 we have been manufacturing
lyophilized products. Result of our
specialization plan.
Tenoxicam
Vecuronium bromide
Hydrocortisone
Omeprazole

Epilogue
ANFARM is utilizing and enjoying the
results of a successful five-year business
development plan. The Company is set on its
aim to become one of the leading Hellenic
manufacturing Companies, serving both the
domestic and international markets.

./.