JOURNAL READING

CRISTALLOID FLUD
TERAPHY

Pembimbing
Dr. Dian Ayu, Sp.An
Disusun oleh:
Dian Fofana Diarra
Fitri Ayu Nurani
PENDAHULUAN

To find solution that rejuvenate and resucitate

Intravenous fluids are an integral component of the
multimodal resuscitation strategy used in medicine.
The majority of intravenous fluids were introduced into
clinical practice during an era where they did not
undergo the same scrutiny as other drugs
Hence, there is a paucity of research in this area and
only recently has there been an increase in academic
interest in the comparative effectiveness of different
intravenous fluids.
Tujuan

Evidence base dalam pemilihan cairan

resusitasi (Studi pada hewan)

Membandingkan cairan kristaloid dan

memberikan saran untuk penelitian
selanjutnya

Membandingkan keefektifan berbagai

macam airan kristaloid
METODE PENELITIAN

Desain penelitian dan populasi

Jenis
Deskriptif
Populasi
Semua penilitan yang menggunakan terapi kristaloid
Sampel
1.232 pasien diabetes yang menyajikan ulkus kaki baru untuk
pertama kalinya
 Kriteria inklusi
Penelitian yang menggunakan kristalloid
Penelitian yang berjenis interventional
comparative effect between buffered and
unbuffered crystalloid, dan atau RCT : Animal
studies, Observational studies, Interventional
studies comparing 0.9 % saline to buffered
crystalloid fluids, The SPLIT program.
Kriteria eksklusi
Bukan merupakan penelitan interventional
dan atau RCT
Definisi Operasional

KRISTALOID
Unbuffered/unbalance crystalloid
The composition of 0.9 % saline and is not physiologically
normal. First, 0.9 % saline has a higher chloride
concentration than plasma. Second, 0.9 % saline has a
different strong ion difference (SID) to plasma
Following an infusion of 0.9 % saline there is a net decrease
in the plasma SID resulting in a metabolic acidosis.
as a relatively hypertonic solution because the sum of its
osmotically active components. And is more accurately
referred to as an isotonic solution as its constituents
sodium and chloride are only partially active
Definisi Operasional

KRISTALOID
Buffered/ balanced crystalloid
Ringer solution : ringer lactat, ringer acetat
Hartmanns solution
Unlike 0.9 % saline, the available buffered crystalloid
solutions contain physiological or near physiological amounts
of chloride. One of the key differences between 0.9 % saline
and buffered/balanced crystalloids is the presence of
additional anions, such as lactate, acetate, malate and
gluconate, which act as physiological buffers to generate
bicarbonate.
Hasil
CONCLUSION

Intravenous fluid therapy is a ubiquitous intervention in

critically ill patients. While preclinical and observational
data raise the possibility that the choice of crystalloid
fluid therapy may affect patientcentered outcomes,
0.9 % saline and PlasmaLyte 148 result in similar
rates of renal complications when used for fluid therapy
in patients undergoing major surgery and in ICU
patients.
CRITICAL APPRAISAL
 PICO

Patient Intervention Comparison Outcome

Patient dengan Crystalloid Unbuffered/ Tingkat

instability buffered keseimbangan
hemodinamic hemodinamik
pasien.
 Identitas Jurnal
Judul
Crystalloid fluid teraphy
Author
Sumeet Reddy1*, Laurence Weinberg2,3 and Paul Young1,4.
Publisher
Bio. Med. DOI 10.1186/s13054-016-1217-5
Tahun
2016
 Judul
Hanya menyebutkan tentang crystalloid fluid teraphy, tidak
menjelaskan jenis maupun variebel-veriabel yang diteliti dalam
judul.
Ditulis dalam cetak tebal
Tanpa singkatan
Tidak lebih dari 12 kata
Tidak terdapat tempat dan waktu penelitian pada judul
 Abstract

Mencakup objek, metode, hasil, & kesimpulan, kata kunci

Informatif,
Lebih dari 250 kata (277)
 Pendahuluan
Terdiri dari 2 bagian atau paragraf
Alasan dilakukan penelitian
Penelitian sebelumnya
Tujuan penelitian (+) hipotesis penelitian (-)
Kurang dari 1 halaman
 Metode
Populasi dan sampel berikut kriteria sampel dijelaskan
Mendapat persetujuan dari komite etik penelitian
Definisi operasional variabel jelas
Alat statistik
Desain dan detail penelitian dijelaskan dalam penelitian
sebelumnya
Data berasal dari pusat di kawasan yang berbeda
 Hasil
Disajikan dalam tabel dengan penjelasannya
Penulisan tabel dengan nomor urut dan judul
Penyajian tabel mengikuti aturan penulisan jurnal internasional (tanpa
garis vertikal dan horisontal dalam)
Nilai p hasil uji statistik disertakan
Terdapat tabel karakteristik subjek
Diskusi
Ada perbandingan dengan hasil dan penelitian-penelitian terdahulu
Disebutkan keterbatasan penelitian