Professional Documents
Culture Documents
Siregar, FAAFM, FAARM, FAABM, DIHom, DNMed, MSc, MA, ND, PhD
Konsultan
Naturopati, Anti Aging, Wellness & Functional Med
he Role of Phytomedicin
for
Anti Aging Intervention
Amarullah H. Siregar
GLOBAL TRADE
17 February 2010
Chronological age
Biological age
The performance of an individuals
body
system from mental
function to sexual performance to
physical strength
Relationship between chronological
age and programmed cell death
(apoptosis) which seems to be an
essential part of the life of
Air Pollution
Processed
AirFoods
Pollution
Food additives/
Chemicals
Pesticide/
Herbicide
External Toxins
Stress
Tobacco
smoke
Excess food
intake
Drinking
water
XENO-BIOTIC
DEGENERATIVE PROCESS
Hormonal
Skin
Immune
Psychological
Obesity
Organ damage
PREMATURE AGING
MEDICINE TODAY
CONVENTIONAL
NON CONVENTI
Naturopath
Anti Aging M
Wellness M
Functional M
Restorative
Ultimate achievements of
biological age and practical
immortality , which we live
vital life spans
Find solutions to eliminate or
at least to alleviate the
Population in millions
120
55-64
90-
65-74
75-84
85+
60-
30-
1900
1930
1960
1990
2020
2050
naturoceutical
Signal transduction
Receptors
Y
Transporter
Ion
channels
YY
Electron transport
DNA
- Replication
- Transcription
- DNA repair
Protein
biosynthesis
Mitochondrion
n
u
c
l
e
u
s
Enzymes
RNA
lysosome
Cell membrane
Cytoskeleton
(actin, microtubules)
Posttranslational
protein modification
AGING PATHWAY
BIOMOLECULAR
AGING
IGF secretion
Biological clock
PHYTOMEDICINE AGING
Phytomedi
cine
Interacting proteins
Parathymosine
Activator NAD
SIRT1 expression
Sirtuin homolog 1
PGC1
Peroxisome coactivator1
Gluconeogenesis
Fatty acid oxidation
FOXO1
SIRT1
Forkhead box 01
Gluconeogenesis
Insulin secretion
Adiponectin production
Insulin secretion
Insulin sensitivity
CRTC2
Creb Regulated
Transcription Coactivator2
GluconeogenesisB
STAT3
LXRs
Liver X receptor
Lipid metabolism
NfkB
AceCS1
Gluconeogenesis
Acetyl CoA synthetase
Acetyl CoA scavenger
Calorie
restriction
Natural
substances
ology and Medicine.. Volume 51, Issue 2, 15 July 2011, Pages 250256
Phytomedi
cine
DNA
repair
Carcinogen
metabolism
Hormonal
regulation
Bioactive
component
Cell
cycle
Differentiate
Apoptosis
tss
en
nt
enve ts
n
ro
lap eve
oum
t cll lar
an ce lu
pl fy cel
ive dfi y
ct oodi
m
oa
Bi n nm
caca
Metabolites
Proteins
mRNA
Genes
Metabolic pathways
Functional modules
od Cel
ify lul
re ar e
pl
an spon ven
tc
t
s
om e t o s c a
po
Bi n
n e oa
nt ct
i ve
s
Phenotype
Epigenomic
CH3-DNA
Nutrigenetic
Nutrigenomic
Post translational
DNA
mRNA
Proteins
Bioactive
Food
Components
Enzyme, Structural
Transport, Signaling
caused by
Phosphorylation and
Glycocylation
PHYTOGENOMIC APPROACHES
GENOMIC
METABOLOMIC
PROTEONOMIC
BIO-INFORMATIC
Biomolecular
Bioactive plant component
BIO-ACTIVATION
DNA repair
Cell communication
Cell signaling
GENETIC STABILITY
BIOLOGICAL PROCESS
Van Ommen et al 2002. Curr Opin Biotech; 13 : 517-521
Natural substances
Nutrients
Phytochemicals
Source of
energy
Growth and
Tissues
maintenance
Regulation
Body Process
Body
Organ &
Composition System function
Phytonutrient
Phytochemical
Phytoenzyme
Phytohormone
Phyto-allel
Human cells & genes
Gene
Gene
Gene
Gene
Gene
transcription
modulation
regulation
translation
expression
Recuperation
Rejuvenation
Revitalization
Miller G, 1997 J of Am Col Nutr;16: 293-295
1. Zeroing in on molecular
targets
2. Reducing oxidative stress
3. Decreasing DNA damage
4. Inhibit mitochondrial
disturbance
5. Enhancing DNA repair
6. Improve immune functions
7. Blocking inflammation process
8. Optimizing gene expression
9. Improve molecular function
10. Nourish your genes
Cancer Letters
Volume 267, Issue 1, 18 August 2008, Pages 133164
See nutrigenomic