Mitochondrial DNA haplogroups influence the risk

of incident knee osteoarthritis in OAI and CHECK

cohorts. A meta-analysis and functional study
Mercedes Fernndez-Moreno,1 Angel Soto-Hermida,1 Mara E Vzquez-Mosquera,1 Estefana Corts-Pereira,1 Sara Relao,2
Tamara Hermida-Gmez,1 Sonia Prtega,3 Natividad Oreiro-Villar,1 Carlos Fernndez-Lpez,1 Rafael Garesse,4,5 Francisco J
Blanco,1 Ignacio Rego-Prez1

Diciembre 5 del 2016

British medical journal (BMJ)

F.I. 12.38
Objetivo
To evaluate the influence of the mitochondrial DNA
(mtDNA) haplogroups in the risk of incident knee
osteoarthritis (OA) and to explain the functional
consequences of this association to identify potential
diagnostic biomarkers and therapeutic targets.
Hipotesis
The haplogroup H and J decrease incidents of knee
caused by OA
Metodos
Cybrid cultures and culture conditions
Flux assay measurements
Mitochondrial reactive oxygen species production assay
Oxidative stress response assay: viability assay
Apoptosis assay
Statistical analysis
Figuras
Conclusin
The physiological effects of the haplogroup J are
beneficial to have a lower rate of incident knee OA over
time. Potential drugs to treat OA could focus on
emulating the mitochondrial behaviour of this
haplogroup.