Professional Documents
Culture Documents
Chapter 23
Functions
Gas exchange
Moving air
Protection
Communication (sounds)
Olfaction (smell)
Respiratory
Anatomy
Nose/Nasal Cavity
Pharynx
Shared structure
Larynx/Glottis
Epiglottis blocks
food entry
Trachea
Bronchi
Bronchioles
Alveoli (not shown)
Nose to
bronchioles
Respiratory
portion
Site of respiration
Exchanging CO2
and O2
bronchioles and
alveoli
Open system:
Trace the Flow of Air
Larynx/Glottis/Epiglottis
Glottis
opening
connecting
pharynx to
larynx
Epiglottis
Covers glottis
Prevents food
from entering
air ways
Bronchial Tree/Alveoli
More conducting airways
Trachea divides
R and L bronchi
Bronchi divide and branch to
Bronchioles
Bronchiole = little Bronchi
Alveoli
Tiny air sacs
Site of respiration (gas exchange)
Collectively make up respiratory
membrane in (150 million/lung)
Respiratory Defense
System
Nasal filtration
Respiratory
Defense System
Respiratory filtration
mechanisms
Mucus
Escalator
Respiratory
mucosa lines
conducting
portion
Cells produce
mucus to catch
particles
Cilia (hairs) sweep
Respiratory
Defense System
Respiratory filtration
mechanisms
Alveolar
Defense
Alveolar
Macrophag
es
Aka Dust
cells
Eat dust
Alveoli
Diffusion
distance is
small!
1 capillary bed
wraps each
alveolus
Gasses move
across
respiratory
membrane (2
cells thick) to
enter blood
O2
alveoli
blood
Respiratory
surfaces are
thin and moist
Surfactant
prevents
sticking
Surfactant
Detergent
breaks surface
tension of water
Allows alveoli to
inflate
Produced by
Pneumocyte II
Pleural
cavity
Cardiac
notch
Diaphragm
Poutside Pinside
Lung Mechanics
More V, Less P; Air Flows In
Lung Mechanics
Less V, More P; Air Flows Out
Exhalation. When the rib cage
returns to its original position
and the diaphragm relaxes, the
volume of the thoracic cavity
decreases. Pressure rises, and
air moves out of the lungs.
Pneumothorax
Collapsed Lung
Hole in parietal
pleura allows pleural
cavity to fill with air
No longer potential
space, but an actual
space
Air flows in
Lung recoils
(collapses)
Alveoli cant open
Pressure in pleural
cavity is too great
Involuntary control
Regulated by ANS and respiratory control center in
medulla oblongata
Chemoreceptors in arteries monitor CO 2 , O2 and H+
concentrations
High CO2 and H+ trigger reflex to increase breathing
Why CO2 and H+ ?
Carbonic acid
reaction occurs
in RBC
H2CO3 HCO3- + H+
Bicarbonate can diffuse into blood and H + binds Hb
Note:
Equation precedes to
equilibrium
If CO2 increases in
blood what happens to
pH?
If H+ concentration
increases what
happens to CO2 ?
PCO2
4045
mm Hg
If PCO2 rises
H2O CO2
H2CO3
H HCO3
PC
If PCO2 falls
H HCO3
Hypercapnia
Acidosis
Hypocapnia
Alkalosis
H2CO3
H2O CO2
pH
O2
pH
7.357.45
HOMEOSTASIS
P CO 2
Medulla
oblongata
Chemoreceptors and
of carotid
and aortic sinuses
Diaphragm
Spinal
cord
Motor neurons
controlling
diaphragm
Motor neurons
controlling other
respiratory muscles
KEY
Phrenic nerve
Stimulation
Inhibition
Increased
arterial PCO2
A rise in arterial
PCO2 stimulates
Stimulation
of arterial
chemoreceptors
Stimulation of
respiratory muscles
Increased PCO2 ,
Stimulation of CSF
chemoreceptors at
medulla oblongata
decreased pH
in CSF
Increased respiratory
rate with increased
HOMEOSTASIS
DISTURBED
chemoreceptors that
accelerate breathing
cycles at the inspiratory
center. This change
increases the respiratory
rate, encourages CO2 loss
elimination of CO2 at
alveoli
Increased
arterial PCO2
(hypocapnia)
(hypercapni
a)
Normal
arterial PCO2 2
A drop in arterial
PCO2 inhibits these
Start
Normal
arterial PCO2
HOMEOSTASIS
DISTURBED
chemoreceptors. In the
absence of stimulation
the rate of respiration
decreases, slowing the
Decreased respiratory
rate with decreased
Decreased
arterial PCO2
elimination of CO2 at
alveoli
(hypocapnia)
HOMEOSTASIS
RESTORED
HOMEOSTASIS
Decreased
arterial PCO2
Decreased PCO2 ,
increased pH
in CSF
Inhibition of arterial
chemoreceptors
Reduced stimulation
of CSF chemoreceptors
Inhibition of
respiratory muscles
Alveolus
PO2 = 40
PCO 2 = 45
Systemic
circuit
Pulmonary
circuit
Respiratory
membrane
PO 2 = 100
PCO 2 = 40
O2
CO 2
Pulmonary
capillary
PO 2 = 100
PCO 2 = 40
Internal Respiration
Interstitial fluid
Systemic
circuit
PO2 = 95
PCO2 = 40
PO2 = 40
PCO2 = 45
CO
2
PO2 = 40
PCO2 = 45
Systemic
capillary