Professional Documents
Culture Documents
SYNTHESIS
PROTEIN SYNTHESIS
DNA: NUCLEIC
ACID, DOUBLE
STRAND, PO4, DEOXYRIBOSE SUGAR.
BASE PAIRS (N)
T=THYMINE
A=ADENINE
C= CYTOSINE
G=GUANINE
RNA: NUCLEIC
ACID, SINGLE
STRAND, PO4,
RIBOSE SUGAR.
BASE PAIRS (N)
U = URACIL
A=ADENINE
C=CYTOSINE
G=GUANINE
URACIL (U)
base with a single-ring structure
phosphate
group
sugar (ribose)
POINTS ABOUT
TRANSCRIPTION
PROTEIN TRANSCRIPTION
NUCLEUS
RNA POLYMERASE CODES TO DNA
DNA TRANSCRIBES TO m-RNA
INTRONS SNIPPED OUT
EXONS KEPT IN CODE
exon
exon
cap
5
3
(snipped out)
(snipped out)
sugar-phosphate
backbone of
the other strand
of nucleotides
part of the
sequence of
base pairs in DNA
transcribed DNA
winds up again
DNA to be
transcribed
unwinds
Newly forming
RNA transcript
The DNA
template at the
assembly site
5
RNA polymerase
direction of transcription
PROTEIN TRANSLATION
m-RNA GOES
THRU RIBOSOME.
RIBOSOME IS rRNA,CODE
THREADS THRU
RIBOSOME.
AREA OF
RIBOSOME BOUND
TO tRNA
20 TYPES OF AA
ANTICODON ON
ONE END OF tRNA.
AA ON OTHER END
OF t-RNA
AA ATTACH TO
EACH OTHER IN
PEPTIDE BOND
FORM PROTEINS
P
(first
binding
site for
tRNA)
A
(second
binding
site for
tRNA)
TRANSCRIPTION
Pre mRNA
Transcript
Processing
mRNA
rRNA
tRNA
protein
subunits
Mature mRNA
transcripts
TRANSLATION
ribosomal
subunits
mature
tRNA
Convergence
of RNAs
Cytoplasmic
pools of
amino acids,
tRNAs, and
ribosomal
subunits
Synthesis of a
polypetide chain at
binding sites for
mRNA and tRNA
on the surface of
an intact ribosome
FINAL PROTEIN
Destined for use in
cell or for transport
VALINE
PROLINE
THREONINE
LEUCINE
GLUTAMATE
HISTIDINE
GLUTAMATE
GLUTAMATE
VALINE
PROLINE
LEUCINE
HISTIDINE
THREONINE
VALINE
ARGININE
GLYCINE
TYROSINE
ARGININE
GLYCINE
LEUCINE
TRYPTOPHAN
LEUCINE
ASPARAGINE
GLUTAMATE
TRANSCRIPTION AND
TRANSLATION
C DNA.
m-RNA.
t-RNA.
AMINO ACID
ATC-GCG-TAT
UAG-CGC-AUA
AUC-GCG-UAU
ISO-ALA-TYR
PEPTIDE BONDS/POLYPEPTIDES/PROTEINS
Translation
Nuclear
membrane
DNA
Transcription
Eukaryotic
Cell
Pre-mRNA
RNA Processing
mRNA
Ribosome
Translation
Protein
Translation
Types of RNA
A. Messenger RNA
(mRNA)
A U G G G C U C C A U C G G C G C A U A A
codon 1
protein methionine
codon 2
codon 3
glycine
serine
codon 4
isoleucine
codon 5
codon 6
glycine
alanine
codon 7
stop
codon
aa2
aa3
peptide bonds
aa4
aa5
aa6
anticodon
codon in mRNA
anticodon
tRNA MOLECULE
amino
acid
amino acid
attachment site
OH
methionine
U A
anticodon
amino acid
C. Ribosomal RNA
(rRNA)
Ribosomes
Ribosomes
Origin
Cytosol
(eukaryotic
ribosome)
Chloroplasts
(prokaryotic
ribosome)
Complete Ribosomal
ribosome subunit
80 S
40 S
60 S
rRNA
components
18 S
5S
Proteins
C.30
C.50
5.8 S
70 S
Mitochondrion 78 S
(prokaryotic
ribosome)
30 S
25 S
16 S
C. 24
50 S
4.5 S
C. 35
5 S
30 S
23 S
18 S
C. 33
50 S
5S
C. 35
26 S
Ribosomes
Large
subunit
P
Site
A
Site
mRNA
A U G
Small subunit
C U A C U U C G
Translation
Three parts:
1. initiation: start codon (AUG)
2. elongation:
3. termination: stop codon (UAG)
Translation
Large
subunit
P
Site
A
Site
mRNA
A U G
Small subunit
C U A C U U C G
Translation
Initiation
ASK - 2009
33
Translation
ASK - 2009
34
Translation
ASK - 2009
35
Translation
ASK - 2009
36
Initiation
aa1
1-tRNA
anticodon
hydrogen
bonds
U A C
A U G
codon
aa2
2-tRNA
G A U
C U A C U U C G A
mRNA
Translation
Elongation
09/29/16
ASK - 2009
38
Translation
Elongation
09/29/16
ASK - 2009
39
Translation
Elongation
Translation
Elongation
ASK - 2009
41
Elongation
peptide bond
aa3
aa1
aa2
3-tRNA
1-tRNA
anticodon
hydrogen
bonds
U A C
A U G
codon
2-tRNA
G A A
G A U
C U A C U U C G A
mRNA
aa1
peptide bond
aa3
aa2
1-tRNA
3-tRNA
U A C
(leaves)
2-tRNA
A U G
G A A
G A U
C U A C U U C G A
mRNA
aa1
peptide bonds
aa2
aa4
aa3
4-tRNA
2-tRNA
A U G
3-tRNA
G C U
G A U G A A
C U A C U U C G A A C U
mRNA
aa1
peptide bonds
aa4
aa2
aa3
2-tRNA
4-tRNA
G A U
(leaves)
3-tRNA
A U G
G C U
G A A
C U A C U U C G A A C U
mRNA
aa1
peptide bonds
aa5
aa2
aa3
aa4
5-tRNA
U G A
3-tRNA
4-tRNA
G A A G C U
G C U A C U U C G A A C U
mRNA
peptide bonds
aa1
aa5
aa2
aa3
aa4
5-tRNA
U G A
3-tRNA
G A A
4-tRNA
G C U
G C U A C U U C G A A C U
mRNA
aa4
aa5
Termination
aa199
aa3 primary
structure
aa2 of a protein
aa200
aa1
200-tRNA
A C U
mRNA
terminator
or stop
codon
C A U G U U U A G
Translation
Release
Translation
The difference
End Product
aa199
aa1
aa200
Polyribosome
incoming
large
subunit
1
incoming
small subunit
polypeptide
mRNA
TYPES OF PROTEINS
ENZYMES/HELICASE
CARRIER/HEMOGLOBIN
IMMUNOGLOBULIN/ANTIBODIES
HORMONES/STEROIDS
STRUCTURAL/MUSCLE
IONIC/K+,Na+
all regulate things put together critter
Protein Sorting
Mitochondria
Plastids
Peroxisomes
Vacuole
original
base triplet
in a DNA
strand
a base
substitution
within the
triplet (red)
As DNA is replicated, proofreading
enzymes detect the mistake and
make a substitution for it:
POSSIBLE OUTCOMES:
OR
One DNA molecule
carries the original,
unmutated sequence
GLUTAMATE
PROLINE
VALINE
HISTIDINE
LEUCINE
THREONINE
VALINE