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Cardiovascular Research
Over the past several years, many changes took place in the treatment of
cardiovascular (CV) disease, which resulted in marked decline in rates of
morbidity and mortality.
In this article we write about 5 emerging trends within drug research sector
are highlighted each reinforces the need for therapeutically centric,
methodologically strenuous, and highly efficient project teams for product
assessment and commercialization. These trends are:
Drugs treating metabolic faults like dyslipidemias and type 2 diabetes mellitus
are on the current scenario of treatments which defined multiple effects
assumed under the concept of pleiotropy. The impact of type II diabetic
therapy on the CV system prompts concern and look after. The most recent
target is the enzyme dipeptidyl peptidase 4 (DPP-4).
This would support the notion that the cardiovascular effects, whether positive
or negative, might not be a class-specific phenomenon of DPP-4 inhibitors.
Further research to understand the CV effects of this diabetic drug based on
primary as well as secondary targets would lead to major progress that could
influence the management of the CV disease.
2) Personalized Treatment
Precision medicine like one-dose gene therapy treatments are also making
developments. Here, a vector is designed to introduce genetic material into cells to compensate for
unnatural genes or to yield a beneficial protein. The application has been recently introduced for
cardiac arrest patients have great implication for trial design and commercial purposes.
3) Epigenetics and MiRNA Antisense Oligonucleotide
Therapeutics
For instance, methylation status for certain genes has been found linked with
increased risk of CV disease in discrete populations, like F2RL3 in smokers,
PLA2G7 in females, and locus 9p21 within the Chinese people. Promising
antisense oligonucleotide technologies says that oligonucleotides themselves
might soon emerge in the therapeutic field.
4) Innovative Trial Methods
Basic research, drug discovery and drug development are too often viewed as
being at different ends of a research and development process. But the fact is
that they are complementary and enmeshed. CRO serves as a mediator of the
process should exemplify an ability to manage, facilitate, and support the
interests of various stakeholders and thus transforms the way clinical research
can be conducted.
We conclude the discussion here. Stay connected with us this space for more
discussions.
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