A researcher is studying specific immune responses to

antigens by incubating it with several different cell

types. He notices that just the antigen alone will cause
activation of B cells, but not T cells. However, when the
T cells are incubated with antigen presenting cells in the
presence of the antigen, they become activated. What
type of antigen is the researcher using in his study?

a. A whole protein in native conformation

b. A whole protein that has been de natured
c. A whole protein cut into tetramer peptides
d. A whole protein cut into pentamer peptides
e. Polysaccharide
f. Lipids
g. Hapten

A large protein has been enzymatically digested in the

laboratory to yield a mixture of peptides ranging in size from
four to six amino acids which of the following would be expected
if the peptide mixture were administered to an experimental
animal together with an adjuvant?
a. Peptide specific antibodies would be generated using the
peptide mixture alone
b. Peptide specific antibodies would be generated only if
adjuvant were administered with the peptide mixture
c. Peptide specific antibodies would be generated if they were
coupled with a protein carrier
d. Peptide specific antibodies and T cell responses would be
generated using the peptide mixture alone
e. There would be neither a humoral immune response nor a cell
mediated immune response to the peptides in the mixture

1.Antibodies to Treponema pallidum,

bacteria which causes syphilis cross
reacts with cardiolipin, which is found
in beef heart muscle. What is this a
good example of?
a.Heterophile antigens
b. Homologous antigens
c. Syngenic antigens
d. Allogenic antigens

4.In the process of vaccine development, a

researcher injects a purified polysaccharide into a
mouse and evaluates the immune response. Despite
repeated inoculations (boosters) over a couple of
weeks, he notes that each time, the mouse takes the
same amount of time to mount the same type and
level antibody response. What could be the most
likely explanation for the observation?
a. It is a T independent antigen
b. It is a hapten
c. It is not antigenic
d. It is a T dependent antigen
e. It is not immunogenic

A childs tissue type is HLA-A2,23; HLAB5,13;HLA-C4,7

The mothers type is HLA-A4,23;HLAB5,17;HLA-C2,7
which of the following is fathers
a. HLA-A4,23;
b. HLA-A2,13;
c. HLA-A6,23;
d. HLA-A2,13;

HLA-B5,13;HLA-C2,7
HLA-B13,27;HLA-C4,14
HLA-B5,12;HLA-C4,6
HLA-B5,12;HLA-C2,7

6. In virus infected cells, the virus

antigen is most likely to displayed in
which of the following ways?
a. On
b. On
c. On
d. On
e. On

an molecule
an 2 macroglobulin molecules
HLA DP,DQ, DR gene product
MHC class II
MHC class III

7.Which of the following determines how a

microbial antigen would be displayed to
the T cells?
a. The nature of the microbe, virus,
bacteria, fungi, parasite
b. Intracellular pathogen
c. Extracellular pathogen
d. Location and Route of antigen digestion,
cytosolic versus endosomal
e. Whether it is administered with adjuvant

Mathew is a first year medical student,

and is required to take his vaccine
shots and demonstrate protective
titres. He was surprised to note that
despite completing the vaccine
schedule, he was not responding to a
particular vaccine at all. What could be
a reasonable explanation for him not
responding to a particular vaccine?

Extracellul Endosom
ar protein e w/
acidic pH
18-20
aa
cli
p

ER: MHC I,
II are
being
synthesize
d

CD4 TH
cell

1)
Infection

2)
Phagocytosi
s
Escape into
cytosol