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  • Hemophilia: Bleeding Disorder Caused by Factor Deficiency

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    Hemophilia is a hereditary bleeding disorder characterized by a deficiency of coagulation factors VIII, IX, or XI. It can cause bleeding from the gums, nose, lips, and joints. The most common types are Hemophilia A, caused by factor VIII deficiency, and Hemophilia B, caused by factor IX deficiency. Diagnosis involves blood tests showing prolonged clotting times and treatment consists of replacement therapy with coagulation factors or supportive management of bleeding.

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    childhood disorders

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    Hemophilia

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    Hemophilia is a hereditary bleeding disorder characterized by a deficiency of coagulation factors VIII, IX, or XI. It can cause bleeding from the gums, nose, lips, and joints. The most common types are Hemophilia A, caused by factor VIII deficiency, and Hemophilia B, caused by factor IX deficiency. Diagnosis involves blood tests showing prolonged clotting times and treatment consists of replacement therapy with coagulation factors or supportive management of bleeding.

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    43 views5 pages

    Hemophilia: Bleeding Disorder Caused by Factor Deficiency

    Uploaded by

    Anonymous 0C4OZmR
    Hemophilia is a hereditary bleeding disorder characterized by a deficiency of coagulation factors VIII, IX, or XI. It can cause bleeding from the gums, nose, lips, and joints. The most common types are Hemophilia A, caused by factor VIII deficiency, and Hemophilia B, caused by factor IX deficiency. Diagnosis involves blood tests showing prolonged clotting times and treatment consists of replacement therapy with coagulation factors or supportive management of bleeding.

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    © All Rights Reserved
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    of 5

    HEMOPHILIA

    DEFINITION

    It is a bleeding disorder characterized by


    deficiency of factor 8, 9 and 11.

    ETIOLOGY

    Hereditary

    CLASSIFICATON
    Hemophilia A Classical hemophilia , occur
    due to deficiency of plasma factor 8. found
    in 80-85%.
    Hemophilia B- Christmas disease, result
    from deficiency of plasma factor 9. found in
    15-20%.
    Hemophilia C-result from deficiency of
    factor 11,found in few cases

    CLINICAL FEATURE
    Bleeding from gum nose lip and joints.
    GI bleeding(malena)
    Intracranial haemorrhage
    Hematuria

    DIAGNOSIS
    Blood test-CT, PTT is prolonged
    X-ray of affected joint
    Gene analysis for antenatal diagnosis

    MANGEMENT
    Replacement therapy
    Fresh whole blood transfussion
    Antifibrinolytics agent aminocaproic acid
    and tranexamic acid
    Supportive management
    Synovectomy
    Gene therapy
    Genetic counselling

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