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Lineages
Blood and
lymphocyte lineages.
The final stage of differentiation is the erythrocyte, or mature red blood cell. Here, no
division, RNA synthesis, or protein synthesis takes place. The DNA of the erythrocyte
condenses and makes no further messages.
Amphibians, fish, and birds retain the functionless nucleus; mammals extrude it from
the cell. The cell leaves the bone marrow and delivers oxygen to the body tissues.
Similarly, there are lineage-restricted stem cells that give rise to platelets, to
Hematopoietic growth
factors
Some hematopoietic growth factors:
IL-3 stimulate the division and maturation of the early stem cells,
thus increasing the numbers of all blood cell types.
Erythropoietin are specific for certain cell lineages only.